Table of Contents

Open Access

ISSN 2577-5820

OBM Transplantation , Volume 4 , Issue 4 (2020)

Pages: 124

Published: January 2021

(This book is a printed edition that was published in OBM Transplantation)

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Cover story:We performed a retrospective study of allogeneic HSCT for severe aplastic anaemia. Sibling and MUD outcomes were similar, however patients aged >40 years had inferior survival due to high incidence of acute kidney injury requiring modification of GVHD prophylaxis. Further research is required to optimise HSCT conditioning and GVHD prophylaxis protocols in older patients. View this paper.

Volume 4,Issue 4

Open Access Review

The Role of Surveillance Bronchoscopy Following a Lung Transplantation

Received: 01 July 2020;  Published: 21 December 2020;  doi: 10.21926/obm.transplant.2004129


Pulmonary transplantation (LuTx) is established as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, and pulmonary arterial hypertension. Acute rejection and infection are implicated as potential risk factors in developing complications such as bronchiolitis obliterans syndrome (BOS) and chronic rejection, leading to high morbidity and mortality rates after the LuTx. Thus, surveilla [...]

Open Access Case Report

Donor Cell-Derived Acute Myeloid Leukaemia with 3q26.2 Involvement/MECOM Rearrangement ‐ A Case Report and Literature Review

Received: 13 October 2020;  Published: 07 December 2020;  doi: 10.21926/obm.transplant.2004128


Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). DCL might represent up to 5% of the post-HSCT disease relapses, but case numbers reported in the literature might underestimate the frequency. The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. Although many theories have been proposed for leukemogenesi [...]

Open Access Review

The Roles of Collagen in Islet Transplantation

Received: 02 October 2020;  Published: 27 November 2020;  doi: 10.21926/obm.transplant.2004127


Islet transplantation is a cellular replacement therapy for severe diabetes mellitus. Although the clinical outcome of islet transplant has been improving, the transplant efficacy of this treatment is not superior to that of pancreatic organ transplantation, a similar transplant therapy. Various factors have been characterized as ‘islet transplantation specific’, which includes lack of revascularization and ischemia, innate inflammation, or autoimmunity, affect the therapeutic outcome of this tr [...]

Open Access Editorial

Challenges of Organ Transplantation in COVID-19 Era

Received: 01 November 2020;  Published: 19 November 2020;  doi: 10.21926/obm.transplant.2004126

Open Access Review

Current Assessment of Clinical Pancreatic Islet Allotransplantation

Received: 20 September 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004125


Clinical islet allotransplantation represents a minimally invasive, efficacious alternative to pancreas transplantation for restoring glycemic control and insulin independence in select patients with type 1 diabetes that is complicated by intractable impaired hypoglycemia awareness and/or severe hypoglycemic events refractory to stabilization by other means. Over the last decade, islet transplantation outcomes have steadily improved in part due to refinements in the selection of optimal donors, [...]

Open Access Review

Mauss and Organ Transplants: Ideas of Connectivity between Recipients and Donors and the “Spirit of the Gift”

Received: 22 July 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004124


This article aims to describe the relationship between donors and their recipients in the context of organ transplants. This analysis is made in the light of Marcel Mauss’s work, offering an expansion on an analysis of his discussion on the “spirit of the gift” and his idea that gifts require reciprocation. It is argued that some recipients of donated organs receive a personal element from the donor in that there is a transfer or sharing of the donors’ personality and spiritual qualities. The ar [...]

Open Access Case Report

Liver Transplantation as a Cure for Neurologically Advanced Wilson’s disease. Learning More from Experience

Received: 05 July 2020;  Published: 12 November 2020;  doi: 10.21926/obm.transplant.2004123


Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson’s disease is based on the combination of specific clinical findings, laboratory and genetic testing. There are different modalities of treatment available for [...]

Open Access Communication

Appropriate Vancomycin Use and Incidence of Vancomycin-Resistant Enterococci in Liver Transplant Recipients

Received: 24 July 2020;  Published: 09 November 2020;  doi: 10.21926/obm.transplant.2004122


Liver transplant recipients (LTRs) are at risk for vancomycin-resistant Enterococcus (VRE) infections which can lead to significant morbidity or mortality. Antibiotic exposure, including vancomycin, is associated with greater risk of VRE infection. This study aimed to assess the appropriateness of vancomycin use and rates of VRE infection in this population. We performed a retrospective cohort study of 327 patients who underwent liver transplantation at our center from January 1, 2012 to June 30 [...]

Open Access Original Research

“Real World” Australian Experience of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Adults with Severe Aplastic Anaemia.

Received: 23 June 2020;  Published: 23 October 2020;  doi: 10.21926/obm.transplant.2004121


Acquired Severe Aplastic Anaemia (SAA) is a rare bone marrow failure syndrome, for which allogeneic haematopoietic stem cell transplant (HSCT) is a proven curative therapy. Despite excellent outcomes for matched sibling SAA recipients in terms of engraftment and survival, HSCT remains highly challenging in older matched-unrelated-donor (MUD) recipients, due to increased non-relapse mortality (NRM) from causes such as graft versus host disease (GVHD), organ failure and infection. We sought to eva [...]

Open Access Case Report

Donor Derived Strongyloidiasis in a Lung Transplant Recipient: From Life Cycle to Hyperinfection Syndrome

Received: 04 September 2020;  Published: 13 October 2020;  doi: 10.21926/obm.transplant.2004120


Strongyloides stercoralis infection derived from the donor in solid organ transplant (SOT) places recipients at risk for hyperinfection syndrome and death. We describe the case of a lung transplant recipient who developed strongyloidiasis presenting with GI symptoms and progressing to diffuse alveolar hemorrhage, bacteremia and multi-organ failure. The patient’s clinical course illustrates the life cycle of Strongyloides. For treatment, the patient received ivermectin and albendazole. We advocat [...]