by Yulia Aleksandrova  , Alexey Semakov  , Dmitry Tsypyshev  , Kirill Chaprov  , Sergey Klochkov  and Margarita Neganova

Received: 23 August 2023;  Published: 09 January 2024;  doi: 10.21926/obm.neurobiol.2401207

Here, we report the results of an investigation of the neuroprotective effects of securinine with tryptamine conjugate-allomargaritarine (2b), previously selected as the leading compound among a wide range of natural derivatives. 2b was synthesized from securinine using various Lewis acids as catalysts. In addition to the antioxidant and cytoprotective properties previously shown for 2b, in this work, in vitro analysis of the biological activity of the compound demonstrated that this conjugate is also able to influ [...]

by Talha Nazir  , Muhammad Umair  , Muhammad Mushhood Ur Rehman  , Reeda Saeed  , Osama O Zaidat  and Junaid S. Kalia

Received: 02 June 2023;  Published: 09 January 2024;  doi: 10.21926/obm.neurobiol.2401206

According to 2019 WHO data, neurological conditions contribute to 1503.39 disability-adjusted life years (DALYs) per 100,000 population. Approximately 57% of office-based physicians use EHR systems and the natural place to incorporate standardized ePRO is into EHR. However, implementing patient-reported outcomes (PROs) for neurological conditions is challenging because many patients are elderly, have comorbidities, and experience cognitive impairment. As healthcare digitization increases, we propose a framework for [...]

by Nadia A. Abdelmegeed Abdelwahed

Received: 19 September 2023;  Published: 04 January 2024;  doi: 10.21926/obm.neurobiol.2401205

Entrepreneurial intention plays a pivotal role within entrepreneurship ecosystems, acting as a catalyst for economic growth and innovation by inspiring individuals to embrace entrepreneurship as a viable career pursuit. The present research delves into the intricate dynamics between stress, entrepreneurial intention, personal income, and physical health within Egypt's entrepreneurial landscape. Grounded in a quantitative analysis of 286 valid samples and utilizing SmartPLS 4, this study unveils compelling insights. [...]

by OBM Neurobiology Editorial Office

Received: 03 January 2024;  Published: 02 January 2024;  doi: 10.21926/obm.neurobiol.2401204

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal’s editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the [...]

by Giulio E. Lancioni  , Gloria Alberti  , Chiara Filippini  , Alessandra Fiore  , Clarissa Simonetti  , Nirbhay N. Singh  , Mark F. O'Reilly  and Jeff Sigafoos

Received: 09 October 2023;  Published: 02 January 2024;  doi: 10.21926/obm.neurobiol.2401203

This study adapted a new interactive technology system to help six participants with intellectual disability and visual and motor impairments to exercise relevant physical responses as part of an occupational task. The task was to place objects into different containers from a sitting position. The responses, which changed across sessions, consisted of the participants (a) stretching the left arm and shoulder to place objects in a container located to their left, (b) stretching the right arm and shoulder to place o [...]

by Giulio E. Lancioni  , Nirbhay N. Singh  , Mark F. O'Reilly  , Jeff Sigafoos  , Gloria Alberti  and Marta Olivetti Belardinelli

Received: 09 September 2023;  Published: 15 December 2023;  doi: 10.21926/obm.neurobiol.2304202

The paper presents an overview of recent studies assessing technology-aided strategies aimed at helping people with intellectual and multiple disabilities reach relevant rehabilitation goals. The 16 studies included in the paper addressed four specific rehabilitation goals, that is, (a) performance of functional activities, (b) access to leisure and communication and performance of functional activities, (c) increase of adaptive responses and decrease of problem behavior or inadequate posture, and (d) increase of a [...]

by Gil Newburn  , Joshua P McGeown  , Eryn E Kwon  , Maryam Tayebi  , Paul Condron  , Taylor Emsden  , Samantha J Holdsworth  , Daniel M Cornfeld  and Graeme M Bydder

Received: 30 June 2023;  Published: 14 December 2023;  doi: 10.21926/obm.neurobiol.2304201

In modelling studies targeted MRI (tMRI) of small increases in the T1 of tissues using divided Subtracted Inversion Recovery (dSIR) sequences show ten or more times the contrast seen with conventional IR sequences. This may be particularly useful in imaging normal appearing white matter where there may be small changes in T1 and/or T2 in disease but these changes may be insufficient to produce useful contrast with conventional T2-weighted spin echo (T2-wSE) and T2-FLuid Attenuated Inversion Recovery (T2-FLAIR) sequ [...]

by Axel Becker  , Martin Helmuth  and Ben A. Chindo

Received: 19 October 2023;  Published: 05 December 2023;  doi: 10.21926/obm.neurobiol.2304200

A stroke is a cerebrovascular disease that results from a blockage in the blood supply to part of the brain or a burst blood vessel in the brain. It is the second leading cause of death worldwide, with an annual mortality rate of about 5.5 million. Antithrombotic therapies have failed to provide a cure for this debilitating cerebrovascular disorder, and hypothermia is gaining interest as a novel strategy for the management of stroke. In this study, we evaluated the effects of Ficus platyphylla-induced hypothermia o [...]

by Linh Nguyen Thi Phuong  , Khoa Le Duc  , Khanh Do nam  , Hao Tran Thi  , Huong Dang Thi  , Giang Le Minh  and Van Hoang Thi Hai

Received: 11 October 2023;  Published: 30 November 2023;  doi: 10.21926/obm.neurobiol.2304199

The COVID-19 pandemic has placed a considerable burden on frontline healthcare workers (HCWs), thus increasing their vulnerability to developing posttraumatic stress disorder (PTSD). Our study aimed to examine the relationship between possible PTSD symptoms and resilience and identify associated factors with possible PTSD symptoms among Vietnamese frontline HCWs during the COVID-19 pandemic in 2021. We conducted a cross-sectional study across medical facilities at three administrative levels: provincial, district, [...]

by Krishanu Aich  , Sukrit Kashyap  , Konika Tyagi  , Ishika Verma  , Abhimanyu Chauhan  and Chakresh Kumar Jain

Received: 09 April 2022;  Published: 29 November 2023;  doi: 10.21926/obm.neurobiol.2304198

Today, the advancement of assessment, forecasting, and therapy or medical attention for psychological healthcare is already using artificial intelligence (AI) technology, particularly machine learning, due to the introduction of digital tools to treat mental health conditions. In mental health treatment, the present and the future of artificial intelligence technologies hold both enormous promises and potential dangers. With the current global scenario, psychological disorders like clinical depression, general anxi [...]