OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 15.0 days from acceptance to publication (median values for papers published in this journal in the second half of 2021, 1-2 days of FREE language polishing time is also included in this period).
Submission Deadline: March 31, 2021 (Open) Submit Now
Jean-Baptiste Vannier, PhD
Telomere Replication and Stability Group Head, MRC London Institute of Medical Sciences (LMS), London, United Kingdom
Honorary Senior Lecturer, Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
Research Interests: Cell Biology; Cancer Research; Molecular Biology; Genome Stability; Telomere; DNA Replication; DNA Damage Response; Homologous Recombination; Cell Culture; Chromosome Breakage; Recombination.
Rosa Maria Porreca, PhD
Research Scientist, Telomere Replication and Stability Group, MRC London Institute of Medical Sciences (LMS), London, United Kingdom
Faculty of Medicine, Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
Research Interests: Telomere; DNA Replication; Cell Biology; Chromosome Breakage; Recombination.
About This Topic
Eukaryotic chromatin is a highly organized DNA-protein complex tightly packaged into a compact structure inside the nucleus. The basic unit of this structure is called nucleosome and consists of a histone octamer (H2A, H2B, H3, H4) wrapped around by 147 bp of DNA and a histone linker H1. Chromatin a is very dynamic structure and a wide variety of protein complexes are involved in different mechanisms to remodel chromatin by altering position, occupancy or composition of a nucleosome. Given the tightly compacted genome, chromatin remodeling can switch on and off DNA accessibility as needed, therefore regulating several biological processes like transcription, DNA replication, repair and recombination, chromosome assembly, cell-cycle and segregation, embryonic development and other processes. Hence, any defects in chromatin remodelers can lead to a broad spectrum of diseases including developmental disorders and cancer.
In this special issue we invite you to submit the latest research progress, innovative methodologies or therapeutics interventions, in all areas pertinent to the chromatin remodeling topic. Original research papers, reviews, editorial, short communications, case reports and perspectives are all welcome for submission.
Received: 17 June 2021; Published: 17 November 2021; doi: 10.21926/obm.genet.2104143
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