by Corrado Angelini

Received: 06 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.icm.2402035

An 83-year-old man with myasthenia gravis was hospitalized in the ICU; support for caregivers of elderly myasthenic patients in the ICU can be a crucial aspect of their care. Myasthenia gravis is a chronic autoimmune neuromuscular disease that can cause varying levels of muscle weakness, which can significantly impact the patient's day-to-day activities and overall quality of life. This intervention was followed for over one month with success. The critical phases are presented and analyzed as a medical support art [...]

by Oyovwi Mega Obukohwo  , Oyelere Abosede Oreoluwa  , Odewale O. Comfort  and Afolabi Opeyemi Olanike

Received: 24 March 2024;  Published: 20 June 2024;  doi: 10.21926/obm.genet.2402246

Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand t [...]

by Fatemeh Mollaamin  , Majid Monajjemi  and Ahmad R. Alsayed

Received: 22 February 2024;  Published: 19 June 2024;  doi: 10.21926/obm.genet.2402245

The potential and selective inhibitors of protein tyrosine phosphatase 1B (PTP1B) are therapeutically useful in treating type 2 diabetes. N-Benzoyl-L-glutamyl-[4-phosphono(difluoromethyl)]-L-phenylalanine-[4-phosphono(difluoro-methyl)]-L-phenylalanineamide (BzN-EJJ-amide) (BGD) which is the ligand of 1LQF protein code extracted from protein data bank (PDB) is an inhibitor of PTP-1B that indicates selectivity over several protein tyrosine phosphatases. In this research, the interaction between the anti-diabetic drug [...]

by Mohammed Mustafa  , Salman Pervaiz  and Ibrahim Deiab

Received: 23 February 2024;  Published: 18 June 2024;  doi: 10.21926/rpm.2402013

This paper investigates the effect of rake angle, α, cutting edge radius, r, and feed rate, f, on the cutting force and cutting zone temperature during orthogonal dry cutting of Ti6Al4V. A numerical model representative of the 2D orthogonal cutting process is developed using ABAQUS/Explicit software. Johnson-Cook, (JC) constitutive material model is used to describe material plasticity. JC damage model and energy-based fracture criterion are used to describe damage initiation and evolution. Using Minitab-19 softwar [...]

by Galal Khamis  , Jun Chi  and Qingshun Zhao

Received: 12 January 2024;  Published: 18 June 2024;  doi: 10.21926/obm.genet.2402244

Tomato (Solanum lycopersicum), a family of Solanaceae, is an annual crop grown in fields and greenhouses. Tomato is the fourth-largest agricultural crop in the world, with a market value of more than $50 billion. Numerous attempts were conducted on the tomato for further improvement via in vitro regeneration and transformation. This study aims to establish in vitro multiplication, transformation, and gene editing systems in tomatoes by using cotyledon explants. Cotyledon explants were placed on the MS medium suppor [...]

by Ala'a A. AI-yyan  , Ayat A. ELayan  and Mohammad Saleh

Received: 28 February 2024;  Published: 16 June 2024;  doi: 10.21926/obm.neurobiol.2402226

The progressive muscle relaxation technique (PMRT) is an active method that is defined as a technique through which individuals gradually cause a feeling of quietness and coolness by actively contracting and loosening specific muscle groups. The purpose of this study was to review the effectiveness of using progressive muscle relaxation techniques on quality of life, stress, and anxiety levels among Acute Myocardial Infarction patients. A systematic review of randomized controlled trials (2013-2023). Databases of P [...]

by Balamurugan Sivaprakasam  and Prasanna Sadagopan

Received: 24 December 2023;  Published: 14 June 2024;  doi: 10.21926/obm.genet.2402243

The present study introduces Snips2HLA-HsG, an integrated application designed for SNP genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful ensemble classifier technique from the Bioconductor HIBAG package, Snips2HLA-HsG offers a comprehensive response for genetic analysis. Accessible via https://snips2hla.shinyapps.io/hla_home/, the application distinguishes itself by prioritizing user-friendliness and integrating all-purpose functionalities, including sample preparation, mode [...]

by Charitha Thambiliyagodage  , Madara Jayanetti  , Geethma Ekanayake  , Amavin Mendis  , Heshan Liyanaarchchi  and Supuni Wijayawardana

Received: 10 April 2024;  Published: 13 June 2024;  doi: 10.21926/cr.2402006

Ilmenite is a mineral whose crystallinity can be altered by chemical treatment, producing TiO2 and iron and titanium-based metal nanocomposites, which are applicable mainly for photocatalysis. Porous and crystalline biomass-derived carbon materials include graphene oxide, reduced graphene oxide, graphitic carbon nitride, catalytically graphitized sucrose and chitosan, and activated carbon. Ilmenite-based metal oxides coupled with biomass-based carbon materials are effective in environmental remediation, especially [...]

by Rodolfo Pessina  , Fabrizia Colmegna  , Massimo Clerici  and Ester di Giacomo

Received: 26 December 2023;  Published: 13 June 2024;  doi: 10.21926/obm.icm.2402034

Therapeutic termination of pregnancy (TToP) is performed for maternal health risks or severe fetal malformations. Research focuses on women's psychopathological outcomes after TToP, noting that 10-22% of women experience psychiatric disorders, especially depressive symptoms and post-traumatic stress disorder (PTSD). However, little is known about paternal mental outcomes. This study analyzed biological fathers' mental health at a 1-year follow-up after TToP. Results indicate biological fathers show no alarming psyc [...]

by Buti Obaid Saeed Alfalahi  , Imane Lamdjad  , Mustafa Alnujaifi  , Noaman Atallah Alheety  and Abdul Qayyum

Received: 05 February 2024;  Published: 12 June 2024;  doi: 10.21926/obm.genet.2402242

Understanding the impact of melatonin (N-acetyl-5-methoxytryptamine) on plant gene expression is crucial for unlocking its full potential as a tool for crop improvement and stress tolerance. Melatonin has emerged to have several influences on the transcriptional activity of numerous genes, helping to orchestrate plant responses to environmental cues. Furthermore, it has been shown that melatonin signaling pathways control downstream gene expression to ensure proper plant growth and development. Therefore, clearing [...]