by Khue Vu Nguyen

Received: 18 January 2018;  Published: 31 January 2018;  doi: 10.21926/obm.genet.1801012

With the increasing ability to control infectious and nutritional diseases in developed countries, there has come the realization that genetic and epigenetic regulation in diseases are a major cause of disability, death, and human tragedy. Here, I discuss current knowledge about this matter including the diagnosis, counseling, treatment and management as well as some current therapeutic interventions such as gene, stem cell, epigenetic therapies and future directions in the field.

by Chunhui Xie  , Lillian Ye  , Yeh-Chuin Poh  and George Harb

Received: 06 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.transplant.1903072

Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represent an ideal tissue type for single cell transcriptomic analysis. Adult human islets consist of five known endocrine cell types (α, β, δ, γ, ε) and multiple less well-defined non-endocrine cells. In this review, we discuss [...]

by Dagan Coppock  , Caytlin Deering  , Shara Epstein  and Dong Heun Lee

Received: 23 December 2018;  Published: 01 March 2019;  doi: 10.21926/obm.transplant.1901054

Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation of PCTs value in the different types of infections, transplanted organs, and post-operative courses can be challenging. We review the role of PCT in the management of infections in SOT recipients. First, the PCT level c [...]

by Ami Rokach

Received: 09 November 2022;  Published: 17 May 2023;  doi: 10.21926/obm.geriatr.2302236

Social support has been shown to have many positive effects on our lives, health, and ability to grow and flourish. Lack, or diminished social support results in loneliness. This thematic review focuses on the elderly, and the loneliness that is part of the life of many of them. The review highlights the social connections and the expectations that the elderly may have of them, and how being connected to others may alleviate, loneliness. Loneliness is known to negatively affect one’s health, social life, familial r [...]

by Hironari Minami  , Hiroaki Izumi  , Takumi Hasegawa  , Fan Bai  , Daisuke Mori  , Sou Taminato  , Yasuo Takeda  , osamu yamamoto  and Nobuyuki Imanishi

Received: 30 June 2021;  Published: 23 September 2021;  doi: 10.21926/jept.2103041

Rechargeable batteries with higher energy and power density exceeding the performance of the currently available lithium-ion batteries are suitable for application as the power source in electric vehicles (EVs). Aqueous lithium-air batteries are candidates for various EV applications due to their high energy density of 1910 Wh kg-1. The present study reports a rechargeable aqueous lithium-air battery with high power density at room temperature. The battery cell comprised a lithium anode, a non-aqueous anode electro [...]

by Sravanthi Nandavaram  , Hannah Twist  , Rickey Evans  , Sravanthi Paluri  , Ana Castellanos  and Andres Pelaez

Received: 31 January 2024;  Published: 10 April 2024;  doi: 10.21926/obm.transplant.2402211

Thrombotic Microangiopathy (TMA) is a syndrome characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The presence of schistocytes on peripheral smear, a negative Coombs test, elevated lactate dehydrogenase, increased reticulocyte count and low haptoglobin are often the clues for MAHA. The microvascular process often targets vasculature in kidneys, brain, gastrointestinal system, heart, and skin. A timely diagnosis and treatment are often crucial to prevent severe end organ damage and death [...]

by Marina Maier  , Amela Ajanovic  and Reinhard Haas

Received: 23 June 2024;  Published: 06 December 2024;  doi: 10.21926/aeer.2404026

The transport sector accounts for approximately 25% of CO2-emissions in the EU and Austria, primarily due to passenger car transport powered by fossil fuels. Replacing conventional cars with sustainable alternatives is crucial for reducing emissions, improving air quality, and mitigating climate change while decreasing vehicle kilometers driven. This study analyzes policy strategies for Austria’s road passenger transport sector up to 2050 to determine their potential for significant CO2 reduction. Four scenar [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 09 November 2022;  Published: 28 April 2023;  doi: 10.21926/obm.neurobiol.2302167

