by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Habib Ghaznavi  , Mohammad Hasan Mohammadi  , Ali Reza Modarresi-Alam  , Ali Navidian  , Ali Khajeh  and Mohammad Kazem Momeni

Received: 05 December 2024;  Published: 10 June 2025;  doi: 10.21926/obm.neurobiol.2502289

This study reviews the biochemical mechanisms and clinical implications of N-heterocyclic amine drugs, particularly in the context of pain management, mental health, and opioid withdrawal. It highlights the structural diversity and receptor binding capabilities of these compounds, which enable them to target the nervous system and cross the blood-brain barrier effectively. The article discusses the role of opioids in pain relief, detailing their agonistic effects on opioid receptors and the subsequent risk of addic [...]

by Luis A. Méndez-Rosado  , Luis A. Sotillo-Bent  , José Sotillo-Lindo  , Anduriña Barrios-Martínez  , Dulce Hechavarria-Estenoz  , Margarita Mayeta  , Jose Hernández-Gil  , Hector Pimentel-Benitez  , Maria Elena de la Torre  , Hibo Moreno  , Pedro Díaz-Véliz  , Alicia Vaglio  , Roberto Quadrelli  , Diana Sánchez-Peñarate  , Mabel Cerrillo-Hinojosa  , Pedro Carbonell-de la Torre  , Judith Pupo-Balboa  , Michel Soriano-Torres  , Marilyn del Sol  , Arlay Castelvi  , Enny Morales  , Damarys García  , Rocío Serrano-Hidalgo  , Catalina Obando  , Liz Pardo  , Laritza del Toro  , Miladys Martinez  , Conrado Uria-Gómez  , Maria G Arteaga Ontiveros  , Mayte Castro  , Odalys Rabelo  , Sahily Miñoso  , Deysi Licourt  , Irenia Blanco  , Roberto Lardoeyt-Ferrer  , Nereida Gonzalez  and Olga Quiñones-Masa

Received: 24 November 2024;  Published: 10 June 2025;  doi: 10.21926/obm.genet.2502296

Generally, in reciprocal translocations there are no gains or losses of genetic material. From the clinical point of view, its primary importance lies in the fact that it can generate errors due to incorrect chromosome segregation during meiosis in carriers. On the other hand, other mutations are less frequent in the genome, specifically in the DNA breakpoints implied in these translocations. In Latin America there are no large-scale reports about this topic. To contribute to the study of reciprocal translocations [...]

by Elham Amjad  and Babak Sokouti

Received: 21 February 2025;  Published: 09 June 2025;  doi: 10.21926/obm.transplant.2502251

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as liver biopsies and liver function tests (LFTs), often fail to identify abnormalities early and with accuracy. Genomic RNA sequencing (RNA-Seq) has recently emerged as a powerful approach for identifying molecular markers o [...]

by Ludek Fiala  , Jiri Lenz  and Sarka Papadaki

Received: 28 December 2024;  Published: 06 June 2025;  doi: 10.21926/obm.icm.2502023

This research focused on the evaluation of the relationship between the levonorgestrel-releasing intrauterine device and Hypoactive Sexual Desire Disorder in women. Sexual desire disorder is part of a group of sexual dysfunctions. A group of 60 women with a diagnosis of hypoactive sexual desire were tested in the period from July 2023 to July 2024 at the Institute of Sexology of the 1st Faculty of Medicine in Prague. These patients were examined for levels of prolactin, sex hormone binding globulin, total testoster [...]

by Filomena Emanuela Laddaga  , Bruna Daraia  , Pamela Pinto  , Antonio D’amato  , Stella D’oronzo  , Stefano Martinotti  and Francesco Gaudio

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global acces [...]

by Hawi Jihad Kedir  , Birhanu Zeleke Tilinti  and Kasahun Tsegaye Mekonnen

Received: 07 January 2025;  Published: 02 June 2025;  doi: 10.21926/rpn.2502013

Tomato (Solanum lycopersicum L.) is the largest vegetable crop produced and consumed in the world. Tomatoes are a top source of Vitamin A and C, contain more dietary fibre, beta-carotene, iron, lycopene, magnesium, niacin, potassium, phosphorus, riboflavin, and thiamine. Tomatoes have a limited shelf life in ambient conditions and are highly perishable. It creates glut during the production season and becomes scanty during the off-season. Short shelf life, coupled with inadequate processing facilities results in he [...]

by Ahmad Abdallatif  and Sherif Isaac

Received: 25 November 2024;  Published: 02 June 2025;  doi: 10.21926/obm.geriatr.2502315

Meta-analysist to evaluate impact of Surgical Methods on Outcomes in periprosthetic supracondylar knee fracture management. This study examines the rate of functional outcomes and complications associated with two distinct surgical methods for the management of periprosthetic supracondylar knee fractures in patients treated with Low Contact Locking Plates (LCP) and Retrograde Intramedullary Nails (RIMN). With the growing prevalence of total knee replacements, the incidence of periprosthetic supracondylar knee fract [...]

by Maggi A Budd  and Michelle E Mlinac

Received: 30 January 2025;  Published: 30 May 2025;  doi: 10.21926/obm.geriatr.2502314

Identifying and addressing ethical issues in the care of older adults can be complex and challenging in clinical settings. This article reviews specific ethical principles including autonomy, beneficence, non-maleficence, dignity, and justice, and explores them in the context of interprofessional geriatric care. Situations and related ethical components such as treatment in intensive care units, end-of-life care, dementia care, and aging with advancing technology are included. Case scenarios for each principle or s [...]

by Lucy Keers  , Claudia Lee  , Samara White  and Tammie Lee Demler

Received: 18 February 2025;  Published: 29 May 2025;  doi: 10.21926/obm.geriatr.2502313

Pleural effusions are defined as accumulations of fluid in the pleural cavity surrounding the lungs. They are often secondary outcomes of underlying conditions, such as congestive heart failure, malignancy, or pneumonia. Acute cases of COVID-19 pneumonia have been linked to episodes of pleural effusion, but these cases are often rare. In this report, we analyze a case of pleural effusion in a 71-year-old female patient who had been declining after a recent COVID-19 infection and later died in the hospital. It is no [...]

by Ana Santos  , Elsa Abreu  , Márcia Assunção  , Catarina Simões  and Rita Figueiredo

Received: 31 January 2025;  Published: 28 May 2025;  doi: 10.21926/obm.geriatr.2502312

The growing number of individuals with palliative care needs has led to an increased demand for specialized palliative care teams.. However, these teams often struggle to meet the demand, requiring all nurses to recognize and provide appropriate care during a patient’s last hours and days of life (LHDL). This case report aims to highlight the importance of identifying the LHDL and implementing individualized and adjusted care plans based on the 10/40 model of care. A descriptive-reflective case report following the [...]