by BAGOT Jean-Lionel

Received: 31 May 2018;  Published: 15 September 2018;  doi: 10.21926/obm.icm.1803019

Background: After fatigue, pain is one of the major complaints from cancer patients. Regular use of Class 1 analgesics may cause side effects and is not always sufficient to relieve pain. Homeopathy is the complementary and integrative medicine most frequently used in France in supportive care in oncology (SCO). What is its place in the treatment of pain? Method: Extraction and analysis of results concerning pain from three surveys, two of which were carried out in France, on the main indications of homeopathy in S [...]

by Ute Moog  and Domenico Coviello

Received: 14 August 2018;  Published: 13 September 2018;  doi: 10.21926/obm.genet.1803034

he publication of the double helix DNA structure in 1953 [1] was the kick-off of numerous efforts to understand and unravel the complexity of the human genome. It took 50 years until the human genome project, based on Sanger sequencing, was completed in 2003 [2]. This was followed by what may be considered a revolution in the field of DNA analysis: the introduction of Next Generation Sequencing (NGS) in 2005 consisting of massively parallel sequencing of DNA fragments which allows the high throughput analysis of la [...]

by Dayu Lv  , Jose Garcia-Tirado  and Chiara Fabris

Received: 17 May 2018;  Published: 11 September 2018;  doi: 10.21926/obm.transplant.1803019

Background: Human pancreatic islet transplantation is a minimally-invasive procedure that is gaining recognition for the treatment of type 1 diabetes (T1D). Selected patients with unstable T1D, hypoglycemia unawareness, history of severe hypoglycemia, and glycemic lability, not successfully stabilized with intensive insulin treatment, can be offered this alternative therapy that has been shown to provide long-term glycemic control with near-normalization of hemoglobin A1c in the absence of severe hypoglycemia. Toda [...]

by Amale Laouar

Received: 22 July 2018;  Published: 09 September 2018;  doi: 10.21926/obm.hg.1803010

Gut microbes and pathophysiology of sepsis: Spillage of gut microbial products, rather than systemic dissemination of gut microbes, is the potential initiator of septic morbidity

by Frenny Sheth  , Thomas Liehr  , Kristin Mrasek  , Joris Andrieux  , Stuti Tewari  , Naznin Lubna  and Jayesh Sheth

Received: 23 March 2018;  Published: 07 September 2018;  doi: 10.21926/obm.genet.1803033

Background: Small supernumerary marker chromosomes (sSMC) are rare cytogenetic findings in general, but especially in Turner syndrome so called sSMCT in a karyotype 46, X, +mar are even more scarce. According to the literature, sSMCT are derived from one of the Y-chromosomes in ~70% of the cases. Thus, to identify the presence of Y-chromosomal material is imperative, since these cases have an increased risk of gonadoblastoma deriving from the streak gonads. Methods: A 24-year-old short statured male presented with [...]

by Stamatia Stai

Received: 27 May 2018;  Published: 06 September 2018;  doi: 10.21926/obm.genet.1803032

Immunoglobin A Nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Its development is characterized by the deposition of immune complexes that consist of abnormally galactosylated IgA1 molecules and IgG or IgA autoantibodies in the mesangium and the subsequent induction of renal injury. Recent research has shed light to many aspects of the pathogenesis of the disease, including the contribution of epigenetic modifications in its onset and progression. This review aims to present some of the [...]

by Alexandra Koulouris  , Kathleen Dorado  , Christina McDonnell  , Robert R. Edwards  and Asimina Lazaridou

Received: 27 June 2018;  Published: 05 September 2018;  doi: 10.21926/obm.icm.1803018

Background: This paper presents a review of the evidence regarding the efficacy and impact of Yoga and mindfulness with meditation among patients with rheumatoid arthritis (RA). Patients who suffer from RA express a variety of symptoms that negatively impact their physical functioning and performance in social roles. Yoga and meditation-based therapies have been previously used to manage chronic pain conditions and other persisting disorders in affected populations. The suitability and effectiveness of these practi [...]

by Rene J. Duquesnoy

Received: 11 July 2018;  Published: 05 September 2018;  doi: 10.21926/obm.transplant.1803018

The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes

by Kevin T Ong

Received: 15 May 2018;  Published: 03 September 2018;  doi: 10.21926/obm.geriatr.1803011

Amyloid positron emission tomography (PET), fluorodeoxyglucose (FDG) PET, and magnetic resonance imaging (MRI) are three modalities in the imaging of Alzheimer’s disease (AD). This article reviews the experience and data obtained from AD research using these techniques to understand the natural history of AD and to enhance therapeutic trials. It is now realised that their use can improve early detection of AD, and has opened a new corridor which may lead toward successful treatment.

by Elio Rossi  , Cristina Noberasco  , Marco Picchi  , Mariella Di Stefano  , Linda Nurra  , Antonella Rossi  and Leonardo Ventura

Received: 28 March 2018;  Published: 03 September 2018;  doi: 10.21926/obm.icm.1803017

Background: To manage the adverse effects of anti-cancer treatment, the Homeopathic Clinic of Lucca collaborated with the oncology department of the the Health Unit Toscana North West Lucca and set up an Integrative Oncology Outpatient Unit in the Public Hospital Campo di Marte. Aim: The purpose of this study was to present the results of the homeopathic and complementary integrative medicine treatment targeted at reducing the adverse effects of anti-cancer therapy and cancer symptoms, and to give dietary and lifes [...]