by Stefania Policicchio  , Emma L Dempster  and Therese M Murphy

Received: 20 June 2018;  Published: 06 October 2018;  doi: 10.21926/obm.genet.1804039

Suicide is the second leading cause of death globally among young people and the tenth leading cause of death across all ages. Approximately 800,000 people die by suicide every year representing a significant global health burden. Despite this burden, the molecular pathology of suicide remains poorly understood. A number of recent studies have shown that epigenetic alterations are associated with suicidal behaviour. These epigenetic mechanisms, which act to regulate gene expression via modifications to DNA, histone [...]

by Kikuko Hayamizu  , Tomoyuki Haishi  , Yasuhiko Terada  , Kunimitsu Kataoka  and Junji Akimoto

Received: 24 January 2023;  Published: 03 April 2023;  doi: 10.21926/rpm.2302014

Pulsed field-gradient (PFG) NMR spectroscopy was applied to thin disk samples (0.5, 1 and 2 mm thick, 4 mm diameter) of LLZO-Ta (Li6La3Zr1.5Ta0.5O12) single crystal. We have measured the diffusion of 7Li in thin pellets (0.5 to 3 mm thick) of NASICON-type LAGP powder and found that the Li+ diffuses preferentially in the thicker direction. In this study, we placed 1 mm thick, 4 mm diameter disk-shaped single crystals vertically, i.e., parallel to the PFG direction. We found that 7Li ions diffuse similarly as in rod- [...]

by Andreas Miles-Novelo  and Craig A. Anderson

Received: 30 August 2022;  Published: 24 May 2023;  doi: 10.21926/aeer.2302034

As the climate crisis has progressed, scientists have begun to ask, "How does a rapidly warming ecosystem impact human behavior?" As aggression scholars and non-professional environmentalists, it has become increasingly clear that the impact of the climate crisis, without intervention, will dramatically increase humans' exposure to risk factors known to cause aggressive and violent behavior. This article describes a model that explains the indirect and direct effects of the climate crisis on aggression and violence [...]

by Yi Song  , Carlos Rivera  , Jiayu Mai  , Annie Sun  and Weihan Li

Received: 23 March 2020;  Published: 22 May 2020;  doi: 10.21926/obm.genet.2002110

The majority of the secretory and transmembrane proteins are folded in the endoplasmic reticulum (ER). When unfolded proteins accumulate in the ER, a collective of signalling pathways, termed the unfolded protein response (UPR), are activated to restore the ER protein folding homeostasis. The most evolutionarily conserved branch of UPR is mediated by the kinase/endoribonuclease Ire1. Ire1 mediates a cytosolic non-conventional mRNA splicing reaction of HAC1 mRNA in yeast and XBP1 mRNA in mammalian cells. The spliced [...]

by Komeil Mirzaei Baboli  and Sumeet K. Mittal

Received: 29 October 2020;  Published: 05 February 2021;  doi: 10.21926/obm.geriatr.2101157

A 64-year-old, cachectic man with body mass index (BMI)

by Jessica Scher Lisa  and Eric Shyman

Received: 24 October 2019;  Published: 02 March 2020;  doi: 10.21926/obm.neurobiol.2001051

With an increasing prevalence of children with Autism Spectrum Disorder (ASD) in schools, teachers are in need of different effective ways to educate these individuals who have distinctly different needs and modalities of experience. One area that has been explored is neuroeducation, or using findings from neuroscientific research to inform classroom practice. Neuroscientific findings appear to center on two main themes of neurological differences among children with ASD: sensory processing and emotional processing [...]

by Melissa Sandler  , Sulaiman Almohaish  and Gretchen M. Brophy

Received: 11 February 2021;  Published: 16 March 2021;  doi: 10.21926/obm.geriatr.2101161

