by Sabrine Mekni  , Lamia Torjemane  , Malek Khayati  , Dorra Belloumi  , Rimmel Yosra Kanoun  , Insaf Ben Yaiche  , Rihab Ouerghi  , Ines Turki  , Saloua Ladeb  , Tarek Ben Othman  and Nour Ben Abdeljelil

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...]

by Mumtarim Haque Mim  , Biswajit Das  , Sheikh Mahfuja Khatun  , Sadia Akter  , Jannatul Naim  , Mohammad Anowar Hossain  , Mohammad Pessarakli  and Mohammad Anwar Hossain

Received: 31 May 2025;  Published: 07 August 2025;  doi: 10.21926/obm.genet.2503306

Low phenotypic and genotypic variability for yield-attributing traits and susceptibility to salinity stress are constraints of mungbean productivity. The objectives of the study are to phenotype a set of exotic mungbean genotypes for yield-attributing traits and salinity tolerance, as well as to conduct genetic analysis of these traits for efficient selection. Three consecutive experiments were conducted to fulfill these objectives. In the first experiment, 26 mungbean genotypes were evaluated for yield traits unde [...]

by Abubakar Siddiq Salihu  , Wan Mohd Nuzul Hakimi Wan Salleh  , Nurunajah Ab Ghani  , Mohd Hafiz Arzmi  , Bunleu Sungthong  and Ravikumar Kapavarapu

Received: 05 March 2025;  Published: 27 April 2025;  doi: 10.21926/obm.neurobiol.2502286

The Myristicaceae family, particularly the Knema genus, is renowned for its diverse bioactive compounds, including lignans, flavonoids, and phenolics. This study explores the phytochemical profile of Knema hookeriana Warb. leaves and evaluates their potential as acetylcholinesterase (AChE) inhibitors. Phytochemical extraction was performed using a cold maceration method with a polarity-gradient solvent system (hexane, ethyl acetate, and methanol). The isolated compounds were purified through chromatographic techniq [...]

by Faten Dhawi  and Shefin Basheera

Received: 12 March 2025;  Published: 25 May 2025;  doi: 10.21926/obm.genet.2502295

Jatropha curcas L., a medicinal shrub renowned for its diverse phytochemicals, has been traditionally used to treat various ailments, including ulcers, neoplasms, and dermatological conditions. Despite its pharmacological promise, its potential against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) remains unexplored. This study investigates the antiviral efficacy of J. curcas phytochemicals targeting the SARS-CoV-2 main protease (Mpro), a critical enzyme for viral replication, using advanced computat [...]

by Jennifer Vasquez  , Michele Quill  and Chase Bossart

Received: 17 January 2025;  Published: 14 March 2025;  doi: 10.21926/obm.icm.2501014

In this qualitative study, the impact of therapeutic Viniyoga on health and healing was explored from the perspective of 14 Viniyoga therapists who were interviewed on their perceptions of how yoga therapy contributes to the health and healing of their clients. A philosophical definition of Therapeutic Viniyoga was developed. Three themes related to health and healing from the perspective of Viniyoga therapists were identified using NVivo and Interpretative Phenomenological Analysis procedures: The definition of he [...]

by Yasuhiro Kotera  , Noelia L. Martínez-Rives  , Muhammad Aledeh  , Habib Adam  , Julie Beaumont  , Rory Colman  , Jessica Eve Jackson  , Christian Veasey  , Lucie-May King  , Tracey Harrington  , Elaina Taylor  , Ann-Marie Edwards  , Gabby A. A. Rothwell-Blake  , Adewale Allen Sokan-Adeaga  , Gillian H.T. Liu  , Kenneth Curley  , Matthew Cotterill  , Malik Dimbei Halidu  , Juliet Wilkes  , Aiesha Carew Tofani  , Samantha Greaves  , Rob Hughes  , Annabel Rushforth  , Ann Kirkman  , Michelle Brooks-Ucheaga  and Kristian Barnes

Received: 14 February 2024;  Published: 22 August 2024;  doi: 10.21926/obm.icm.2403048

This short report presents an international research group, Research Ensemble for Advancement in Cross-cultural Healthcare (REACH). REACH is an independent research group, and no one is paid to do research for REACH. All members participate because they are intrinsically motivated to pursue cross-cultural healthcare. REACH consists of 28 healthcare workers and educators from 13 countries, researching about cross-cultural issues in healthcare (18 publications on average per year as of February 2024). REACH is multi- [...]

by Marcel Tomaszewski  and Philip Wong

Received: 22 August 2018;  Published: 03 January 2019;  doi: 10.21926/obm.hg.1901013

