by Herbert B. Allen

Received: 30 December 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001107

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. This current work will show putative and plausible individual pathways that were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta amyloid; this has been shown in v [...]

by Abdul Al-Toma  and Harry R. Koene

Received: 16 December 2019;  Published: 18 February 2020;  doi: 10.21926/obm.transplant.2001101

Refractory celiac disease (RCD) is a rare condition in which a known celiac patient, usually an adult, suffers from persistence or recurrence of gluten-related symptomatology, laboratory abnormalities, and inflammatory enteropathy despite following an optimal dietary therapy with gluten-free diet (GFD). Arbitrarily, a duration of at least 12 months of GFD has been recommended prior to establishing such a diagnosis. Furthermore, exclusion of the other possible causes of non-celiac villous atrophy, particularly enter [...]

by Sheng-Chieh Lu  , Connie W. Delaney  , Mary Fran Tracy  , Chih-Lin Chi  and Karen A. Monsen

Received: 30 December 2019;  Published: 17 February 2020;  doi: 10.21926/obm.icm.2001006

Integrative health (IH) therapies are increasingly used to manage health conditions, but barriers hindering nurses from offering IH therapies persist. Informatics and artificial intelligence (AI) approaches have potential to promote nurses’ professional use of IH therapies. The purposes of this review are to (1) describe the state of the science of informatics and AI approaches promoting nurses’ use of IH therapies and (2) identify gaps in literature for future investigations. This systematic scoping review followe [...]

by Natalie G. Regier

Received: 04 December 2019;  Published: 17 February 2020;  doi: 10.21926/obm.geriatr.2001106

Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfortunately, these efforts are hindered by inconsistent operational definitions and measurement tools for numerous neuropsychiatric symptoms. This review examines agitation, aggression, restlessness, and rejection of care a [...]

by Marcel Ruiz-Mejias  , Patricia Castano-Prat  , Tony Donegan  and Maria V. Sanchez-Vives

Received: 31 December 2019;  Published: 14 February 2020;  doi: 10.21926/obm.geriatr.2001105

Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) emergent rhythmic activity integrates cellular and network properties of these underlying circuits; and (ii) alterations in rhythmic patterns reflect the functional impact of changes on the network induced by the pathophysiology of the [...]

by Steven R. Potter

Received: 10 February 2020;  Published: 13 February 2020;  doi: 10.21926/obm.transplant.2001100

by Ryosuke Oochi  , Kengo Aoyama  and Akira Ueda

Received: 27 November 2019;  Published: 12 February 2020;  doi: 10.21926/jept.2001002

In order to achieve advancement in zero-emission geothermal power generation for fixing the CO2 in the geothermal fluids to the carbonate minerals after binary power generation and reinjection of the fluid into the reservoir, batch-type experiments and geochemical simulations of CO2-andesitic pyroclastic rock interaction (tuff from Oku-Aizu geothermal area) were performed at 150 °C with and without CO2 gas for 15 days. Despite the low Ca content (0.9% wt.%) in the rock, the Ca2+ concentrations in the solutions [...]

by Rene J. Duquesnoy  and Marilyn Marrari

Received: 13 December 2019;  Published: 10 February 2020;  doi: 10.21926/obm.transplant.2001099

Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus class II eplets shared between HLA-DR, HLA-DQ and/or HLA-DP alleles. This report summarizes current information about antibody-verified interlocus class II eplets. It describes a structural modeling method to determine po [...]

by Morgan J. Minyo  and Katherine S. Judge

Received: 30 July 2019;  Published: 07 February 2020;  doi: 10.21926/obm.geriatr.2001104

Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review considers the illness experience and the need for more research using self-report methodology with persons with dementia in order to address the current gaps within the behaviour literature. With three main objectives, this [...]

by Anupa Pathak  , Saurab Sharma  and Mark P. Jensen

Received: 30 December 2019;  Published: 05 February 2020;  doi: 10.21926/obm.icm.2001005

There is a growing body of research evaluating the effects of hypnosis for the management of clinical pain. A summary of the recent systematic review would help understand the quality of evidence regarding the efficacy of hypnosis, and provide directions for future research. We conducted a scoping review of systematic reviews and meta-analyses on the efficacy of hypnosis for management of clinical pain conditions published after 2013. We searched four databases and two reviewers independently screened studies. We e [...]