by Igor Val Danilov  , Dace Medne  and Sandra Mihailova

Received: 09 February 2025;  Published: 03 July 2025;  doi: 10.21926/obm.neurobiol.2503290

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field an [...]

by Pierre-Yves Maillard  , Sima Tokajian  , Marie Vilaire-Meunier  , Charbel Al Khoury  , Cybel Mehawej  , Eliane Chouery  , Marie-Anne Caillaud  , Louise Maillebouis  , Ines Ben Smida  , Sophie Durand  , Aimé Ravel  , Cecile Cieuta-Walti  , Marie-Noëlle Ungeheuer  , Clotilde Mircher  and André Mégarbané

Received: 05 October 2024;  Published: 03 July 2025;  doi: 10.21926/obm.genet.2503300

To investigate the potential impact of the additional chromosome 21 on the gut microbiome in patients with Down syndrome (DS), two monozygotic (MZ) and two dizygotic (DZ) twin pairs discordant for DS were studied. Whole-genome shotgun sequencing was conducted to analyze the taxonomic and functional profiles of the gut microbial community in the twins and assess whether the gut microbiome composition influences the development of psychological pathologies. Sequencing generated a total of 2,338,132 reads, combined ac [...]

by OBM Geriatrics Editorial Office

Received: 02 July 2025;  Published: 02 July 2025;  doi: 10.21926/obm.geriatr.2503318

by Leandro Goulart de Araujo

Received: 25 June 2025;  Published: 27 June 2025;  doi: 10.21926/cr.2502005

by Sanaz Taherzadeh  , Deanna Gray-Miceli  , Ksenia Zukowsky  , Kathy Gray  and Sarah J. Ratcliffe

Received: 01 February 2025;  Published: 26 June 2025;  doi: 10.21926/obm.geriatr.2502317

Falls are a serious global public health issue affecting individuals of all ages, resulting in serious injuries, fatalities, and extended hospital stays. While knowledge and attitude of healthcare staff toward fall prevention are understood to impact patient safety, less well known are the type and content of fall prevention surveys used to identify nurses’ knowledge of fall prevention. Until now, no study has systematically reviewed the universe of existing tests, surveys, and programs used to assess fall pr [...]

by Jacqueline B. Sperling  , Abigail M. Stark  and Julianne G. Wilner

Received: 27 January 2025;  Published: 26 June 2025;  doi: 10.21926/obm.icm.2502028

School avoidance is associated with a range of negative outcomes and has been increasing in youth in the past several decades. This study examined the efficacy of an intensive outpatient CBT program, for youth (N = 137, ages 8-19) with anxiety disorders or obsessive-compulsive disorder (OCD) and compared both baseline symptoms and outcomes for youth with school avoidance compared to those without. At admission, results indicated that parents of children with school avoidance reported higher levels of family accommo [...]

by Oluwafemi G. Oluwole  , Kili James  and Ambroise Wonkam

Received: 16 January 2025;  Published: 26 June 2025;  doi: 10.21926/obm.genet.2502299

Human mouse orthologous hearing impairment genes were investigated in African patients for causal variants. A homozygous mutation in exon 13 of the microcephalin1 (MCPH1) gene, which encodes the BRCA1-carboxyl terminal 2 domain (BRCT2), was reported in non-syndromic hearing impairment (NSHI). The present study aims to investigate further the emerging roles of MCPH1 in the genetics of NSHI in African patients in the new and larger cohorts. This study screened multiplex families and isolated cases, including 90 patie [...]

by Thomas Liehr  and Peining Li

Received: 20 April 2025;  Published: 26 June 2025;  doi: 10.21926/obm.genet.2502298

Human ring chromosomes (RCs) constitute one of the rarest described inborn chromosomal rearrangements. At first, they seem to be just another subgroup of structural chromosomal aberrations like translocations, inversions, or insertions. However, RCs are more complex, as they almost always occur in conjunction with a mosaic karyotype constitution, resulting in mosaic monosomy of the affected chromosome. Most likely due to the latter effect, a genotype-phenotype correlation is still not available. To proceed with sol [...]

by Chaimae Merimi  , Abdessamad Benabbou  , Lamiae Bourassi  , Abdelhay Addous  , Ahmed A. Elhenawy  , Rachid Touzani  and Belkheir Hammouti

Received: 22 January 2025;  Published: 25 June 2025;  doi: 10.21926/obm.icm.2502027

Cardiovascular diseases and hypertension represent significant global health challenges, driving the need for innovative therapeutic solutions. In this study, we employed advanced in silico methods to investigate the molecular properties of two bioactive compounds, Flavonoids and Rosmarinic Acid, extracted from five medicinal plants: Rosemary, Oregano, Pink Savory, Lemon Balm, and Saffron. The bioactive compounds were evaluated against key biological targets associated with hypertension and cardiovascular diseases, [...]

by Hela Mhiri  , Manel Chalbi  , Nesrine Dridi  , Faten Ouled Brahim  and Med Ali Chemli

Received: 06 April 2025;  Published: 24 June 2025;  doi: 10.21926/obm.genet.2502297

We report the case of a 3-year-old girl from a consanguineous marriage, initially diagnosed with vitamin D deficiency–associated periodontitis following early tooth mobility. Despite supplementation, her condition worsened with the onset of palmoplantar hyperkeratosis. Further investigations revealed the diagnosis of Papillon-Lefèvre Syndrome (PLS), a rare genetic disorder causing severe periodontitis and palmoplantar keratosis. The patient was managed with vitamin D supplementation, dental extractions, and a remov [...]