by Srinivasan Periasamy  , Se-Ping Chien  , Chen Hsu  , Dur-Zong Hsu  and Ming-Yie Liu

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047

Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hyperglycemia and diabetes. We studied the role of metformin in reversing sleep deprivation-induced hyperglycemia and pancreatic and liver dysfunction in mice. Mice were kept in cages and fed water and food ad libitum. Mice wer [...]

by Haris Muhammad  , Muhammad Hammami  , Peng-sheng Ting  , Cem Simsek  , Behnam Saberi  and Ahmet Gurakar

Received: 02 February 2020;  Published: 24 April 2020;  doi: 10.21926/obm.hg.2002046

Liver transplantation has steadily increased worldwide resulting in a large number of patients on the waiting list. Due to the opioid epidemic in the US, the pool of Hepatitis C seropositive donors increased significantly in recent years. Direct acting antivirals played an instrumental role in making liver transplantation with hepatitis C positive allograft an acceptable option. Although hepatitis C positive liver transplantation to hepatitis C positive recipients is a common practice, there is limited data and agr [...]

by Jean-François Cadranel  and Jean-Baptiste Nousbaum

Received: 21 August 2019;  Published: 15 April 2020;  doi: 10.21926/obm.hg.2002045

The literature on the prevalence of spontaneous bacterial peritonitis (SBP) in cirrhotic outpatients who visited the hospital for therapeutic abdominal paracentesis was reviewed in order to assess the usefulness of urinary strips in this setting. The authors reviewed the studies published as peer-reviewed articles on the prevalence of SBP in ambulatory outpatients who visited the hospital for therapeutic paracentesis. Five such studies were available in the literature. It was found that the prevalence of SBP was in [...]

by Hsuan-Wei Chen  , Hsuan-Hwai Lin  , Yu-Lueng Shih  , Tsai-Yuan Hsieh  and Jung-Chun Lin

Received: 23 February 2020;  Published: 30 March 2020;  doi: 10.21926/obm.hg.2001044

by Tommy Sundqvist  , Lars Stenhammar  , Bo Tjellström  , Karl-Eric Magnusson  , Tore Midtvedt  , Elisabeth Norin  and Lotta Högberg

Received: 07 February 2020;  Published: 09 March 2020;  doi: 10.21926/obm.hg.2001043

by Pier Alberto Testoni  and Sabrina Testoni

Received: 17 October 2019;  Published: 23 December 2019;  doi: 10.21926/obm.hg.1904042

Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found either on the occasion of the first episode of pancreatitis or during the follow-up. The etiology of RAP can be identified in up to 70% of cases; for the remaining cases the term “idiopathic” is used. Most common caus [...]

by Ken Sato  , Atsushi Naganuma  , Shuichi Saito  , Yuichi Yamazaki  , Takeshi Kobayashi  , Hiroki Tojima  , Norio Horiguchi  , Satoru Kakizaki  , Toshio Uraoka  , Hiroshi Ohnishi  and Hiroaki Okamoto

Received: 29 September 2019;  Published: 17 December 2019;  doi: 10.21926/obm.hg.1904041

Background: Daclatasvir/asunaprevir/beclabuvir (DCV/ASV/BCV) combination therapy had been available for the treatment of chronic hepatitis C patients with genotype 1 (CHG1) in Japan. Our aim was to report the efficacy and safety of DCV/ASV/BCV in patients experiencing treatment failure with interferon (IFN)-free direct-acting antiviral agent (DAA)-based therapies, which have not been fully evaluated. Methods: We evaluated the efficacy and safety of 12-week DCV/ASV/BCV combination therapy for CHG1 patients experien [...]

by Mauro Turrin  , Barbara Mariotti  , Isabella Schiavon  and Serena Battista

Received: 29 September 2019;  Published: 22 November 2019;  doi: 10.21926/obm.hg.1904040

Hypereosinophilic syndrome is currently defined by an absolute blood eosinophil count of more of 1500 cell per μL for more than 1 month and by multiorgan system infiltration. Eosinophilic colitis is an exceptionally rare inflammatory condition in which eosinophils infiltrate the colonic gut. It represents the least frequent manifestation of the wide spectrum of eosinophilic gastrointestinal disorders. We describe a case of an adult male patient with persistent eosinophilia for at least twenty-five years. During thi [...]

by Paola Romecín  , Joaquin García-Estañ  and Noemí M. Atucha

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3) Results: We have found several alterations compatible with the existence of a hyperaggregatory state. These alterations are related to a defective platelet calcium handling, spec [...]

by Priya R. Bhosale  , Oliver H. Wang  and Jeannelyn S. Estrella

Received: 08 July 2019;  Published: 28 October 2019;  doi: 10.21926/obm.hg.1904038

Background: Pure pancreatic-type ACC outside the pancreas is extremely rare. Methods: We presented a very rare case of primary ACC of the pancreatic-type involving jejunum with a synchronous metastasis to left adrenal gland arising in well-developed ectopic pancreas which had fully developed pancreatic acini, islets of Langerhans, ductal structures, pancreatic cancer precursor lesions and a well-formed minor papilla that opens to the mucosal surface of jejunum. We also reviewed all 21 cases of pure pancreatic-type [...]