by Cristina Bagacean  , Anne Bordron  , Tempescul Adrian  , Jean Christophe Ianotto  , Gaelle Guillerm  , Wesley H Brooks  , Marie-Anne Couturier  , Mihnea Zdrenghea  , Christian Berthou  and Yves Renaudineau

Received: 05 June 2018;  Published: 14 December 2018;  doi: 10.21926/obm.genet.1804054

Epigenetic dysregulation is present in both myeloid and lymphoid disorders, with important differences reported between myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), on one hand, and chronic lymphocytic leukemia (CLL), on the other. Qualitative differences are reported in MDS/AML with gene fusions (e.g. TET1/LCX) and somatic mutations in epigenetic regulators (e.g. DNMT3A, TET2, IDH1/2), while differences in CLL are predominantly quantitative (e.g. DNMT3A, TET2). Indeed, and as supported by studies [...]

by Damien Bouvier  and Yves Giguère

Received: 01 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903093

Newborn screening (NBS) for inborn errors of metabolism (IEM) was introduced more than 50 years ago with the testing of phenylketonuria (PKU) using blood spots deposited on a filter paper after heel prick. NBS aims to identify early after birth inherited disorders for which clinical management and pre-symptomatic treatment will significantly decrease morbidity and mortality. While NBS for a few other disorders was implemented in some specific jurisdictions over the following decades, it is with the introduction of [...]

by Christine Pham  , Brett J Pierce  , Simon W Yau  , Jihad Georges Youssef  , Ahmad Goodarzi  and Howard J Huang

Received: 09 July 2021;  Published: 30 August 2021;  doi: 10.21926/obm.transplant.2103152

Data supporting the use of belatacept in non-abdominal organs are limited to case series and small cohorts involving patients requiring conversion due to CNI intolerance or contraindication. Review articles summarizing the efficacy of belatacept salvage therapy in lung transplantation have previously been published, however, dosing regimens are highly variable and uniform guidance is lacking. In this article, indications and considerations for belatacept use in lung transplant recipients are reviewed with a specifi [...]

by Andrea P. Cuevas-Gómez  , Izlia J. Arroyo-Maya  and Humberto Hernández-Sánchez

Received: 26 April 2021;  Published: 22 June 2021;  doi: 10.21926/rpm.2102027

Whey protein is a byproduct of cheese, casein, and Greek yogurt produced in Europe, North America, and Australasia. It is a substantial source of functional proteins and peptides for the worldwide food industry. α-Lactalbumin (α-La) is a globular protein that can be isolated from WPI (whey protein isolates) using techniques such as chromatography/gel filtration, membrane separation, etc. α-La is used in the elaboration of functional foods and is a very good source of peptides with anticancer, antimicrobial, antivir [...]

by Lucy Watts  , Joanna Smith  , Wilfred McSherry  , Michael Tatterton  and Alison Rodriguez

Received: 04 November 2019;  Published: 03 March 2020;  doi: 10.21926/obm.icm.2001012

In palliative and end of life care settings supporting people to make sense of their lives is as important as managing disease symptoms. Dignity Therapy is a validated psychotherapeutic intervention designed to bring about a sense of meaning and purpose for individuals at the end of life. Dignity Therapy has primarily been implemented and evaluated in adult palliative care settings. Prior to designing studies that evaluate Dignity Therapy for children and young people with life-limiting and life-threatening conditi [...]

by Gemechu Fanta Garuma

Received: 29 March 2022;  Published: 06 June 2022;  doi: 10.21926/aeer.2202022

An increase in global temperature will likely result in more intense and frequent heatwaves that would last longer. Simultaneously, the growth of urban population requires more areas of land incorporated into urbanization, because most people are expected to live in cities, which will increase the intensity and duration of urban heat islands. However, the extent of the link between global warming induced heatwaves and urbanization caused heat islands is barely understood. Understanding the link would give a new inf [...]

by Amrin Ahmed  , Alixe Ménard  , Alison C Novak  , Nancy Edwards  and Sarah Fraser

Received: 27 May 2024;  Published: 28 August 2024;  doi: 10.21926/obm.geriatr.2403286

Older adults are disproportionately susceptible to hospitalizations and fatalities due to stair-related falls. While many intrinsic risk factors, such as mobility and vision, may increase the likelihood of falls on stairs, features of the stairs that increase the risk of falls are understudied. This study aimed to capture older adults’ perspectives of stair falls, as well as introduce the Safer Steps app and explore its feasibility in this population. This m-health technology was designed to gather data on st [...]

by Parisa Gazerani  and Brian E Cairns

Received: 26 October 2020;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101082

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. DBS has also been investigated for the treatment of cluster and other primary headaches. Electrodes are surgically implanted into brain structures, for example the posterior hypothalamus in case of cluster headache. Hypot [...]

by Lindy A. Kilik

Received: 30 July 2019;  Published: 29 September 2019;  doi: 10.21926/obm.geriatr.1903076

The current paper introduces the “Priming/Timing/Miming” Model of Behavioural Care Planning for persons with Dementia. This simple heuristic provides a quick, easy and systematic way to select from the vast number of behavioural strategies offered in the BPSD literature and to organize these in a way that can be incorporated into an individualized Behaviour Care Plan to deliver personal care to persons with dementia and also to develop a larger plan of care. An entire care plan is captured on one double-sided sheet [...]

by Jeffery Jonathan Joshua (ישוע) Davis  , Florian Schübeler  and Robert Kozma

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901015

Background: Psychophysiological coherence has been widely studied as a bodily state associated with general well-being and cognitive clarity. Heart Rate Variability (HRV) has been shown to be a good biomarker to assess psychophysiological coherence. This paper presents the first general set of results concerning a study that is part of a team effort between a body of researchers in 5 countries led by the HeartMath Institute under the name, International Heart Rate Variability Synchronization (IHRVS) Study. This stu [...]