This expanded conference paper reports the results of a psychophysiological research study on shared intentionality conducted in 24 online experiments with 405 subjects (208 recipients and 197 contributor-confederates). In this research, we created a bioengineering system for assessing shared intentionality in human groups by modeling mother-neonate dyad properties in subjects during solving unintelligible multiple-choice puzzles. In this model, only the mother (contributor-confederate) knows the correct stimulus a [...]

by Jeamichel Puente Torres  , Harold Crespo Sariol  , Thayset Mariño Peacok  , Ángel Brito Sauvanell  , Greet Cuyvers  , Guy Reggers  , Pieter Samyn  , Dries Vandamme  , Jan Yperman  , Peter Adriaensens  and Robert Carleer

Received: 25 October 2022;  Published: 21 April 2023;  doi: 10.21926/aeer.2302028

The chemical regeneration of exhausted granular activated carbon (GAC) from a water treatment plant to produce dialysis water used in hemodialysis treatments for chronic renal disease patients from a general Hospital of Ciego de Avila province, Cuba, was investigated. Activated carbon (AC) exhausted mainly by inorganics (Ca (Ca-chelates), Mg and Na) was regenerated using hydrochloric acid and acetic acid (one regeneration cycle). Solutions of 5%, 10%, 15% and 20%(v/v) as well as four contact times (2 h, 4 h, 6 h an [...]

by Elysa Nensy Irawan  , Sandro Sitompul  , Ken-Ichiro Yamashita  and Goro Fujita

Received: 05 October 2022;  Published: 02 January 2023;  doi: 10.21926/jept.2301001

This research aims to know the effect of the Rotor Radius Ratio on the performance of the hybrid Vertical Axis Wind Turbine Savonius-Darrieus NREL S809 model using the Computational Fluid Dynamics method. Two-bladed Savonius is used as an internal rotor, and three-bladed Darrieus NREL S809 as an external rotor. Turbine model performance is analyzed through the value of the Moment Coefficient and Power Coefficient. The result shows that the increase in the Rotor Radius Ratio value causes an increase in the initial M [...]

by Brandis M. Ansley  and Meagan A. Wander

Received: 07 July 2021;  Published: 28 October 2021;  doi: 10.21926/obm.icm.2104039

Self-Care Options for Resilient Educators (SCORE) is an 8-week, asynchronous virtual training program that teaches stress management skills relevant to educators’ job-related responsibilities and interpersonal interactions. From January-April 2020, 27 pre-service teachers participated in a quasi-experimental study of SCORE’s feasibility and preliminary efficacy. Volunteers chose to either complete SCORE concurrent with their teaching internship or to complete the same assessments for comparison purposes. Recruitmen [...]

by Kikuko Hayamizu  , Tomoyuki Haishi  , Yasuhiko Terada  , Kunimitsu Kataoka  and Junji Akimoto

Received: 24 January 2023;  Published: 03 April 2023;  doi: 10.21926/rpm.2302014

Pulsed field-gradient (PFG) NMR spectroscopy was applied to thin disk samples (0.5, 1 and 2 mm thick, 4 mm diameter) of LLZO-Ta (Li6La3Zr1.5Ta0.5O12) single crystal. We have measured the diffusion of 7Li in thin pellets (0.5 to 3 mm thick) of NASICON-type LAGP powder and found that the Li+ diffuses preferentially in the thicker direction. In this study, we placed 1 mm thick, 4 mm diameter disk-shaped single crystals vertically, i.e., parallel to the PFG direction. We found that 7Li ions diffuse similarly as in rod- [...]

by Laxminarayan Sahoo  , Payal Murmu  , Mohan Krishna Ghanta  and LVKS Bhaskar

Received: 28 June 2025;  Published: 30 October 2025;  doi: 10.21926/obm.genet.2504314

