by Abubakar Siddiq Salihu  , Wan Mohd Nuzul Hakimi Wan Salleh  , Nurunajah Ab Ghani  , Mohd Hafiz Arzmi  , Bunleu Sungthong  and Ravikumar Kapavarapu

Received: 05 March 2025;  Published: 27 April 2025;  doi: 10.21926/obm.neurobiol.2502286

The Myristicaceae family, particularly the Knema genus, is renowned for its diverse bioactive compounds, including lignans, flavonoids, and phenolics. This study explores the phytochemical profile of Knema hookeriana Warb. leaves and evaluates their potential as acetylcholinesterase (AChE) inhibitors. Phytochemical extraction was performed using a cold maceration method with a polarity-gradient solvent system (hexane, ethyl acetate, and methanol). The isolated compounds were purified through chromatographic techniq [...]

by Faten Dhawi  and Shefin Basheera

Received: 12 March 2025;  Published: 25 May 2025;  doi: 10.21926/obm.genet.2502295

Jatropha curcas L., a medicinal shrub renowned for its diverse phytochemicals, has been traditionally used to treat various ailments, including ulcers, neoplasms, and dermatological conditions. Despite its pharmacological promise, its potential against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) remains unexplored. This study investigates the antiviral efficacy of J. curcas phytochemicals targeting the SARS-CoV-2 main protease (Mpro), a critical enzyme for viral replication, using advanced computat [...]

by Yasuhiro Kotera  , Noelia L. Martínez-Rives  , Muhammad Aledeh  , Habib Adam  , Julie Beaumont  , Rory Colman  , Jessica Eve Jackson  , Christian Veasey  , Lucie-May King  , Tracey Harrington  , Elaina Taylor  , Ann-Marie Edwards  , Gabby A. A. Rothwell-Blake  , Adewale Allen Sokan-Adeaga  , Gillian H.T. Liu  , Kenneth Curley  , Matthew Cotterill  , Malik Dimbei Halidu  , Juliet Wilkes  , Aiesha Carew Tofani  , Samantha Greaves  , Rob Hughes  , Annabel Rushforth  , Ann Kirkman  , Michelle Brooks-Ucheaga  and Kristian Barnes

Received: 14 February 2024;  Published: 22 August 2024;  doi: 10.21926/obm.icm.2403048

This short report presents an international research group, Research Ensemble for Advancement in Cross-cultural Healthcare (REACH). REACH is an independent research group, and no one is paid to do research for REACH. All members participate because they are intrinsically motivated to pursue cross-cultural healthcare. REACH consists of 28 healthcare workers and educators from 13 countries, researching about cross-cultural issues in healthcare (18 publications on average per year as of February 2024). REACH is multi- [...]

by Sabrine Mekni  , Lamia Torjemane  , Malek Khayati  , Dorra Belloumi  , Rimmel Yosra Kanoun  , Insaf Ben Yaiche  , Rihab Ouerghi  , Ines Turki  , Saloua Ladeb  , Tarek Ben Othman  and Nour Ben Abdeljelil

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...]

by Andrea Bellieni  , Beatrice Di Capua  , Emanuele Rocco Villani  , Luca Tagliaferri  , Domenico Fusco  , Maria Antonietta Gambacorta  , Francesco Presta  , Serena Bracci  , Vincenzo Valentini  , Francesco Landi  and Giuseppe Ferdinando Colloca

Received: 17 November 2022;  Published: 13 June 2023;  doi: 10.21926/obm.geriatr.2302238

New technologies, aging-related changes, and evolution in patients' needs have led to a new scenario in all oncological fields in front of which we have to move on. Technological progress has made it possible to increase the number of patients treated, including elderly patients and generally those at higher risk of toxicity. However, this scenario has led to new problems requiring new skills to be addressed. For this reason, Gemelli-ART (Advanced Radiation Therapy) of Fondazione Policlinico Universitario A. Gemell [...]

by James David Adams

Received: 22 August 2023;  Published: 11 January 2024;  doi: 10.21926/obm.icm.2401009

