Illuminate Resection Pathways with Fluorescence Guidance in Glioma Surgery: Case Reports and Systematic Review
Abstract
(ISSN 2573-4407)
OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
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Special Issue
Novel Approaches to Glioblastoma
Submission Deadline: November 30, 2020 (Open) Submit Now
Guest Editor
Divya Mella, MD
Attending Neuro-Oncologist, Baylor Scott and White, Dallas, TX-USA
Research Interests: Neuro-Oncology; Brain Tumors; Neuropathology; Neuroimaging
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Publication
Illuminate Resection Pathways with Fluorescence Guidance in Glioma Surgery: Case Reports and Systematic Reviewby
Manuel De Jesus Encarnacion Ramirez
,
Nikolay Konovalov
,
Stanislav Kaprovoy
,
Gennady Chmutin
,
Geovany Venegas Cerna
,
Renat Nurmukhametov
,
Andreina Rosario Rosario
,
Kalin Ivan Yakovlevich
,
Jesus Lafuente
,
Eric Suero Molina
and
Nicola Montemurro
Abstract Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucia [...] |
Minimally Invasive Treatments for Glioblastoma: A Review of Current and Emerging Surgical TechnologiesAbstract Glioblastoma (GBM) is malignant, primary intracranial neoplasm associated with poor outcomes. Maximal, safe cytoreduction remains an important component of effective treatment for patients with this disease; however, some patients are not candidates for resection due to comorbid status, tumor location, or other factors. In this review, we [...] |
Examining the Role of Specialized DNA Polymerases in the Development of Temozolomide Resistance in Glioblastoma MultiformeAbstract Glioblastoma multiforme (GBM) is an extremely malignant type of primary brain tumor that exhibits a high mortality rate. Current standard therapy involves surgery followed by radiation and treatment with the DNA-alkylating agent, temozolomide (TMZ). While TMZ treatment can extend post-operative survival, most patients develop resis [...] |
Light-Activated Local Drug Delivery From Hydrogels: Potential for GBM Treatmentby
Lina Nguyen
,
Gabrielle Romena
,
Ethan Nguyen
,
Cassandra Tran
,
Kaitlyn Nguyen
,
Ananya Devarajan
and
Henry Hirschberg
Abstract Following post-operative treatment, the vast majority of GBMs recur, usually within 2 cm of the tumor resection margin. Since these tumors seldom metastasize outside the CNS, improved localized therapies should prove beneficial. Drug delivery systems (DDS) that allow control over drug release by an externally applied energy, such as light [...] |
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