There is evidence to suggest that older livers regenerate less well and display cellular senescence. Additionally, elderly patients with certain liver diseases have a less favourable course. Chronic liver disease, amongst the elderly, has a significant negative effect upon quality of life and functional independence. Frailty, commonly encountered in geriatric patients, remains a significant negative predictor of physical, psychological, functional and survival outcomes in chronic liver disease. Despite advances in [...]

by Jose Benavides  , Pushpesh Sharma  , Ahmed Al Saedi  and Shah Kabir

Received: 20 November 2023;  Published: 21 February 2024;  doi: 10.21926/jept.2401007

This article outlines an innovative approach to explore thermal energy extraction for power generation or industrial hot water applications. Unlike traditional steady-state models, this approach embraces time-variant scenarios, explicitly incorporating a cyclical fluid circulation strategy to maintain a stable surface fluid temperature or power output. By introducing an increasing and decreasing stepwise rate sequence and an intermittent circulation strategy, the method aims to optimize efficiency in response to va [...]

by Aileen M. Lynch  , Gabrielle McKee  , Fintan Sheerin  , Jean-Luc Bosson  , Monique Epstein  , Ariane Girault  , Carole Rolland  , Mary Harkin  , Ciaran McKinney  and Pierre Gillois

Received: 05 June 2024;  Published: 17 December 2024;  doi: 10.21926/obm.geriatr.2404292

While the facilitators/barriers for the initiation of physical activity (PA) are well documented, there is less known about these facilitators/barriers for maintenance of PA in the older population in general and not following an intervention. This study aimed to explore older adults’ perspectives on the facilitators/barriers to maintaining PA. The study used descriptive qualitative design, with three focus groups, one in Ireland and two in France. Participants were community-dwelling older adults (≥60 years) 66% w [...]

by Amale Laouar

Received: 22 July 2018;  Published: 09 September 2018;  doi: 10.21926/obm.hg.1803010

Gut microbes and pathophysiology of sepsis: Spillage of gut microbial products, rather than systemic dissemination of gut microbes, is the potential initiator of septic morbidity

by Igor Val Danilov  , Dace Medne  and Sandra Mihailova

Received: 09 February 2025;  Published: 03 July 2025;  doi: 10.21926/obm.neurobiol.2503290

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field an [...]

by Jasmin Hundal  and Mariam AlHilli

Received: 19 August 2024;  Published: 19 March 2025;  doi: 10.21926/obm.geriatr.2501304

Elderly patients with ovarian and pancreatic cancer frequently experience malnutrition and sarcopenia, which negatively impact treatment tolerance, functional outcomes, and survival. The increasing use of neoadjuvant chemotherapy in this population necessitates structured interventions to mitigate these challenges. While prehabilitation has shown promise in enhancing treatment tolerance and quality of life, its role during chemotherapy remains underexplored. This prospective study evaluates the feasibility and impa [...]

by James David Adams

Received: 22 August 2023;  Published: 11 January 2024;  doi: 10.21926/obm.icm.2401009

Many websites are dedicated to educating the public about chronic pain and its management. The majority of these websites say there is no cure for chronic pain, but encourage patients to try exercise, diet, stress reduction and other techniques to decrease the severity of chronic pain. Patients are also taught to use oral or injected drugs to treat their chronic pain. This can be dangerous and leads to adverse events and death in some patients. The majority of these websites teach patients that chronic pain comes f [...]

by Tayseer A. S. Idrees  and Ibtisam E. M. El Zubeir

Received: 06 April 2024;  Published: 27 April 2025;  doi: 10.21926/rpn.2502009

This study was conducted to investigate the effect of sources. locations and seasons (late summer and winter) on the chemical composition of cow milk collected from Khartoum State. The samples were collected randomly in the morning or the evening. Two hundred and seventy milk samples were collected from farms (90 samples), groceries (90 samples) and vendors (90 samples) in Khartoum State during the late summer and winter seasons, 135 samples each. The milk samples were kept in cool cracked ice and transported immed [...]

by Recent Progress in Science and Engineering Editorial Office

Received: 22 June 2025;  Published: 23 June 2025;  doi: 10.21926/rpse.2502010

by Andrea Bellieni  , Beatrice Di Capua  , Emanuele Rocco Villani  , Luca Tagliaferri  , Domenico Fusco  , Maria Antonietta Gambacorta  , Francesco Presta  , Serena Bracci  , Vincenzo Valentini  , Francesco Landi  and Giuseppe Ferdinando Colloca

Received: 17 November 2022;  Published: 13 June 2023;  doi: 10.21926/obm.geriatr.2302238

