Biological Age versus Chronological Age in the Prevention of Age Associated Diseases
Abstract
(ISSN 2638-1311)
OBM Geriatrics is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.
Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.
Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.
Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.7 weeks; Submission to Acceptance: 17.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Perspectives on Telomeres and Aging
Submission Deadline: January 31, 2019 (Open) Submit Now
Guest Editor
Michael Fossel, MD, PhD
1. President of Telocyte (http://www.telocyte.com), Grand Rapids, MI 49503, USA
2. Retired Clinical Professor of Medicine, Michigan State University, Ada, MI 49301, USA
Research Interests: human aging; telomeres; telomerase therapy; age-related diseases; Alzheimer's disease
About This Topic
Geriatrics aims to treat the diseases of older human beings, an aim that we have consistently failed to achieve with any great efficacy. Yet both theory and growing experimental data suggest that this is about to change significantly, largely due to an increased understanding of the role played by changes in gene expression in senescent cells that result in aging disease. This is not merely a conceptual revolution, but has practical, clinical implications: we have the nascent ability to treat disease by extending telomeres and thereby resetting gene expression. The experimental results in animal studies have been remarkable and FDA human trials are planned.
Beyond the few interventional trials with telomerase activators and the planned human trials with telomerase gene therapy, there is also a growing literature on the relationship between telomere lengths and aging and, more importantly, age-related disease.
Geriatrics will publish a special issue on the relationship between telomeres and aging. We encourage submission of research on the role of telomeres (and telomerase) in geriatric medicine, to specifically include articles giving a perspective on the diagnostic and therapeutic potential of telomeres and aging.
Planned Papers
Title: Telomeres in Aging, Development, and Longevity
Author: Alvaro Macieira-Coelho
Title: Telomere, stress, stress-related mental disorders and aging
Author: Lei Zhang
Title: Telomeres and Heart failure in Aging patients
Author: Bodh I. Jugdutt
Affiliation: 2C2 W.C. Mackenzie Health Sciences Centre, Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta and Hospitals, 8440-112 Street, Edmonton, Alberta, Canada
Title: Biological Age versus Chronological Age in the Prevention of Age Associated Diseases
Authors: Gian Andrea Rollandi 1, *, Aldo Chiesa 1, Nicoletta Sacchi 1, Matteo Puntoni 1, Adriana Amaro 2, Ulrich Pfeffer 2, *
Affiliations:
1. Ente Ospedaliera Galliera, Genova, Italy;
2. IRCCS Ospedale Policlinico San Martino, Genova, Italy;
Title: Telomeres in Aging, Development, and Longevity
Author: Alvaro Macieira-Coelho
Abstract:
It has been postulated that telomere shortening is a main cause of cell proliferative senescence and of organism aging. This statement is based on the following propositions: The number of divisions of cells in vitro is inversely related with telomere length and with the age of the donor, hence telomere length is inversely related with age of the organism. The propositions, however, have not been ascertained. Indirect and circumstantial evidences suggest that some developmental events are regulated at the level of telomeres. Telomeres also seem to influence positively or negatively species longevity depending upon their role on chromosomal recombination, which can confer genetic stability or instability.
Title: Cross-talk between Genetic Modulators of Human Longevity & Telomeres
Authors: Trevor Torigoe, Bradley Willcox, Craig Willcox, Michio Shimabukuro, Richard Allsopp
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (geriatrics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
Welcome your submission!
Publication
Biological Age versus Chronological Age in the Prevention of Age Associated Diseasesby
Gian Andrea Rollandi
,
Aldo Chiesa
,
Nicoletta Sacchi
,
Mauro Castagnetta
,
Matteo Puntoni
,
Adriana Amaro
,
Barbara Banelli
and
Ulrich Pfeffer
Abstract Aging is associated with an increasing incidence of major diseases among which cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome and quality of life and are commonly applied as age-dependent indications based on [...] |
hTERT Promoter Regulation by Differentiation Mechanisms vs Telomerase Activity in Somatic, Embryonic, and Cancerous CellsAbstract Telomere shortening in the somatic cells is one of the most well-documented factors of cellular ageing. Telomeres are composed of tandem hexanucleotide repeats that protect cells from unwanted recombination mechanisms, secure the ends of chromosomes and their stability, and are responsible for limited division capacity. Telomerase is an en [...] |
Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and HostilityAbstract Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to stressors show notable circulating inflammato [...] |
Cell Senescence, Telomerase, and Senolytic TherapyAbstract The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable attention, but both theoretical consideration [...] |
Telomere Editorial - Perspectives on Telomeres and AgingAbstract Telomere Editorial-Perspectives on Telomeres and Aging |
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