The Role of Genetic Counseling in Gynecological Oncology
Abstract
Table of Contents
Open Access
ISSN 2577-5790
© 2019 by the authors; CC BY 4.0 licence
OBM Genetics , Volume 3 , Issue 4 (2019)
Pages: 143
Published: April 2020
(This book is a printed edition that was published in OBM Genetics)
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Cover Story: Cancer is probably caused by the very common chromosome mis-segregation at cell division. The organism has at least five mechanisms to prevent that mis-segregation damage develops into cancer. The mechanisms are tetraploidization, cell division arrest, apoptosis, elimination by the immune system, and prevention of division of macrophage/precancer cell fusions. View this paper.
Volume 3,Issue 4
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Combination of the Hansemann-Boveri, Warburg, and Knudson Theories of Cancer, Based on Failure of Missegregation Damage MitigationAbstract Hansemann-Boveri’s aneuploidy theory, the Warburg effect, and the Knudson hypothesis can be viewed as different aspects of a single theory of cancer. In this, the extremely common chromosome missegregation may be the underlying cause. Chromosome missegregation is mitigated via several mechanisms. Cancer can occur only when all of these mechanisms have been inactivated in a single cell line, typically by mutation. There are at least five different repair mechanisms, implying a hit-factor of at le [...] |
Nutrition, Cancer Genetics and EpigeneticsAbstract Epidemiological data and meta-analysis have confirmed that there exists a strong association between nutrition and disease risk. In the context of cancer, it has been demonstrated that unhealthy diets increase the risk of disease. On the other hand, major dietary interventions and lifestyle changes have been demonstrated to provide therapeutic efficacy in cancer patients. Genetic mechanisms have been reported to be associated with cancer development induced by environmental and nutritional facto [...] |
Diversity in the Bacterial Genus Dickeya Grouping Plant Pathogens and Waterways IsolatesAbstract |
Optimizing Phage Translation Initiationby
Xuhua Xia
Abstract Phage as an anti-bacterial agent must be efficient in killing bacteria, and consequently needs to replicate efficiently. Protein production is a limiting step in replication in almost all forms of life, including phages. Efficient protein production depends on the efficiency of translation initiation, elongation and termination, with translation initiation often being rate limiting. Initiation signals such as Shine-Dalgarno (SD) sequences and start codon are decoded by anti-SD sequences and init [...] |
Insulin-Like Growth Factor 2 in Physiology, Cancer, and Cancer Treatmentby
Bas T Röttgering
and
Karoly Szuhai
Abstract Insulin-like growth factor 2 (IGF2) is a strong mitogenic peptide with an imprinted gene that is primarily involved in fetal development. It is highly expressed in the fetus where it is involved in fetal growth and tissue differentiation. However, postnatally, the expression of IGF2 decreases despite higher expression levels in the blood as compared with that of IGF1. In adults, the physiological function of IGF2 is poorly understood; however, the possibility of a metabolic function exists. Alth [...] |