Many websites are dedicated to educating the public about chronic pain and its management. The majority of these websites say there is no cure for chronic pain, but encourage patients to try exercise, diet, stress reduction and other techniques to decrease the severity of chronic pain. Patients are also taught to use oral or injected drugs to treat their chronic pain. This can be dangerous and leads to adverse events and death in some patients. The majority of these websites teach patients that chronic pain comes f [...]

by Brittany Montgomery  , Calvin Mammen  and Matt Golden

Received: 18 October 2024;  Published: 09 May 2025;  doi: 10.21926/obm.geriatr.2502311

Assistive technology (AT) interventions have shown promising results in supporting cognitive, social, and physical activities in persons living with dementia (PLWD) and their caregivers. Despite strong evidence of the effectiveness of AT, PLWD and their caregivers can disengage with the technology after it is used for a time – i.e., the “stickiness challenge”. Diminished use of AT reduces the opportunity for it to have optimal impact. We asked whether the opportunity to engage in cognitive games may enhance continu [...]

by Andrés R. Latorre-Rodríguez  , Devika Sindu  , Sumeet K. Mittal  and Ashwini Arjuna

Received: 23 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.transplant.2402219

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii) assess the association between pepA and isolation of typical gastrointestinal microorganisms from BAL fluid, and iii) explore the accuracy of using pepA concentration as a biomarker of ACR. After IRB approval, we conducted a retrospective observational study analy [...]

by Mohammad-Reza Ghasemi  , Maryam Mirahmadi  , Hadi Bayat  , Morteza Sheikhi Nooshabadi  , Sanaz Jamshidi  , Shadab Salehpour  , Reza Mirfakhraie  , Fatemeh Fazeli  , Mohammad Miryounesi  and Milad Gholami

Received: 22 November 2024;  Published: 14 April 2025;  doi: 10.21926/obm.genet.2502291

Knobloch Syndrome (KS) is a rare genetic disorder characterized by ocular abnormalities and central nervous system (CNS) defects, which are attributed to collagenopathy. The primary gene implicated in KS is COL18A1, which encodes the alpha chain of type XVIII collagen. This type of collagen functions as a proteoglycan, predominantly located in the basement membrane of human tissues. This study examined an Iranian female presenting with symptoms of horizontal nystagmus, strabismus, and suspected vision loss, with a [...]

by Chandra Sekhar Devulapalli

Received: 07 July 2021;  Published: 22 July 2021;  doi: 10.21926/obm.hg.2103059

Non-celiac gluten sensitivity (NCGS) is a debatable condition that affects less than 6% of children. The absence of specific diagnostic markers and standardized diagnostic procedures make the diagnosis of NCGS challenging, covering patients with different and varied symptoms. Generally, the parents of small and younger children introduce a gluten-free diet (GFD) based on their personal experiences and expectations. Additionally, a “fad component” exists, contributing to the recent rise in the popularity of GFD. Thu [...]

by Jennifer Vasquez  , Michele Quill  and Chase Bossart

Received: 17 January 2025;  Published: 14 March 2025;  doi: 10.21926/obm.icm.2501014

In this qualitative study, the impact of therapeutic Viniyoga on health and healing was explored from the perspective of 14 Viniyoga therapists who were interviewed on their perceptions of how yoga therapy contributes to the health and healing of their clients. A philosophical definition of Therapeutic Viniyoga was developed. Three themes related to health and healing from the perspective of Viniyoga therapists were identified using NVivo and Interpretative Phenomenological Analysis procedures: The definition of he [...]

by Recent Progress in Science and Engineering Editorial Office

Received: 22 June 2025;  Published: 23 June 2025;  doi: 10.21926/rpse.2502010

by Anita Padmanabhanunni  and Tyrone Pretorius

Received: 26 April 2023;  Published: 25 September 2023;  doi: 10.21926/obm.neurobiol.2303184

The COVID-19 pandemic was characterized as a continuous traumatic stressor and associated with high levels of posttraumatic stress disorder (PTSD). This study examines the associations between demographic factors, COVID-19-related factors (fear of COVID-19 and perceived stress), and PTSD, as well as the associations between PTSD and indices of mental health. The participants in the study were university students (n = 322) who completed the PTSD Checklist for the Diagnostic and Statistical Manual-5 (DSM-5), the Fear [...]

