by Meir Djaldetti

Received: 10 January 2022;  Published: 14 March 2022;  doi: 10.21926/rpn.2201008

Broccoli has long been reported to exert a positive impact on human health. It contains high levels of isocyanates, the most important of which is sulforaphane (SFN). Numerous studies have demonstrated that SFN can be used as an effective supplement for treating a variety of diseases. In addition, it is known to possess anti-cancer properties such as chemopreventive properties against gastrointestinal, breast, lung, bladder, prostate, and other cancers. The reported data indicates that broccoli could be a potent in [...]

by Haruka Sawamura  , Kurumi Taniguchi  , Yuka Ikeda  , Ai Tsuji  , Yasuko Kitagishi  and Satoru Matsuda

Received: 16 November 2021;  Published: 08 March 2022;  doi: 10.21926/rpn.2201007

Immune checkpoints have been aggressively investigated for anti-cancer immunotherapy. The power of microbiota on the outcome of this immunotherapy has attracted much attention. For example, intestinal microorganisms play a key role in the effectiveness of programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4) blockade. Additionally, short-chain fatty acids produced in the gut may modulate anti-CTLA4 and anti-PD1 stimulated immune responses and their anti-tumor efficacy. Enhancing the [...]

by Suman Mishra  , Kerry Bentley-Hewitt  , Alex Lubransky  , Bernard Venn  , Duncan Hedderley  , Hannah Dinnan  , Sheridan Martell  , Jillian Haszard  and John Monro

Received: 22 December 2021;  Published: 25 February 2022;  doi: 10.21926/rpn.2201006

People with pre-diabetes may be reluctant to add fruit to their diets due to concerns around sugars. Our objective was to measure outcomes associated with potential adverse effects of ingesting fruit sugars while assessing metabolic benefits from eating nutrient-rich kiwifruit. Thirty-four people with pre-diabetes were randomized to receive two kiwifruit or 250 mL bottled water per day for 12-weeks; two people withdrew. The primary outcomes were between-group differences for glycated haemoglobin (HbA1c) and plasma [...]

by Kathy Carter  , John Campbell  , Peyton Shoemaker  , Elisabeth Dichiara  , Neel Patel  and John Caruso

Received: 09 December 2021;  Published: 23 February 2022;  doi: 10.21926/rpn.2201005

Space flight imposes a myriad of adverse effects upon the human body. Improved in-flight nutritional strategies help mitigate those adverse effects. This review examines how space flight changes human physiology, and how improved in-flight nutritional strategies may address the unique dietary needs created by microgravity exposure. Dietary approaches and recommendations to address those needs are discussed. This review also describes food sustainability methods for long-term manned space flight, how precision nutri [...]

by Clemens Drenowatz  , Gerson Ferrari  , Gerhard Ruedl  , Armando Cocca  and Klaus Greier

Received: 15 November 2021;  Published: 18 February 2022;  doi: 10.21926/rpn.2201004

Poor lifestyle choices in adolescents, including low physical activity (PA), excess screen time, and unhealthy dietary habits, are major threats to their health in the future. Unhealthy behaviors such as insufficient PA, high TV time, and poor dietary choices also tend to cluster, but information on the combined association of screen time, sports participation, and dietary habits is limited in Austrian youth. To examine the association among these behaviors, 165 adolescents (74 girls and 91 boys) between 11 and 14 [...]

by Dana Shamshtein  and Timur Liwinski

Received: 06 December 2021;  Published: 17 February 2022;  doi: 10.21926/rpn.2201003

Major depressive disorder (MDD) is a debilitating illness that places a great burden on global health. A ketogenic diet, which has traditionally been used for treating refractory epileptic disorders, is being increasingly explored for its potential of alleviating other neuropsychiatric conditions. Providing an up-to-date summary on the ketogenic diet’s potential to alleviate MDD, its neurobiological basis, and preliminary clinical evidence. A structured literature survey was performed, and a narrative review was wr [...]

by Phil Ayers  , Megan Harlow  and LeAnn Scott

Received: 30 December 2021;  Published: 15 February 2022;  doi: 10.21926/rpn.2201002

Parenteral nutrition (PN) is a complex medication administered to adult, pediatric, and neonatal patients. PN is recognized as a high-alert medication by the Institute for Safe Medication Practices (ISMP). The American Society for Parenteral and Enteral Nutrition (ASPEN) has published several key recommendations regarding safe use of PN. This manuscript will review several of the important PN papers published in 2020-2021 by ASPEN.

by Alicia Stapp  , Madalyn Falkenheiner  and Kenya Wolff

Received: 15 November 2021;  Published: 13 January 2022;  doi: 10.21926/rpn.2201001

It is recommended that children ages 3-5 receive 180 minutes of physical activity a day, with at least 60 minutes of moderate-to-vigorous physical activity. Despite these recommendations, a majority of preschoolers are not provided opportunities in the early childhood education setting to meet these daily recommendations through either structured or unstructured physical activity. Accordingly, the number of young children identified as overweight or obese over the past couple of decades has increased. Critical to a [...]

by Madalina Neacsu  , Susan E. Anderson  , Pola Verschoor  , Nicholas J. Vaughan  , Graham W. Horgan  , Toine Hulshof  , Sylvia H. Duncan  , Susan Duthie  and Wendy R. Russell

Received: 08 October 2021;  Published: 17 December 2021;  doi: 10.21926/rpn.2104002

Wheat bran cereals are an important source of dietary fibre. The aim of the study was to investigate if a high intake (120 g) of fibre rich breakfast cereal (which delivers the UK Government guidelines for fibre intake in one serving but is three-fold higher than the manufacturers recommended serving) has additional potential health benefits compared to the recommended serving (40 g, containing 11 g of dietary fibre). To assess this, the study determined the short chain fatty acid (SCFA) profiles in human faecal, u [...]

by Alex T. Von Schulze  , Marie van der Merwe  , Chad D. Touchberry  and Richard J. Bloomer

Received: 03 August 2021;  Published: 15 October 2021;  doi: 10.21926/rpn.2104001

Poor dietary habits can lead to obesity and insulin resistance—both of which can impair basal heat shock protein (HSP) expression and the HSP stress response in skeletal muscle. It remains unclear if impairments in HSP expression occur during the early stages of diet-induced obesity and metabolic dysfunction. We determined if basal HSP expression (HSP70, HSP60, HSP25) was impaired in sedentary or exercised rats following the onset of diet-induced obesity. Male Long-Evans rats (N=6-7/group) were assigned to a [...]