by Elisa Bertulla  , Ilaria Baldelli  , Andrea Antonini  and Edoardo Raposio

Received: 14 November 2025;  Published: 28 February 2026;  doi: 10.21926/obm.neurobiol.2601327

Migraine surgery is primarily indicated for patients with chronic migraine who are refractory to conventional pharmacological treatments. The procedure aims to deactivate peripheral trigger sites—anatomical zones where migraines can be triggered by nerve compression and irritation. The most common trigger areas are the frontal, occipital, and temporal. This review seeks to analyse the prevalence of treatment and corresponding success rates for these three main trigger sites. A systematic review was conducted on Pub [...]

by Nadezhda D Broshevitskaya  , Anastasia A Rebik  , Lidia M Birioukova  , Maria I. Zaichenko  and Inna S Midzyanovskaya

Received: 28 September 2025;  Published: 25 February 2026;  doi: 10.21926/obm.neurobiol.2601326

The inbred Krushinsky-Molodkina (KM) rat strain, characterized by latent genetic epilepsy, reduced social motivation, and a high propensity for freezing, is a promising model for translational research of social deficits in autism spectrum disorder (ASD). In clinical practice, social deficits often lead to social withdrawal and can be accompanied by aggression. It was unknown if KM rats exhibit such aggression during inescapable social encounters. We assessed intraspecific aggression in KM and control rats using th [...]

by Alireza Ala  , Samad Shams Vahdati  , Eliyar Sadeghi-Hokmabadi  , Sadaf Jalilzadeh  , Mahsa Kashtkar  and Asghar Jafari Rouhi

Received: 22 February 2025;  Published: 25 February 2026;  doi: 10.21926/obm.neurobiol.2601325

The "Sama Code" is a protocol implemented in Iranian pre-hospital emergency services to manage time and treat patients with suspected stroke symptoms based on the FAST criteria. This study aims to analyze the workflow of patients with stroke symptoms transferred under the Sama Code. All patients with neurological symptoms who were brought to Imam Reza Hospital by pre-hospital emergency services after activating the Sama Code during the years 2021 and 2022 were included in the study. Data were collected from pre-hos [...]

by Mona-Elisa Eberharter

Received: 03 November 2025;  Published: 12 February 2026;  doi: 10.21926/obm.neurobiol.2601324

Using a two-stage qualitative design (Stage 1: expert interviews; Stage 2: biographical interviews with people with MS), existing governmental and organizational support measures for maintaining the work capacity of individuals with multiple sclerosis (MS) were analyzed, and proposals for improvement were developed. Additional state support measures were proposed, including relaxing the criteria for state assistance, creating a centralized contact point for MS-specific inquiries, and enhancing collaboration between [...]

by Fabrizio Stasolla  , Enza Curcio  , Antonio Zullo  , Mariacarla Di Gioia  and Anna Passaro

Received: 04 November 2025;  Published: 10 February 2026;  doi: 10.21926/obm.neurobiol.2601323

Mathematical learning often presents persistent challenges for children and adolescents with Autism Spectrum Disorder (ASD) due to differences in Executive Functioning (EF), cognitive flexibility, and symbolic reasoning. These factors can hinder the development of numerical understanding and pre-mathematical reasoning, problem-solving, and abstract thinking, frequently resulting in disengagement and anxiety. In recent years, digital and embodied technologies—particularly Serious Games (SG) and Educational Robotics [...]

by Mojtaba Ehsanifar  , Akram Gholami  , Nioosha Pahnavar  , Reyhaneh Shenasi  and Maryam Golmohammadi

Received: 27 October 2025;  Published: 09 February 2026;  doi: 10.21926/obm.neurobiol.2601322

Mycotoxins, toxic secondary metabolites produced by fungi and molds, have negative health impacts on both humans and animals. They are commonly found in foods such as nuts, coffee, cereals, and grains, particularly in regions with warm, humid climates. Among the most prevalent mycotoxins in these foods are aflatoxin B1, ochratoxin A, zearalenone, patulin, and deoxynivalenol (DON). The presence of mold capable of producing mycotoxins within food contributes to an elevated risk of various illnesses, including those r [...]

by Walter Paganin

Received: 30 July 2025;  Published: 27 January 2026;  doi: 10.21926/obm.neurobiol.2601321

Difficult-to-treat depression (DTD) with inflammatory features (e.g., hs-CRP ≥3 mg/L and/or elevated IL-6) may represent a clinically and biologically distinct presentation characterized by chronicity, functional impairment, prominent cognitive-motivational symptoms, and suboptimal response to conventional treatments. Classical anti-inflammatory strategies (e.g., COX-2 inhibitors or cytokine-targeting biologics) have shown signals of efficacy in selected biomarker-enriched subgroups; however, overall evidence remai [...]

by Mohsen Khosravi

Received: 19 September 2025;  Published: 26 January 2026;  doi: 10.21926/obm.neurobiol.2601320

Personalized psychopharmacotherapy remains a critical yet underdeveloped frontier in psychiatry, as traditional approaches often fail to address substantial interindividual variability in drug efficacy and tolerability. While demographic, clinical, and genetic factors have improved treatment precision, they do not fully account for observed heterogeneity. Recent advances highlight the promise of personality traits, particularly as operationalized by Cloninger’s Seven-Factor Model, as novel biomarkers for treatment [...]

by Ioannis Syros  , Anna Tsourdini  , Blossom Fernandes  and Xenia Anastassiou-Hadjicharalambous

Received: 23 September 2025;  Published: 22 January 2026;  doi: 10.21926/obm.neurobiol.2601319

Super Skills for Life (SSL) is a transdiagnostic psychoeducational program designed for children with anxiety and depressive symptoms based on cognitive-behavioral therapy. Empirically documented studies to date have demonstrated its immediate and long-term effectiveness in different contexts. The aim of this study was to assess the efficacy of the SSL program to reduce emotional and behavioral difficulties in a clinical sample of Greek-speaking primary school children aged 6 to 12. The program was implemented over [...]

by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Ali Reza Modarresi-Alam  and Mohammad Hasan Mohammadi

Received: 03 May 2025;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601318

The study explores the crucial biological function of nitrogen in cyclic and acyclic structures with resonance potential, including tetrazoles, pyrroles, piperidines, and carbamates, within the realm of chemical neuroscience. It highlights the importance of these compounds for their biological properties and their ability to cross the blood-brain barrier (BBB) to reach the central nervous system (CNS). The study emphasizes the necessity for neurochemical drugs, like morphine, to effectively cross the BBB, as modifi [...]