by Phumzile Mkhize  and Phetole Mangena

Received: 16 July 2024;  Published: 16 October 2024;  doi: 10.21926/obm.genet.2404267

Breeding drought-tolerant genotypes using genetic and biochemical tools is an important mitigation strategy to improve stress response and yields in bottle gourd [Lagenaria siceraria (Molina) Standl.]. This current study evaluated the variations among bottle gourd genotypes for potential breeding purposes by establishing the relationship between agronomic traits and the protein profile required for the plants’ resilience against drought stress. The study assessed 12 bottle gourd accessions grown under non-str [...]

by Beren Crim Sabuncu  , Ankica Kosic  and Amy L. Ai

Received: 20 January 2024;  Published: 15 October 2024;  doi: 10.21926/obm.icm.2404059

The Covid-19 pandemic has brought forth global challenges in socioeconomic, political, and public health dimensions. For many, spirituality was a powerful source of support during this pandemic experience. The current review provides an apt overview of spirituality as a coping method to mitigate the mental and emotional impact of global turmoil of Covid-19 within the context of Europe. Using select studies from Czechia, Italy, and Turkey which have low, middle, and high religiosity indexes respectively, the potenti [...]

by Jozélio Freire de Carvalho  and Aaron Lerner

Received: 20 June 2024;  Published: 12 October 2024;  doi: 10.21926/obm.icm.2404058

To systematically review the literature for cases using homeopathy in which complete healing was observed. Scielo, Pubmed, CINAHL, and Embase databases were systematically screened for case reports and series of patients successfully cured by homeopathy between 1966 and August 2022. Language limitation was not used. Forty-nine articles, comprising 191 patients, were depicted. Most of them had dermatological conditions (12 papers, 71 patients), followed by infectious (7 papers, 31 patients), neuropsychiatric (10 pub [...]

by José A. Cedeño-Escudero  , Luis A. Sotillo-Bent  , Carolina Vega- Cuellar  , Rolando González-Angulo  , Evelyn Medina-Batista  , José Sotillo-Lindo  and Luis A. Méndez-Rosado

Received: 13 August 2024;  Published: 12 October 2024;  doi: 10.21926/obm.genet.2404266

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy, affecting approximately 1 in 500 people. It is the most common genetic cardiomyopathy inherited as a Mendelian trait in approximately 50% of patients, mainly due to pathogenic variants in genes encoding sarcomeric proteins. Mutations in the sarcomeric protein filamin C (FLNC) gene, with a cytogenetic localization on 7q32.1, have been linked to hypertrophic cardiomyopathy, as they have been determined to increase the risk of ventricular a [...]

by Rohman Hikmat  , Iyus Yosep  , Efri Widianti  , Suryani Suryani  , Aat Sriati  and Icih Susanti

Received: 20 July 2024;  Published: 12 October 2024;  doi: 10.21926/obm.neurobiol.2404249

To describe the application of the Stuart Stress Adaptation and Nola Pender Models in mental nursing care for a patient with schizophrenia and risk of violent behavior. This research method used case studies. The sample is one patient with schizophrenia. Data collection is done through direct observation, interviews, and patient medical records. The results showed that the client showed a major nursing problem in the form of risk of violent behavior. Predisposing factors included passive childhood experiences and s [...]

by Danilo Donati  , Giacomo Farì  , Federica Giorgi  , Vincenza Amoruso  , Valentina Boetto  , Riccardo Marvulli  , Laura Dell'Anna  , Andrea Bernetti  and Roberto Tedeschi

Received: 31 May 2024;  Published: 10 October 2024;  doi: 10.21926/obm.neurobiol.2404248

This review examines the effectiveness of integrating botulinum toxin type A (BONT-A) with various rehabilitative strategies in treating spastic diplegia in children. The studies analyzed consistently demonstrate significant reductions in spasticity and improvements in gait when BONT-A is combined with interventions such as intensive physical therapy, serial casting, electrical stimulation, physiotherapy, occupational therapy, and robotic-assisted gait training. The findings underscore the importance of personalize [...]

by Elga J. Vargas  , Julio C. Martinez  and Lina A. Gomez

Received: 26 April 2024;  Published: 03 October 2024;  doi: 10.21926/obm.transplant.2404225

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In regenerative medicine, biomolecules are fundamental to tissue regeneration. The use of growth factors from autologous platelet-rich plasma emerges as a promising alternative in the treatment of acne and scars. This study [...]

by Mohammad Shabani  , Elham Hassanpour  , Fatemeh Aghighi  , Mojgan Mohammadifar  , Fereshteh Bahmani  and Sayyed Alireza Talaei

Received: 11 May 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403247

Diabetic neuropathy (DN) is a type of nerve damage caused by long-term hyperglycemia in diabetes mellitus (DM). The gut microbiota alters in DM. Therefore, improvement of the gut flora may affect neuropathic pain and oxidative biomarkers' responsiveness to the probiotic treatment. The present study aimed to assess the effects of probiotic supplementation on neuropathic pain and oxidative stress biomarkers in diabetic rats’ serum. Forty-eight rats (200-250 g) were randomly divided into four groups (n = 12 [...]

by Mahintaj Dara  , Zahra Karimi  , Mehdi Dianatpour  and Hadi Aligholi

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

by Meshari A. Alzahrani  , Mohammad A. Alghafees  , Lama H. Aldosari  , Abdulaziz K. Almaymuni  , Abdulltaif M. Altalhah  , Mohammed M. Abualgasem  and Basel O. Hakami

Received: 19 April 2024;  Published: 30 September 2024;  doi: 10.21926/obm.genet.2403265

The total lack of spermatozoa in the ejaculate is known as Azoospermia. It is the most severe and significant contributor to male infertility. Therefore, the purpose of this study is to assess the status of Azoospermia and its etiologic factors that contribute to male infertility in Saudi Arabia. This study included all published studies written in English that were published in Saudi Arabia. Online searches via PubMed and Google Scholar were conducted from their inception to 15 January 2023. A total of 624 studies [...]