by Leila Zirak  and Reza Khakvar

Received: 31 August 2023;  Published: 04 December 2023;  doi: 10.21926/obm.genet.2304204

Russian olive trees showing witches’-broom disease symptoms in urban green spaces and orchards in northwest Iran were sampled for phytoplasma detection. PCR assays and Sanger sequencing of 16S rRNA gene confirmed that ‘Ca. Phytoplasma asteris’ was associated with Russian olive witches’-broom disease. For genomic characterization of phytoplasma associated with disease, the total DNA of an infected tree was analyzed by Illumina next-generation sequencing (NGS). The NGS analysis generated 46011 [...]

by Aileen M. Lynch  , Gabrielle McKee  , Fintan Sheerin  , Jean-Luc Bosson  , Monique Epstein  , Ariane Girault  , Carole Rolland  , Mary Harkin  , Ciaran McKinney  and Pierre Gillois

Received: 05 June 2024;  Published: 17 December 2024;  doi: 10.21926/obm.geriatr.2404292

While the facilitators/barriers for the initiation of physical activity (PA) are well documented, there is less known about these facilitators/barriers for maintenance of PA in the older population in general and not following an intervention. This study aimed to explore older adults’ perspectives on the facilitators/barriers to maintaining PA. The study used descriptive qualitative design, with three focus groups, one in Ireland and two in France. Participants were community-dwelling older adults (≥60 years) 66% w [...]

by Atsushi Naganuma  , Satoru Kakizaki  , Takashi Hoshino  , Toshiyuki Tanaka  , Tetsushi Ogawa  , Shuya Sawada  , Satomi Adachi  , Yusuke Ogawa  , Toyoshi Sasaki  , Ken Sato  , Hitoshi Takagi  and Toshio Uraoka

Received: 25 September 2018;  Published: 26 December 2018;  doi: 10.21926/obm.hg.1804011

Background: Branched-chain amino acids (BCAA) are nutrients with a bitter taste, which causes low compliance in patients who need BCAA supplementation. Moreover, chronic liver disease is frequently complicated by taste impairment. The present study was designed to improve patient noncompliance regarding nutrients in liver disease. Methods: A taste questionnaire was administered to healthy controls, chronic hepatitis patients, and cirrhotic patients. Eleven different flavored powders that can be added to BCAA nutri [...]

by Lucília S. Ribeiro

Received: 19 August 2024;  Published: 22 August 2024;  doi: 10.21926/cr.2403012

by Víctor Escrich  , Angela Martinez Herreros  , Berta Lapeña  , Marta Mayorga  , Antonio Cuadrado  , Javier Crespo  and Emilio Fabrega

Received: 01 March 2021;  Published: 21 June 2021;  doi: 10.21926/obm.hg.2102057

The reactivation of the Varicella-zoster virus (VZV) is a rare cause of acute gastritis in adults. About 30 cases have been reported in the literature, mostly with immunocompromised patients and mainly after bone marrow transplantation or during the development of malignant hematological diseases. Clinically, it is usually accompanied by cutaneous manifestations. Here, we studied a case of VZV gastritis in a liver transplant (LT) patient. We described the main symptoms, endoscopic findings, histologic changes, and [...]

by Nasrin Motazedian  , Masoud Mokhtari  , Negar Azarpira  , Kimia Falamarzi  , Mohsen Mohammadi  , Seyed Mohsen Dehghani  , Sarina Pourjafar  , Maryam Ataollahi  , Elaheh Esfandiari  , Mahdokht Hossein-Aghdaie  , Seyed Ali Malekhosseini  , Tayebeh Kazemi  and Mahintaj Dara

Received: 05 May 2024;  Published: 04 June 2024;  doi: 10.21926/obm.transplant.2402217