Pharmacological management of intracerebral hemorrhage in adult patients over 65 years of age requires special considerations due to differing clinical presentations, underlying organ dysfunction, and more complex medical histories and medication profiles. A literature review of articles focusing on the age-specific pharmacological management of intracerebral hemorrhage was conducted. Treatment approaches and clinical outcomes specific to older adults were evaluated and therapeutic considerations for this populatio [...]

by Sam T Briggs  , Mary Beth B Monroe  , Mark A Weizbicki  , Sayyeda Marziya Hasan  and Duncan J Maitland

Received: 05 April 2021;  Published: 25 June 2021;  doi: 10.21926/rpm.2102025

Shape memory polymers (SMPs) are highly attractive materials for medical devices. Specifically, SMP foams are currently being used as embolic devices in peripheral and cerebral vascular applications. To ensure the proper function and safety of these materials in their intended applications, it is important to understand how processing treatments, such as aging, sterilization, and foam composition can influence their degradation. Here, SMP foams were treated with industry relevant processing parameters, and the infl [...]

by Lindy A. Kilik  and Robert W. Hopkins

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston Standardized Cognitive Asse [...]

by Igor Val Danilov  , Sandra Mihailova  and Araksia Svajyan

Received: 05 July 2022;  Published: 28 September 2022;  doi: 10.21926/obm.neurobiol.2203137

This study aims to observe the differences in the shared intentionality magnitude in mother-child dyads with neurotypical (NT) children and neurodivergent (ND) children aged 3-6 years. The quality of shared intentionality in infancy is associated with cognitive development. Our results showed that ND children scored six times higher (on average) in quiz-test than NT children. Children with difficulties in interaction (ND children) are more likely to use shared intentionality in conversation than NT children. We bel [...]

by Kosuke Shigematsu  , Yukiko Mikami  , Mamiko Shinsaka  , Masanobu Kinoshita  and Yasushi Takai

Received: 29 June 2022;  Published: 28 March 2023;  doi: 10.21926/obm.genet.2301179

Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic disease often resulting in more severe symptoms in affected children. The number of CTG repeats is reportedly related to congenital myotonic dystrophy 1 (CDM) severity. In this study, we aimed to clarify whether the number of CTG repeats can predict the severity of symptoms in children with CDM. This retrospective study examined 14 women with DM1 and their 14 children diagnosed with CDM. There were 11 CDM and 3 non-CDM patients. The correlation betwee [...]

by Hsueh-Fen S. Kao  and Maria A. Amaya

Received: 19 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903065

Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families for care. Methods: Review published caregiving models for older adults in H/L populations. Results: Gradual and inevitable acculturation of H/L caregivers to U.S. social customs, and the mutual relationship within the [...]

by Fabrice Debbasch

Received: 15 October 2019;  Published: 06 January 2020;  doi: 10.21926/rpm.2001002

A relativistic Wigner function for free Discrete Time Quantum Walks (DTQWs) on the square 2D space-time lattice is defined. The transport equation obeyed by the relativistic Wigner function is derived in terms of discrete derivatives and degenerates in the continuum limit into the transport equation obeyed by the Wigner function of 2D Dirac fermions. The first corrections to the continuous equation induced by the discreteness of the lattice are also determined and the similarities with non-quantum relativistic tran [...]

by Im Quah-Smith

Received: 09 May 2018;  Published: 25 June 2018;  doi: 10.21926/obm.icm.1802012

The Auricular approach to diagnostics and therapeutics has gained momentum over the last 15 years. Battlefield Acupuncture has taken on a life of its own and has been adopted into NATO and even been introduced into neonatal intensive care. It is time to take on the challenge of Auricular Medicine - the application of the neurophysiological phenomenon referred to as the Vascular Autonomic Signal or VAS to identify active ear sites in Auricular interventions. It is time to utilize the VAS in therapeutics, recognizing [...]

by Hironori Takagi  , Koichi Kakimoto  , Daishuke Mori  , Sou Taminato  , Yashuo Takeda  , osamu yamamoto  and Nobuyuki Imanishi

