by Dafné Silva  , Laís Nerys  , Carlos Silva  , Elizabeth Borba  , Tonny Leite  , Teresinha Silva  and Amanda Sena

Received: 27 May 2022;  Published: 25 August 2022;  doi: 10.21926/cr.2203024

Macambira plant (Bromelia laciniosa Mart. Ex Shult. & Schult. f.) is a species belonging to the family Bromeliaceae, which is distributed widely in the hinterlands of northeastern Brazil, from Bahia to Piauí states. The plants of this species contain an enzyme complex named bromelain, which has great potential for therapeutic applications. In the present study, bromelain derived from Bromelia laciniosa leaves was assessed for its thermodynamic properties and in vitro cytotoxic and healing activities. Bro [...]

by Éilish A. Burke  , Rachael Carroll  , Angela W. Ding  , Melisa Yaman  , J. Bernard Walsh  , Philip McCallion  and Mary McCarron

Received: 23 June 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104182

Globally between 30-40% of all osteoporotic fractures occur among men, with a quarter of all hip fractures, the most serious complication of osteoporosis, occurring in men. Among men of 50 years of age or older, osteoporotic fracture risk reaches an alarming 20%. What is of great concern is that associated mortality is greater among men when compared with women. For hip fractures specifically, mortality for men is two to three times that in women which may be attributed to the fact that osteoporosis is often consid [...]

by Carol Tran  and Laurence J. Walsh

Received: 28 September 2021;  Published: 26 November 2021;  doi: 10.21926/rpm.2104046

Subsurface remineralization can be promoted by the topical application of nanoparticles of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). To assess changes in enamel white spot lesions, an in situ proof-of-concept investigation was performed using 5 subjects (all of whom were healthy young adults) with a cross-over study design. Custom orthodontic brackets were attached to the buccal surfaces of the maxillary second premolar and first molar teeth. Each bracket had a recess that held a slab of enamel w [...]

by Lisa M. Manderino  , Mary Beth Spitznagel  , Divya Yogi-Morren  , John P. Kirwan  , Sangeeta Kashyap  and John Gunstad

Received: 01 August 2018;  Published: 05 December 2018;  doi: 10.21926/obm.geriatr.1804023

Background: Type 2 diabetes (T2DM) and metabolic syndrome are linked to pathological changes in the brain and increased likelihood of cognitive impairment. 25-hydroxyvitamin D insufficiency is commonly found in this population and is associated with cognitive dysfunction in other patient groups. This preliminary study sought to examine whether 25-hydroxyvitamin D levels are is associated with cognitive deficits in this population. Methods: Twenty individuals with T2DM and metabolic syndrome (n = 20, aged 45 to 72) [...]

by Rohman Hikmat  , Iyus Yosep  , Efri Widianti  , Suryani Suryani  , Aat Sriati  and Icih Susanti

Received: 20 July 2024;  Published: 12 October 2024;  doi: 10.21926/obm.neurobiol.2404249

To describe the application of the Stuart Stress Adaptation and Nola Pender Models in mental nursing care for a patient with schizophrenia and risk of violent behavior. This research method used case studies. The sample is one patient with schizophrenia. Data collection is done through direct observation, interviews, and patient medical records. The results showed that the client showed a major nursing problem in the form of risk of violent behavior. Predisposing factors included passive childhood experiences and s [...]

by Naoaki Sakata  , Gumpei Yoshimatsu  and Shohta Kodama

Received: 02 October 2020;  Published: 27 November 2020;  doi: 10.21926/obm.transplant.2004127

Islet transplantation is a cellular replacement therapy for severe diabetes mellitus. Although the clinical outcome of islet transplant has been improving, the transplant efficacy of this treatment is not superior to that of pancreatic organ transplantation, a similar transplant therapy. Various factors have been characterized as ‘islet transplantation specific’, which includes lack of revascularization and ischemia, innate inflammation, or autoimmunity, affect the therapeutic outcome of this treatment. Among them, [...]

by Martine S. Bosma  , Monique A.A. Caljouw  , Jacqueline K. Benfield  , Laura Edwards  , Tanja C.W. Nijboer  and Wilco P. Achterberg

Received: 07 December 2020;  Published: 19 March 2021;  doi: 10.21926/obm.geriatr.2101163

Visuospatial neglect (VSN) adversely impacts both the length of rehabilitation and activities of daily living (ADL) of patients after stroke and can reduce their participation in community activities. Therefore, it is important to assess VSN after stroke in neurorehabilitation facilities. The process of assessing VSN comprehensively in current geriatric rehabilitation remains unclear. This study examined the process of VSN in post-stroke assessment emphasizing the details of the (systematic) routines and structure [...]

by Yue Qiu  , Yinqian Kang  , Hao Liu  and Ibtesam Hilmi

Received: 12 May 2024;  Published: 30 August 2024;  doi: 10.21926/obm.transplant.2403224

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and the scarcity of available donor livers, MP offers a practical solution for recovering high-risk grafts and increasing the number of potentially usable donor organs. Furthermore, testing and administering novel therapies to allografts may also become advanta [...]

by Angela Q Maldonado  , Kristoffer Sjöholm,  , Joshua Lee  , Håkan Olsson  , Christian Kjellman  and Darren E Stewart

Received: 01 April 2021;  Published: 03 June 2021;  doi: 10.21926/obm.transplant.2102143

Prioritization in the US Kidney Allocation System (KAS) has led to an improvement in the rates of transplantation in highly sensitized (HS) patients. However, there is a subset of HS patients who are at a disadvantage, despite prioritization under KAS. The purpose of this study was to describe the transplant rate (TR) by calculated panel reactive antibody (CPRA) of HS candidates before and five years post-KAS to characterize their access to deceased donor transplants and quantify the number of HS candidates who are [...]

by Anikka M. Swaby  and Luis B. Agellon

Received: 20 December 2021;  Published: 26 May 2022;  doi: 10.21926/rpn.2202014

Microbes have been part of the diet throughout human history. In the evolution of food preservation practices, some techniques inadvertently leveraged microbial activity not only to extend the storage life but also to enhance the properties and nutritive value of foods. In the last century, a variety of bacterial species (referred to as probiotics) were found to confer health benefits to the host. The advent of high-throughput sequencing methods facilitated improved surveillance of conventional probiotics within gu [...]