Table of Content

Open Access Original Research

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

Received: 16 August 2024;  Published: 20 November 2024;  doi: 10.21926/obm.transplant.2404227

Abstract

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher-dose mRNA-1273 booster vaccination enrolled nineteen adult LTRs into the 50 µg (n = 8) vs. 100 µg (n = 11) groups before enrollment was terminated due to the availability of the bivalent mRNA-1273.222 vaccine [...]

853 4088

Open Access Original Research

Stability Improvement of Multimachine System Using Back-To-Back Converters

Received: 15 July 2024;  Published: 15 November 2024;  doi: 10.21926/jept.2404021

Abstract

As the penetration level of inverter-based generators continues to increase, it becomes crucial to reduce power oscillations between inverters and synchronous generators (SG) to improve system stability. This paper uses a multimachine system as the research platform and proposes a grid separation method employing a multi-terminal back-to-back converter. The converter is designed to be placed at the point of common coupling (PCC) in the original multimachine system and can divide the original grid into multiple micr [...]

1200 5278

Open Access Perspective

A Natural Serotonin Stimulant for Appetite Suppression and Targeted Eating as an Alternative to Conventional Obesity Treatments

Received: 19 July 2024;  Published: 13 November 2024;  doi: 10.21926/rpn.2404018

Abstract

Recent advances in obesity management reflect the integration of pharmacological, surgical, and behavioral interventions, yet sustainable long-term outcomes remain elusive due to high attrition rates, the complexity of protocol compliance – and for some, costs, risks, and serious side effects. This research combined a patented nutraceutical designed to naturally stimulate serotonin, a biologic hunger agonist, to thereby aid in appetite control and facilitate weight loss through ‘Targeted Eating,’ a single, unrestri [...]

920 9987

Open Access Short Report

The Brazilian Research Scenario in Green Hydrogen: A Brief Contextualization

Received: 18 April 2024;  Published: 11 November 2024;  doi: 10.21926/jept.2404020

Abstract

Hydrogen is crucial in various industrial sectors and can be obtained through different synthesis routes. However, a significant portion of its production still relies on chemical processes involving fossil fuels, resulting in hydrogen and the generation of greenhouse gases (GHGs) as the final byproduct. In alignment with the goals of the 2030 Agenda, where countries commit to implementing energy transition, hydrogen obtained through a green route has been increasingly explored by governmental and academic entities [...]

1894 9357

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...]

1000 5774

Open Access Original Research

The Development of Operational Model Integrating Digital Technologies into Public Mental Healthcare Services in Nigeria

Received: 09 July 2024;  Published: 08 November 2024;  doi: 10.21926/obm.neurobiol.2404253

Abstract

The availability and utilization of digital technologies can leverage the challenges of the sharp-depleting workforce due to the consistent migration of healthcare professionals (HCPs), the alarming ratio of the number of patients to HCPs, discretional use of digital technologies among HCPs in providing effective therapeutic interventions and mental healthcare services. This study aimed to develop an operational model that integrates digital technologies in mental healthcare service delivery for public facilities i [...]

899 5951

Open Access Original Research

Feasibility and Acceptability of a Peer Training Program to Deliver a Theory-Based Physical Activity Behavior Change Intervention to Inactive People Living With and Beyond Cancer: A Mixed Methods Study

Received: 16 July 2024;  Published: 08 November 2024;  doi: 10.21926/obm.icm.2404067

Abstract

Theory-based physical activity (PA) interventions include PA promotion strategies that can be delivered by exercise professionals, friends, family and peers. Peer-delivery presents a valuable opportunity for community implementation. Few peer-led PA interventions for people living with and beyond cancer (LWBC) report the feasibility of their peer mentor training methods. The purpose of this study was to assess the feasibility and acceptability of a peer mentor training program to deliver a behavioural PA interventi [...]

1042 5175

Open Access Original Research

CrossFit Participation and Medication Use: Observations from a UK Population Survey

Received: 01 June 2024;  Published: 08 November 2024;  doi: 10.21926/obm.icm.2404066

Abstract

Chronic diseases, responsible for 74% of global mortality, impose a substantial health burden. This study investigates the perceived effects of CrossFit, a form of functional training, on medication use in the UK population. The research aims to provide insights into how CrossFit might relate to medical interventions for individuals with long-term health conditions. The study, encompassing 1,211 UK residents (over 18yrs.) recruited via CrossFit Affiliates, involved a 14-question online survey covering information p [...]

2514 16317

Open Access Original Research

Nanostructure-Based Solid-State Energy Storage through Hydrogen Trapping in Batteries Using Materials Modelling Technique

Received: 15 August 2024;  Published: 07 November 2024;  doi: 10.21926/jept.2404019

Abstract

A comprehensive investigation on hydrogen grabbing by SiO-GeO was carried out, including DFT computations at the CAM-B3LYP-D3/6-311+G (d,p) level of theory. The data shows that if silicon elements are replaced by germanium, the H-grabbing energy will be ameliorated. Electromagnetic and thermodynamic properties of SiO, GeO, and SiO-GeO nanoclusters have been evaluated. The hypothesis of the hydrogen adsorption phenomenon was confirmed by density distributions of PDOS and LOL for hydrated nanoclusters of H-SiO, H-GeO [...]

1090 4987

Open Access Commentary

What Is Outdoor Therapy? A New Name for an Old Therapeutic Practice

Received: 21 June 2024;  Published: 07 November 2024;  doi: 10.21926/obm.icm.2404065

Abstract

Humans are integrally connected to, yet in many ways disconnected from, nature. Across cultures, nature has been celebrated and revered in religion, traditions, rituals and community connectedness. While unfavorable conditions in nature can cause harm, closer contact with nature has been shown to reduce stress, strengthen immune systems, and improve mental health and physical wellbeing. This paper briefly describes outdoor therapies and a range of nature-based interventions assisting practitioners in serving their [...]

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