by David J. Ross  , Abbas Ardehali  , Christine Natori  and John A. Belperio

Received: 19 September 2019;  Published: 07 November 2019;  doi: 10.21926/obm.transplant.1904090

Introduction: TH-17 and IL-6 interactions and detrimental biologic effects have been shown in rodent models of Chronic Lung Allograft Dysfunction (CLAD). Similarly, these pathways have been found to be upregulated in human CLAD. Tocilizumab (TCZ), a humanized monoclonal antibody targets the IL-6 receptor subunit alpha and prevents binding of IL-6. We herein report our preliminary experience with adjunctive TCZ therapy for human CLAD. Methods: We retrospectively reviewed our initial experience with TCZ given after o [...]

by Joseph V. Pergolizzi  , Aaron Tabor  , Jo Ann LeQuang  , Michael Annabi  and Hani Annabi

Received: 05 June 2019;  Published: 05 November 2019;  doi: 10.21926/obm.icm.1904062

Background: The ketogenic diet (KD) was developed in the 1920s as a treatment for pediatric epilepsy and is emerging as a possible treatment option for certain mental health disorders. There is a link between certain mental health disorders and epilepsy, suggesting some commonality among underlying mechanisms. Methods: The literature relating to mental disorders and the KD is sparse. The authors attempt to a narrative review of the existing literature to show that there may be validity to studying the KD as a treat [...]

by Paola Romecín  , Joaquin García-Estañ  and Noemí M. Atucha

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3) Results: We have found several alterations compatible with the existence of a hyperaggregatory state. These alterations are related to a defective platelet calcium handling, spec [...]

by E. Papaconstantinou  , V. Quick  , E. Vogel  and S. Coffey

Received: 09 August 2019;  Published: 31 October 2019;  doi: 10.21926/obm.neurobiol.1904044

Background: Post-secondary students are at increased risk for sleep problems and poor eating behaviours that overtime may lead to negative health outcomes later in life. However, limited research has examined associations of sleep quality with eating behaviours and eating competence (e.g., being positive, flexible, and comfortable with eating and getting enough enjoyable and nutritious foods) among Canadian post-secondary students. Methods: Using a cross-sectional study design, participants completed an online surv [...]

by Susan Kane Patton  , Jennifer Vincenzo  , Holly B. Bennett  , Michelle Gray  , Leah Jean Henry  , Alishia Ferguson  , Ro Dibrezzo  , Christopher S. Walter  and Maryalice Kelly

Received: 15 August 2019;  Published: 29 October 2019;  doi: 10.21926/obm.geriatr.1904084

Aim: The purpose of this study was to evaluate faculty and student perceptions of a fall risk assessment and prevention activity for older adults offered in multiple community settings by health professional faculty and students. Background: In the US, the percentage of adults 65 and older who fell was more than 29% in 2018. Among states, Arkansas ranks 48th with 35.2% of older adults reporting a fall (CDC Behavioral Risk Factor Surveillance System, 2018). Methods: Four senior centers in Northwest Arkansas hosted a [...]

by Taise M. Manhabosco  , Shaul Aloni  , Tevye R. Kuykendall  , Sara M. Manhabosco  , Ana Bárbara Batista  , Jaqueline S. Soares  , Ana Paula M. Barboza  , Alan. B. de Oliveira  , Ronaldo J. C. Batista  and Jeffrey J. Urban

Received: 06 September 2019;  Published: 29 October 2019;  doi: 10.21926/rpm.1904005

Tin telluride (SnTe) ultrathin films were deposited electrochemically on polycrystalline and monocrystalline gold substrates using the electrochemical atomic layer epitaxy (ECALE) method. The electrochemical behaviors of Sn and Te were studied systematically by means of cyclic voltammetry. Cyclic voltammetry curves for Sn displayed a broad peak in the region between -0.15 V and -0.35 V, which was related to the under-potential deposition (UPD), while the curves for Te displayed a peak at 0.3 V for Te UPD. X-ray pho [...]

by Sheri R. Levy  and MaryBeth Apriceno

Received: 20 June 2019;  Published: 28 October 2019;  doi: 10.21926/obm.geriatr.1904083

Worldwide, people are living longer but not necessarily experiencing optimal health since healthy ageing stems from a combination of biological, psychological, and social factors. The growing interdisciplinary literature on ageism from fields such as education, medicine, psychology, and social work increasingly highlights the pivotal role that ageism plays in ageing. Ageism is generally an overlooked factor in understanding and fostering healthy ageing. Ageism creates a negative view of the ageing process as marked [...]

by Priya R. Bhosale  , Oliver H. Wang  and Jeannelyn S. Estrella

Received: 08 July 2019;  Published: 28 October 2019;  doi: 10.21926/obm.hg.1904038

Background: Pure pancreatic-type ACC outside the pancreas is extremely rare. Methods: We presented a very rare case of primary ACC of the pancreatic-type involving jejunum with a synchronous metastasis to left adrenal gland arising in well-developed ectopic pancreas which had fully developed pancreatic acini, islets of Langerhans, ductal structures, pancreatic cancer precursor lesions and a well-formed minor papilla that opens to the mucosal surface of jejunum. We also reviewed all 21 cases of pure pancreatic-type [...]

by Kyungmin Ko  , Juan F. Guerra  and David F. Garvin

Received: 29 August 2019;  Published: 28 October 2019;  doi: 10.21926/obm.transplant.1904089

Background: Graft site candidiasis is a serious complication after solid organ transplantation, often presenting as invasive arteritis leading to graft loss or even death. Case Report: We report a case of anastomotic site candidiasis leading to arterial rupture and death at postoperative day 10 with no clinical warning signs. Preservation fluid cultures were negative and postoperative Doppler ultrasonography did not show vascular compromise. Postmortem examination revealed microscopic arterial wall abscesses harbou [...]

by Elena Crooks  and Kimberly Cleary

Received: 14 September 2019;  Published: 25 October 2019;  doi: 10.21926/obm.geriatr.1904082

Background: Falls are the leading cause of hospitalization and death among older adults; therefore, the ability to predict fall risk among older adults is critical. Several performance-based outcome measures exist to assess fall risk. Psychological factors are also associated with fall risk yet can be difficult to assess and are often overlooked. In this study, we investigated whether the Short Form 36 Item Health Survey (SF-36v2®), a measure of health-related quality of life (HRQOL), predicted future falls in [...]