Table of Contents

Open Access

ISSN 2573-4407

OBM Neurobiology , Volume 5 , Issue 4 (2021)

Pages: 115

Published: April 2022

(This book is a printed edition that was published in OBM Neurobiology )

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Format: Soft Cover


Cover story:The COVID-19 pandemic has negatively impacted the psychological wellbeing of many people, and older adults are particularly vulnerable to these consequences. The current paper reviews data on past pandemics to estimate possible long-term effects of the COVID-19 pandemic on depression and suicide risk in older adults. View this paper.

Volume 5,Issue 4

Open Access Communication

Neuronal Coherence Agent for Shared Intentionality: A Hypothesis of Neurobiological Processes Occurring during Social Interaction

Received: 02 October 2021;  Published: 29 December 2021;  doi: 10.21926/obm.neurobiol.2104113


The present interdisciplinary study discusses the physical foundations of the neurobiological processes occurring during social interaction. The review of the literature establishes the difference between Intentionality and Intention, thereby proposing the theoretical basis of Shared Intentionality in humans. According to the present study, Shared Intentionality

Open Access Review

The Potential Impact of COVID-19 on Depression and Suicide Risk in Older Adults

Received: 19 January 2021;  Published: 24 December 2021;  doi: 10.21926/obm.neurobiol.2104112


COVID-19 infections, hospitalizations, and deaths continue to skyrocket across the world, leaving a trail of enduring psychological turmoil. It wreaks havoc on the physical, emotional, and cognitive health of those directly infected, as well as caretakers, friends, and families. Though the pandemic has at least indirectly impacted most people, older adults appear to be the most vulnerable to COVID-19-related deaths and little is known about the psychological consequences. Unfortunate [...]

Open Access Review

Effects of Circadian Rhythm on Migraine Therapy

Received: 24 June 2021;  Published: 20 December 2021;  doi: 10.21926/obm.neurobiol.2104111


Circadian rhythms are 24-hour cycles of physical, mental, and behavioral changes regulated and maintained by the internal primary circadian clock, however modifiable by a number of external cues or “zeitgebers”, the most powerful one being light. Core set of clock genes regulate the whole-body metabolism and transcription of over 40% of mammalian RNA, including that for drug transporters, binding and metabolizing proteins responsible for regulation of pharmacokinetics of vast array o [...]

Open Access Original Research

The Relationship between Sensory Reactivity Differences and Mental Health Symptoms in Children with Neurodevelopmental Conditions and Their Neurotypical Peers

Received: 28 July 2021;  Published: 25 October 2021;  doi: 10.21926/obm.neurobiol.2104110


Children with neurodevelopmental conditions (NDC) often have sensory reactivity differences, such as being overwhelmed by sounds, which can elicit distress in their everyday life. Furthermore, children with an NDC often present with a greater frequency of mental health symptoms compared to their typically developing peers. However little research has examined the relationship of these sensory reactivity differences on broader mental health. This study set out to explore the relations [...]

Open Access Review

Narrative Review of Surgery for Myasthenia Gravis

Received: 25 June 2021;  Published: 15 October 2021;  doi: 10.21926/obm.neurobiol.2104109


Myasthenia Gravis (MG) is a rare autoimmune disorder characterized by antibody mediated blockade of neuromuscular transmission. Up until the last decade, evidence suggesting benefit of thymectomy for myasthenia gravis has been based on non-randomized control studies. Our paper serves as an expert narrative review of new literature pertaining to surgical management of myasthenia gravis based on review of articles from PubMed and Cochrane database from date of inception through June 14, 2021. We u [...]

Open Access Review

Antidepressant Treatment of Depression in the Elderly: Efficacy and Safety Considerations

Received: 07 February 2021;  Published: 14 October 2021;  doi: 10.21926/obm.neurobiol.2104108


Depression in the elderly is a significant clinical problem which is likely to endure as an ongoing issue as the cohort of individuals aged over 65years continues to increase as a proportion of the total population. While there are a multiplicity of approaches to the treatment of depression, the mainstay for moderate to severe cases is pharmacotherapy. The majority of extant antidepressants have demonstrated efficacy, at least in short term (6-12weeks) clinical evaluations. There is [...]