Ebstein's anomaly (EA) is a rare form of congenital heart disease (CHD), characterized by abnormal cardiac anatomy involving a defective tricuspid valve (TV), resulting in tricuspid regurgitation (TR) and cyanosis. EA is represented in different case scenarios with varying degrees of complexity across various age groups. It usually affects 0.2-0.7 out of 10,000 live births and accounts for 0.3%-0.6% of all CHD cases. While its occurrence is mainly sporadic, evidence from multiple studies suggests that EA can be ass [...]

by Trenton Cersoli  , Muneer Barnawi  , Kerry Johnson  , Edward Burden  , Frank Li  , Eric MacDonald  and Pedro Cortes

Received: 17 February 2022;  Published: 29 April 2022;  doi: 10.21926/rpm.2202009

Shape memory polymers (SMPs) are smart materials that can respond to certain thermal, chemical or electrical stimuli by inducing a structural conformation change into a temporary shape. In this work, a 3D printing process based on a Vat Photo-polymerization of a shape memory polymer (SMP) was investigated to produce customized smart and complex morphable antennas. The mechanical and material properties were examined through a tensile, flexural and rheological testing for different polymer mixture ratios. It was obs [...]

by Franco Cracolici  , Simonetta Bernardini  and Rosaria Ferreri

Received: 14 October 2018;  Published: 30 January 2019;  doi: 10.21926/obm.icm.1901006

Background: Acupuncture is an innovative and scientifically supported treatment for oncologic patients, as well as an effective palliative care option. At the Palliative Care Department of "Misericordia" Grosseto Hospital in Tuscany, real integration of acupuncture in palliative medicine has been possible. The objective of this work is to retrospectively evaluate patient treatment outcomes obtained using an integrated medical care approach administered within a palliative care unit. Methods: Medical records of onco [...]

by Vidhula R Ahire  , Amit Kumar  , Sushma Bhosle  and Kaushala Prasad Mishra

Received: 22 September 2020;  Published: 14 May 2021;  doi: 10.21926/obm.genet.2102129

Ellagic acid (EA) is a polyphenol found in grapes, pomegranates, walnuts, etc. exhibits anti-cancer properties. The current study was conducted to understand the radiosensitizing role of EA on HeLa cells. Monotherapy of EA and radiation was initially studied on HeLa cells. The addition of EA before the radiation treatment subsequently made DNA more susceptible to damage thereby developing DNA beaks, which are known to be lethal for cell survival. This was evaluated by performing comet and γ-foci formation ass [...]

by Noorhazlina Ali  , Cai Ning Tan  , Jasmine Kang  , Aik Phon Chew  , Caroline Caroline  , Mary Lee  and Wee Shiong Lim

Received: 27 October 2020;  Published: 04 December 2020;  doi: 10.21926/obm.geriatr.2004140

A locally-adapted, multisensory, psychosocial intervention called Namaste Care program was developed to improve the daily life of persons with advanced dementia (PwAD) through arranging meaningful activities and physical interactions by healthcare staff (Namaste Carers). Congruent with Asian values, the families of PwAD were invited to participate in Namaste Care sessions. The study aimed to explore the influence of Namaste Care on cognitive status and quality of life (QOL) of PwAD, and perceptions and attitudes of [...]

by Renate Verkaik  , Iris van der Heide  , Eugenie van Eerden  , Peter Spreeuwenberg  , Erik Scherder  and Anneke L. Francke

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.geriatr.1904092

Background: Studies conducted on the effectiveness of psychosocial interventions have indicated that sensory stimulation represents a promising approach to reduce the psychological and behavioral disturbances in people with dementia. Multi-sensory stimulation involves the simultaneous stimulation of multiple senses, through the use of various methods, for example, by using a variety of lights, gentle stimulating music, aromas, and tactile objects, among others. A relatively novel approach is the enriched thematic m [...]