Received: 12 January 2021;  Published: 24 February 2021;  doi: 10.21926/jept.2101010

The demand for high energy density rechargeable batteries beyond lithium-ion batteries has increased for electric vehicles. In the present study, a novel high energy density rechargeable aqueous lithium battery was proposed. The battery was composed of a lithium metal anode, a lithium-stable non-aqueous electrolyte, a water-stable lithium-ion conducting solid electrolyte of Li1.4Al0.4Ge0.2Ti1.4(PO4)3-epoxy-TiO2 separator, and a hydroquinone sulfonic acid (HQS)/benzoquinone sulfonic acid (BQS) redox couple in an aqu [...]

by Masahiro Sato  , Kazunori Morohoshi  , Masato Ohtsuka  , Shuji Takabayashi  , Emi Inada  , Issei Saitoh  , Satoshi Watanabe  and Shingo Nakamura

Received: 17 September 2023;  Published: 12 December 2023;  doi: 10.21926/obm.genet.2304207

Gene-engineered animals created using gene-targeting technology have long been recognized as beneficial, valid, and valuable tools for exploring the function of a gene of interest, at least in early 2013. This approach, however, suffers from laborious and time-consuming tasks, such as the production of successfully targeted embryonic stem (ES) cells, their characterization, production of chimeric blastocysts carrying these gene-modified ES cells, and transplantation of those manipulated blastocysts to the recipient [...]

by Zheer Al-Mashhadi  , Rikke Viggers  , Rasmus Fuglsang-Nielsen  , Bente Langdahl  , Peter Vestergaard  , Søren Gregersen  and Jakob Starup-Linde

Received: 02 April 2020;  Published: 18 June 2020;  doi: 10.21926/obm.geriatr.2002123

Type 2 diabetes mellitus (T2DM) and osteoporosis are two major public health concerns worldwide, contributing to morbidity and mortality in the elderly. Aging is one of the most significant risk factors for low bone mass, bone fragility, and fractures. Among the several comorbidities that affect the elderly with diabetes, increased fracture risk is a relatively recently discovered complication. Generally, individuals with T2DM exhibit higher bone mineral density, which complicates the assessment of fracture risk. D [...]

by Angharad Vernon-Roberts  and Andrew S Day

Received: 23 January 2022;  Published: 19 April 2022;  doi: 10.21926/rpn.2202013

Children with inflammatory bowel disease (IBD) have a high prevalence of vitamin D insufficiency secondary to factors such as malabsorption and decreased intake. In recent years the benefits of optimal vitamin D status have been highlighted for their potential to improve the disease course and long-term outcomes in this population. Clinical benefits have been seen to bone health, the immune system, and gut health, with further improvements to disease and treatment outcomes. Recommendations for vitamin D treatment p [...]

by Pierfrancesco Morganti  , Gianluca Morganti  , Maria Beatrice Coltelli  , Wladimir E Yudin  , Hong-Duo Chen  and Alessandro Gagliardini

Received: 16 March 2022;  Published: 23 May 2022;  doi: 10.21926/aeer.2202021

Approximately 75% of textile waste is generated annually worldwide, as there is a dearth of viable recycling strategies. It has been estimated that textile industries can be responsible for approximately 20% of global water pollution. As a consequence, if not properly managed, the cost of waste management of textile waste will be trillions of dollars annually. Moreover, the generated wastes are detrimental to the environment and public health. On the other hand, there is a possibility that the majority of the waste [...]

by Alberto Dubbini

Received: 02 April 2023;  Published: 07 September 2023;  doi: 10.21926/obm.icm.2303035

This article aims to analyze how Western researchers can be influenced by their epistemic and ethical foundations, which are also expressed through a culturally shared idea of therapy, and how this influence can significantly hinder the understanding of a different cultural reality and its resources in terms of knowledge and practices. While examining a collection of research cases in the field of psychedelic therapy, the present paper focuses on the obstacles created by ethical and epistemic conflicts in the mind [...]