Crigler-Najjar syndrome (CNS) is a rare autosomal recessive disorder characterized by impaired bilirubin metabolism, leading to neurotoxic unconjugated bilirubin accumulation. Liver transplantation remains the only effective treatment, highlighting the need for novel diagnostic and therapeutic approaches. Long non-coding RNAs (lncRNAs) have emerged as potential biomarkers in various diseases, including cancer. This study aimed to evaluate the expression of lncRNAs HOTTIP and HOTAIR in CNS patients and healthy contr [...]

by Tayseer A. S. Idrees  and Ibtisam E. M. El Zubeir

Received: 06 April 2024;  Published: 27 April 2025;  doi: 10.21926/rpn.2502009

This study was conducted to investigate the effect of sources. locations and seasons (late summer and winter) on the chemical composition of cow milk collected from Khartoum State. The samples were collected randomly in the morning or the evening. Two hundred and seventy milk samples were collected from farms (90 samples), groceries (90 samples) and vendors (90 samples) in Khartoum State during the late summer and winter seasons, 135 samples each. The milk samples were kept in cool cracked ice and transported immed [...]

by Sintija Strautmane  , Arturs Balodis  , Klavs Smidrovskis  and Kaspars Auslands

Received: 10 January 2024;  Published: 13 March 2024;  doi: 10.21926/obm.neurobiol.2401214

Rhinorrhea is a possible complication after different types of traumatic brain injury or neurosurgical procedures, such as skull base operations. Pneumocephalus is a rarely noted complication after severe traumatic brain injury, and it may be accompanied by meningitis and ventriculitis, especially when treatment has been delayed. Treatment of these entities includes conservative and surgical approaches. Pneumocephalus may result in neurologic disturbances threatening a life. Therefore, active patient management wit [...]

by Mohammad Forhad  , Mehedi Hasan Shakil  , Md.Rashidul Islam  , Muhammed Y. Worku  and Md Shafiullah

Received: 20 June 2023;  Published: 30 January 2024;  doi: 10.21926/jept.2401003

The prolonged presence of low-frequency oscillation (LFO) in power system networks (PSN) poses a significant threat to their stability. Hence, engineers and researchers have continuously developed effective strategies to mitigate the issue and enhance the stability of the PSN. This article proposes a new approach using the African Vultures Optimization Algorithm (AVOA) to design robust Power System Stabilizers (PSS) and enhance the LFO damping in multi-machine networks. The damping ratio-based objective function mi [...]

by Sandra Kiessling

Received: 06 September 2024;  Published: 15 January 2025;  doi: 10.21926/aeer.2501006

The World climate is changing, with a great impact on global food production systems. Extreme weather events, floods, wildfires and draughts are phenomena of disrupted previously stable natural weather patterns, which are vital for crop production and animal husbandry alike. Most of the World’s food is produced in temperate climatic zones rich in arable land and those are affected by the increasing unpredictability of previously naturally occurring seasons and weather conditions. This work aims to provide a possibl [...]

by Katie Lahue  , Eliana Rivera  and Sara Schmidt

Received: 03 June 2023;  Published: 24 October 2023;  doi: 10.21926/obm.icm.2304044

The COVID-19 pandemic presented a host of issues for hospitalized patients including increased anxiety, fear, isolation, and depression [1]. Expressive Therapies have been used in the pediatric medical setting for decades to support patients and families with coping, expression, processing, and rehabilitation [2,3,4,5]. Additionally, some studies suggest that Expressive Therapies were effective in helping ease the increase in mental health symptoms that occurred during the pandemic. During the pandemic the expressi [...]

by Adam Resnick  , Alicia Bergman  , Rebecca Oberman  , Stephanie L. Taylor  , Emmeline Chuang  , Kelsey Cummings  and Evelyn T. Chang

Received: 20 December 2023;  Published: 31 January 2024;  doi: 10.21926/obm.icm.2401012

The Veterans Health Administration (VA) offers complementary and integrative health (CIH) therapies to Veterans with chronic pain and opioid use disorder (OUD). While CIH therapies have known benefits for chronic pain, less research exists on its use for patients with OUD. In this qualitative study, we aimed to assess provider and patient perceptions of CIH therapies for Veterans with OUD. We interviewed 45 providers involved in OUD care and 17 Veterans with OUD from five VA medical centers as part of a larger mixe [...]