by Muhammad Ismail

Received: 09 November 2022;  Published: 15 March 2023;  doi: 10.21926/cr.2301014

Silver nanoparticles have been utilized in an easy, sensitive, and effective approach through spectrophotometry and spectrofluorimetry to quantify urea in water samples. Here, 1,3-di-(1H-imidazole-1-yl) -2-propanol (DIPO) was employed to stabilize Ag NPs produced from the reduction of aqueous silver nitrate by sodium borohydride (NaBH4). Beer-Lambert's law was applied for determination using the complexation of Ag NPs with urea molecules. The results show urea can be assessed concurrently with good results and perc [...]

by Parisa Gazerani

Received: 09 May 2018;  Published: 10 October 2018;  doi: 10.21926/obm.genet.1804040

Interactions between genetic and environmental factors in migraine are well known and can potentially determine an individual’s susceptibility to disease and responsiveness to treatment. Consequently, several epigenetic studies have been conducted to determine if and how genes are activated or inactivated in response to a diverse range of environmental migraine triggers. The results, in turn, have helped elucidate how these factors can promote or inhibit migraine progression or therapeutic response and can guide de [...]

by Rene J. Duquesnoy  and Marilyn Marrari

Received: 13 December 2019;  Published: 10 February 2020;  doi: 10.21926/obm.transplant.2001099

Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus class II eplets shared between HLA-DR, HLA-DQ and/or HLA-DP alleles. This report summarizes current information about antibody-verified interlocus class II eplets. It describes a structural modeling method to determine po [...]

by Jaclyn B. Murry  and Ying S. Zou

Received: 30 June 2022;  Published: 07 November 2022;  doi: 10.21926/obm.genet.2204168

Double aneuploidy is the co-occurrence of aneuploidy of two different chromosomes within the same individual. Genomic imbalance associated with two aneuploidies in humans is associated with early lethality, and observation in live-born humans is rare. In isolation, trisomy of chromosomes 13, 18, 21, X, and Y may be better tolerated, whereas monosomy of X is the only such type of aberration that may be compatible with life. It is hypothesized that two successive malsegregation events must occur in early development [...]

by Lucy Wyatt

Received: 24 November 2020;  Published: 22 January 2021;  doi: 10.21926/jept.2101005

This paper presents the case for the use of HF radar to provide wave, current and wind measurements and maps during the surveying, resource and impact assessment, construction, maintenance and performance assessment phases of an offshore fixed or floating wind farm or other marine renewable project. The data presented are from the Celtic Sea which is currently the focus of a lot of offshore wind interest. The data are from a dual radar system deployed at the Wave Hub site off the Cornwall coast since 2011, a single [...]

by Ghazaleh Ramezani  , Theo G. M. van de Ven  and Ion Stiharu

Received: 20 September 2024;  Published: 21 January 2025;  doi: 10.21926/rpm.2501004

This study investigates the hypothesis that diverse synthesis techniques can yield cellulose-graphene hybrids with tailored properties for specific applications, enabling advancements in flexible electronics, energy storage, environmental remediation, and biomedical devices. We examined and compared multiple synthesis methods, including chemical reduction, in-situ synthesis, green synthesis using natural reducing agents, solvent-assisted approaches, hydrothermal and solvothermal techniques, mechanical and chemical [...]

by Kory Floyd  , Nathan Woo  , Benjamin Custer  , Dana Dinsmore  , Kaylin Duncan  and Jeannette Maré

Received: 07 January 2022;  Published: 19 April 2022;  doi: 10.21926/obm.neurobiol.2202119

Loneliness is a common condition that poses substantial risks to morbidity and mortality. Cacioppo and Cacioppo’s [1] evolutionary theory of loneliness (ETL) provides that loneliness serves a social signaling function and also manifests in hypervigilance to threat, which we propose can influence person perception. In this experiment, 480 observers evaluated videotaped self-presentation messages from speakers who scored either high or low on a measure of loneliness. On the basis of ETL, we hypothesized that observer [...]