New technologies, aging-related changes, and evolution in patients' needs have led to a new scenario in all oncological fields in front of which we have to move on. Technological progress has made it possible to increase the number of patients treated, including elderly patients and generally those at higher risk of toxicity. However, this scenario has led to new problems requiring new skills to be addressed. For this reason, Gemelli-ART (Advanced Radiation Therapy) of Fondazione Policlinico Universitario A. Gemell [...]

by Max G Blackwell  , Stephanie C Brown  and Andrew S Day

Received: 10 July 2024;  Published: 24 October 2024;  doi: 10.21926/rpn.2404017

We present a case report of an 11-year-old girl diagnosed with Crohn’s Disease and managed with maintenance cyclic exclusive enteral nutrition with satisfactory long-term biochemical and symptomatic control.

by Jennifer Vasquez  , Michele Quintin Quill  and Chase Bossart

Received: 30 May 2024;  Published: 23 September 2024;  doi: 10.21926/obm.icm.2403054

While many studies have discussed the effectiveness of interventions using different yoga techniques and teachings with various populations, there has been less research on the effectiveness of yoga therapy. Viniyoga therapists utilize the principles of Viniyoga, a type of yoga developed by Krishnamacharya, to provide therapeutic yogic interventions to individual clients in order to improve functioning and relieve suffering. This qualitative study conducted interviews with fourteen Viniyoga trained yoga therapists [...]

by Adam Resnick  , Alicia Bergman  , Rebecca Oberman  , Stephanie L. Taylor  , Emmeline Chuang  , Kelsey Cummings  and Evelyn T. Chang

Received: 20 December 2023;  Published: 31 January 2024;  doi: 10.21926/obm.icm.2401012

The Veterans Health Administration (VA) offers complementary and integrative health (CIH) therapies to Veterans with chronic pain and opioid use disorder (OUD). While CIH therapies have known benefits for chronic pain, less research exists on its use for patients with OUD. In this qualitative study, we aimed to assess provider and patient perceptions of CIH therapies for Veterans with OUD. We interviewed 45 providers involved in OUD care and 17 Veterans with OUD from five VA medical centers as part of a larger mixe [...]

by Nasrin Motazedian  , Masoud Mokhtari  , Negar Azarpira  , Kimia Falamarzi  , Mohsen Mohammadi  , Seyed Mohsen Dehghani  , Sarina Pourjafar  , Maryam Ataollahi  , Elaheh Esfandiari  , Mahdokht Hossein-Aghdaie  , Seyed Ali Malekhosseini  , Tayebeh Kazemi  and Mahintaj Dara

Received: 05 May 2024;  Published: 04 June 2024;  doi: 10.21926/obm.transplant.2402217

Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) have emerged as potential biomarkers in various diseases, including cancer. This study aimed to evaluate the expression of lncRNAs HOTTIP and HOTAIR in CNS patients and healthy contr [...]

by Sandra Kiessling

Received: 06 September 2024;  Published: 15 January 2025;  doi: 10.21926/aeer.2501006

The World climate is changing, with a great impact on global food production systems. Extreme weather events, floods, wildfires and draughts are phenomena of disrupted previously stable natural weather patterns, which are vital for crop production and animal husbandry alike. Most of the World’s food is produced in temperate climatic zones rich in arable land and those are affected by the increasing unpredictability of previously naturally occurring seasons and weather conditions. This work aims to provide a possibl [...]

by Giuseppe Merra  , Giada La Placa  , Marcello Covino  , Marcello Candelli  , Antonio Gasbarrini  and Francesco Franceschi

Received: 06 November 2024;  Published: 28 February 2025;  doi: 10.21926/obm.neurobiol.2501273

Interactions in the gut-brain crosstalk have led to the development of an entirely new concept: the "microbiota-gut-brain axis". Microbiota has gained considerable attention in relation to disorders of a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, and mood disorders. This review aims to summarize the recent trends and insights into the role and consequences of gut microbiota in brain health and pediatric neurological disorders. Dysbiosi [...]

by OBM Hepatology and Gastroenterology

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.hg.2101054

The editors of OBM Hepatology and Gastroenterology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificat [...]

by Anita Padmanabhanunni  and Tyrone Pretorius

Received: 26 April 2023;  Published: 25 September 2023;  doi: 10.21926/obm.neurobiol.2303184

The COVID-19 pandemic was characterized as a continuous traumatic stressor and associated with high levels of posttraumatic stress disorder (PTSD). This study examines the associations between demographic factors, COVID-19-related factors (fear of COVID-19 and perceived stress), and PTSD, as well as the associations between PTSD and indices of mental health. The participants in the study were university students (n = 322) who completed the PTSD Checklist for the Diagnostic and Statistical Manual-5 (DSM-5), the Fear [...]

by Lucília S. Ribeiro

Received: 19 August 2024;  Published: 22 August 2024;  doi: 10.21926/cr.2403012