OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 7.5 weeks; Submission to Acceptance: 15.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Topical Collection
New Developments in Brain Injury
Editor
Lynne Ann Barker, PhD Reader in Cognitive Neuroscience
Department of Psychology, Sociology and Politics, Sheffield Hallam University, Sheffield, United Kingdom
Website | E-Mail
Research Interests: Neuropsychology; Cognitive Neuroscience; Brain Trauma; Cognitive assessment; Biomarkers of Neuropathology, Novel Interventions and Therapeutics
Topical Collection Information
Estimates of incidence of brain injury across the globe vary considerably, but it is clear that brain injury remains a major cause of death and disability, particularly in youth. Advances in critical care mean that most have normal life expectancy but quality of life is frequently, sometimes devastatingly, compromised. There is an urgent need for new approaches, interventions, therapies, treatments and diagnostic tools that better assess real world capacity and draw on new technologies and advances in science. One particular topic of interest is inconsistency around severity diagnosis (e.g. when to start measuring PTA and GCS, particularly if someone is in a coma or the injury is mild in nature,) and the impact this has on brain injury statistics and rehabilitation. It is a critical priority to develop new ways of standardizing this process. In this special edition we invite submissions that specifically embrace this new spirit of innovation in brain injury assessment, treatment and research. Our aim is to showcase new, inventive and original approaches to longstanding issues in brain injury research and neurorehabilitation.
Planned Papers
Title: Role of Erythropoietin in Brain Injury
Authors: Stephana Carelli , Michele Samaja
Affiliation: Department of Health Science, University of Milan, Italy
Abstract: Erythropoietin (EPO), widely known as an erythropoietic hormone, is recognized as a protective messenger in several biological systems, including the cerebrovascular. A downstream protein whose synthesis is triggered by hypoxia-related stresses, EPO exerts its anti-apoptotic and anti-inflammatory effects through its receptor and the activation of the STAT3 pathways, as demonstrated especially in traumatic spinal cord injury. However, it appears that EPO may be related to non-hypoxia-related pathways, such as in Parkinson’s disease, and that hyperoxia, a condition opposite to hypoxia, may be as deleterious as hypoxia in generating brain injury. We will review these mechanisms, evaluating also the potential use of EPO mimics as potential therapeutic targets.
Title: Matrix metalloproteinases in central nervous system development and repair
Authors: Holly Colognato
Affiliation: Department of Pharmacology, Stony Brook University, Stony Brook, NY 11794-8651, USA
Title: Analysis of 16 Coils Over 50 MRI-derived Head Models in Transcranial Magnetic Stimulation
Authors: Philippe simon
Affiliation: Recherche clinique, Hôpital d’Instruction des Armées Sainte-Anne, Toulon, France
Publication (13 papers)
Abstract
| Stroke is the second and third leading cause of death and disability, respectively, all over the world. It seriously affects patients' lives and brings huge burdens to their families. Ischemic stroke accounts for most of the stroke cases. In the absence of any effective treatment, prevention measure [...] |
Abstract
| Neuroleptic Malignant Syndrome (NMS) and Malignant Catatonia (MC) are conditions with significant overlap and are classically characterized by autonomic dysfunction, rigidity, bradyreflexia, posturing, lead-pipe rigidity in the former and waxy flexibility in the latter, stereotyping, an increase in [...] |
Abstract
| Catatonia, particularly malignant catatonia (MC), continues to manifest in severe sequalae such as hyperthermia, rhabdomyolysis, cardiovascular collapse and failure, and even death as, although identification of the syndrome has significantly improved once its developed, several precarious factors c [...] |
Abstract
| Catatonia and malignant catatonia may result in devastating and life-threatening complications like pulmonary embolisms, pneumonia, deep venous thrombosis, rhabdomyolysis, and even death. There have been documented cases implicating alcohol withdrawal as a significant culprit in catatonia. Here, we [...] |
Open Access
Research Article
Abstract
| Brain training apps are becoming increasingly popular for at home use and as an adjunct to more traditional therapies. There is uncertainty about whether the effects of brain training transfer to real-world cognition, or performance on other cognitive assessment tests, or is specific onl [...] |
Abstract
| Hypoxic-ischemic encephalopathy is a major cause of death and disability in the newborn period. Experimental models have demonstrated that brain injury in hypoxic-ischemic encephalopathy occurs in two phases: primary energy failure and secondary energy failure. In primary energy failure, there is a [...] |
Abstract
| Case studies have associated catatonia with withdrawal from benzodiazepines and clozapine, both of which have been shown to increase GABA activity. Long-term use of GABAergic medications could result in GABAA downregulation and sudden discontinuation of the GABAergic drug could lead to a GABA hypoac [...] |
Abstract
| Agitation is a common manifestation of acute brain injury. When not addressed, agitation can lead to slower recovery rates, including delayed admission to acute rehabilitation programs. Antipsychotics are commonly used to control agitation in acute brain injury in the ICU. However, there is no curre [...] |
Abstract
| (1) Background: Sport-related concussion is a growing public health concern. Defined as a functional injury, concussion is characterised by a constellation of signs and symptoms. However, clinical imaging methods do not reveal any structural damage. Recently, neurophysiological techniques such as tr [...] |
Open Access
Research Article
Abstract
| Background: Hundreds of experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. The translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-methyltin poi [...] |
Abstract
| Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white [...] |
Abstract
| Purpose of review:
The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as salvage therapy for severe cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The charac [...] |
Abstract
| Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury and the mechanisms have not been completely found out yet. The causative factors of brain injury initiated by aneurysm rupture, which is called as early brain injury (EBI), consists of elevated intracranial pressure, cerebral hypo [...] |
Yang Xu
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