by Anita H Kelleher  and Angelos K Sikalidis

Received: 09 November 2020;  Published: 05 February 2021;  doi: 10.21926/obm.hg.2101056

The Mediterranean diet (MD) is considered one of the healthiest dietary patterns due to its rich provision of phytochemicals, antioxidants, vitamins, fiber, polyunsaturated, omega-3, and short-chain fatty acids through a variety of foods. The supply of such nutrients and bioactive components can support gut health and reduce systemic inflammation, with accumulating evidence from several human studies demonstrating the utility of the Mediterranean diet in the prevention of chronic and metabolic diseases. Further stu [...]

by Seong Soo Choi  , Byung Seong Bae  , Kyoung Jin Kim  , Myoung JIn Park  , Yong Min Lee  , Hyun Tae Kim  and Soo Bong Choi

Received: 22 December 2020;  Published: 05 February 2021;  doi: 10.21926/rpm.2101004

We fabricated various nanoaperture plasmonic platforms for single-molecule detection. We fabricated nanoapertures like nanopores on a pyramid and nanoslits on an Au flat membrane using a Ga ion focused ion beam drilling technique, followed by irradiating with a high energy electron beam, dependent on the electron beam current density to obtain nanoapertures with a few nanometer sizes (circular nanopore, nanoslit pores). We examined their optical characteristics with varying aperture sizes and sample thicknesses. We [...]

by Michael Fossel  and Kurt Whittemore

Received: 26 October 2020;  Published: 03 February 2021;  doi: 10.21926/obm.geriatr.2101156

Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis and, ultimately, clinical cancer. Telomerase therapy is not only unlikely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase t [...]

by Gregor Reid  , Azza A. Gadir  , Scarlett Puebla Barragan  and Raja Dhir

Received: 11 December 2020;  Published: 01 February 2021;  doi: 10.21926/obm.hg.2101055

The human intestinal microbiota represents a complex microbial community that plays an essential role in the maintenance of host health. Over the last decade, metagenomic and metabolomic analyses have revealed the influence of intestinal microbial diversity and composition on a range of biological functions in the host. While overall taxonomic composition of the intestinal microbiome is informative, changes in spatial dynamics within the community also have profound biological significance as microbial functions ar [...]

by Collin J. Anderson  , Amanda C. Guidon  , Farrah B. Khan  , Alissa A. Thomas  , Carolyne Riehle  , Michael K. Hehir  and Noah A. Kolb

Received: 28 October 2020;  Published: 31 January 2021;  doi: 10.21926/obm.neurobiol.2101086

Lambert Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder involving loss of functional pre-synaptic P/Q-type voltage-gated calcium channels. Many cases occur as a paraneoplastic disorder, often in small cell lung cancer (SCLC). Recently, immune checkpoint inhibitors (ICI) have emerged as treatment of choice for various malignancies. While generally well tolerated, certain ICI-treated patients experience neurologic immune-related adverse events (irAEs). Here, we explore therapeuti [...]

by F.A Hamad  , E. Emenike  , Abbas Mohammed  , S. Gooneratne  and P. Russell

Received: 01 December 2020;  Published: 31 January 2021;  doi: 10.21926/jept.2101009

In this paper, the primary aim is to look at the fundamental melting/solidification processes of polyethylene glycol 1500 (PEG 1500) for energy storage - insulation to prolong the cooling time of pipelines in unexpected shut-down conditions, prevent/minimize the wax deposition, and hydrate formation. Polyethylene glycol 1500 was selected because its melting temperature is >317 K making it a suitable candidate as lagging material to prevent wax deposition and hydrate formation in subsea oil pipelines. Experim [...]

by Han Zhang  and Joseph D. Smith

Received: 09 November 2020;  Published: 30 January 2021;  doi: 10.21926/jept.2101008

Solar thermochemical reactor provides an attractive approach that utilizes the most common solar radiation as the thermal driving force to motivate the reaction between CO2 and metal oxides, which is also called metal oxide redox pair-based thermochemical cycles. The CeO2/CeO2-δ is widely used in the two-step redox process due to its advantages including fast-redox kinetics, high crystallographic stability of a wide range of reacting oxygen non-stoichiometry, and relatively high oxygen solid-state conductivit [...]

by Joep P.M. Geraedts

Received: 15 December 2020;  Published: 28 January 2021;  doi: 10.21926/obm.neurobiol.2101085

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic te [...]

by Tharshanah Thayabaranathan  , Jan Cameron  , Barbara Murphy  and Dominique A Cadilhac

Received: 06 August 2020;  Published: 28 January 2021;  doi: 10.21926/obm.geriatr.2101155

Yoga is a form of movement-based mindfulness practice that enhances the mind-body connection to benefit overall health and well-being. Although the practices of yoga are ancient traditions in the Buddhist and Hindu philosophies, scientific research regarding the impacts of yoga among people with poor cardiovascular and cerebrovascular health has only recently been undertaken. In this article, we highlight the current evidence on the potential impact of yoga on physical and psychological well-being for older adults [...]

by Dmitriy Melkonian

Received: 17 July 2020;  Published: 27 January 2021;  doi: 10.21926/obm.neurobiol.2101084

The probabilistic formalism of quantum mechanics is used to quantitatively link the electroencephalogram (EEG) with the underlying microscale activity of cortical neurons. Previous approaches applied methods of classic physics to reconstruct the EEG in terms of explicit physical models of cortical neurons and the volume conductor. However, the multiplicity of cellular processes with extremely intricate mixtures of deterministic and random factors prevented the creation of consistent biophysical parameter sets. To a [...]