by Laura Privalle  , Patricia Back  , Apurv Bhargava  , Zach Bishop  , Krystal Cisneros  , Isabelle Coats  , Ine Criel  , Lien Dhondt  , Travis Draughn  , Barb Fowler  , Brad Franklin  , Durba Ghoshal  , Jim Lor  , Jennifer Massengil  , Sofie Moens  , Tyson Mooney  , Dannyel Nelson  , Karolien Peeters  , Sashi Sathischyandra  , Caroline Staut  , Yoonhui Sung  , Ann Tuttle  , Annelies Van Hoecke  , Annelies Van Raemdonck  , Marie-Laure Verdegem  , Steven Verhaeghe  , Shane Walsh  , Ann Wierckx  , Qiang Zhao  and Rozemarijn Dreesen

Received: 11 September 2020;  Published: 02 December 2020;  doi: 10.21926/obm.genet.2004120

Demonstration of the stability of traits newly introduced into a plant genome via genetic engineering approaches comprise a significant portion of the safety assessment that these products undergo prior to receiving the requisite regulatory approvals enabling commercial authorization. Different regions of the world have different regulatory requirements and many ask similar questions from multiple and overlapping perspectives. The entire central dogma, that is stability at the DNA level, mRNA level and protein leve [...]

by Zoi Portokalidou  , Anna Huysse-Gaytandjieva  and Madelon L. Peters

Received: 09 January 2022;  Published: 12 July 2022;  doi: 10.21926/obm.icm.2203027

Hashimoto thyroiditis (HT) is an autoimmune disease affecting mainly middle-aged women. Hormonal replacement is the most common therapy; however, it tackles only the functionality of the thyroid and not the autoimmunity components. Thus, patients experience persistent somatic and psychological symptoms, thereby affecting their quality of life. The cause of HT remains uncertain. Primary evidence suggests that adverse experiences in childhood are associated with autoimmune disease manifestation in adulthood; therefor [...]

by Brenda T. Mbibueh  , Reeves M. Fokeng  and Suiven J.P. Tume

Received: 29 September 2021;  Published: 30 December 2021;  doi: 10.21926/aeer.2104038

Land-use change is one of the main indicators of soil quality. Soil physical and chemical properties vary with land use change and altitude as inferred from transect surveys and toposequences. Soil nitrogen, phosphorus, and potassium (NPK) are essential macronutrients for plant growth and soil nutrient balance. Their presence in the soil in appropriate quantities is important for maintaining crop yields and farmers income, particularly in developing countries where resources of soil chemical additives may be limite [...]

by Xiang Li  , Yuan Xue  , Ryan Dehoff  , Costas Tsouris  and Patricia Taboada-Serrano

Received: 09 April 2020;  Published: 09 May 2020;  doi: 10.21926/jept.2002007

Hierarchically-structured, electro-catalysts consisting of a titanium core with controlled macro-porosity and a thin titania surface-layer with controlled nano-porosity were synthesized via combination of additive manufacturing and in-situ anodization. The electrodes were tested for hydrogen evolution reaction and depicted competitive electro-catalytic activities, with Tafel slopes between 40 and 56 mV dec-1. The electrodes also depicted competitive onset and over potentials when compared with other electrode alter [...]

by Ilaria Scarpelli  , Fabienne Marcelli  , Francesca Mattioli  and Jacqueline Schoumans

Received: 01 April 2019;  Published: 09 August 2019;  doi: 10.21926/obm.genet.1903088

With the advent of next-generation sequencing (NGS), genomic profiling of tumors has been gradually introduced into the clinical setting and has become a standard in cancer care. NGS allows convenient, rapid, and inexpensive sequencing and the commercially available NGS panels enable the detection of single or global genomic alterations of germline and somatic origin. Today, genomic mutation profiling using NGS is indispensable for disease evaluation and prediction of prognosis or responsiveness to cancer therapy. [...]