by Shaymaa Azawi  , Lisa-Marie Barf  , Thomas Liehr  , Stefanie Kankel  and Martina Rincic

Received: 25 March 2022;  Published: 27 June 2022;  doi: 10.21926/obm.genet.2202159

After being established in 1967, the commercially available murine Leydig cell tumor line I-10 has been used in almost 50 published studies. I-10 has not been characterized, either at the chromosomal/ cytogenetic level or the genetic level, similar to many other murine tumor cell lines. In this study, we performed molecular karyotyping and multicolor banding-based molecular cytogenetics. A slightly hyperdiploid karyotype with 43 chromosomes was described. The main aberrations comprised several unbalanced translocat [...]

by Irina Udina  , Yurii Vasiliev  , Vladimir Volobuyev  , Olga Gulenko  and Alesya Gracheva

Received: 24 December 2021;  Published: 27 June 2022;  doi: 10.21926/obm.genet.2202158

In this study, we investigated VNTR polymorphisms in intron 2 of the IL1RN gene (rs2234663) and intron 3 of the IL4 gene (rs8179190) related to the development of caries in school children (N = 196) with mixed bite dentition from Krasnodarskii Krai. The genotypes A1/A1 and L/L (L-"long" alleles) (rs2234663) provided resistance to the most intensive form of dental caries. The groups of children with DFC (decompensated form of caries) were significantly different from the pooled group SFC (subcompensated form of cari [...]

by Cherechi Ndukwe  , M. Tariq Iqbal  , Jahangir Khan  and Mohsin Jamil

Received: 18 April 2022;  Published: 26 June 2022;  doi: 10.21926/jept.2202022

One important aspect toward proper and stable functioning of a communication-based controlled microgrid is data transmission. Consequently, an analysis of the effect of data transmission delay is of significance for any chosen communication protocol. This paper focuses on the effect of employing LoRa for data transfer at the secondary control level of a standalone DC microgrid. It analyses the effect of LoRa transmission delay on the dynamic performance of DC microgrids. This paper simulates a community DC microgri [...]

by Irina L. Puppo  , Ziravard N. Tonyan  , Alisa N. Panina  , Ksenia V. Shunkina  , Alsu F. Saifitdinova  , Yulia A. Loginova  , Anna A. Kinunen  , Julia R. Pastuhova  , Olga A. Leonteva  , Olga G. Chiryaeva  , Olga V. Malysheva  , Elena M. Fedorova  , Tatyana V. Vavilova  and Natalia K. Bichevaya

Received: 28 March 2022;  Published: 22 June 2022;  doi: 10.21926/obm.genet.2202157

Robertsonian translocations (RTs) are very common balanced structural chromosome rearrangements in humans. Due to alterations in the chromosome segregation pattern and the formation of unbalanced gametes and embryos, the carriers of RTs have a significant risk of reproductive failure. For over 30 years, fluorescent in situ hybridization (FISH) has been used for preimplantation genetic testing for chromosomal structural rearrangement (PGT-SR) in carriers of RTs. The data obtained by performing FISH for PGT-SR can be [...]

by Jia Yu  , Haiyan Jing  , Zongdeng Wu  , Boyuan Liu  , Wu Lei  and Qingli Hao

Received: 29 April 2022;  Published: 21 June 2022;  doi: 10.21926/cr.2202016

The rational design of efficient electrocatalysts for oxygen reduction reaction (ORR) is the key to developing fuel cells and metal-air batteries. Carbon-supported iron-based materials, as the most promising electrocatalysts for ORR, have drawn much attention as they are cost-effective and exhibit high activity. In this work, a three-dimensional (3D) Fe3O4-decorated N-doped graphene aerogel (Fe3O4/NGA) catalyst was synthesized following a simple hydrothermal method which was followed by an annealing process. The co [...]

by Giuseppe Cocco  and Stefano Pandolfi

Received: 07 February 2022;  Published: 16 June 2022;  doi: 10.21926/obm.geriatr.2202200

Syncope is characterized by a transient and rapid loss of consciousness for a short duration, with full spontaneous recovery within minutes. Syncope causes up to 2% of all emergency medical consultations. The incidence of syncope is similar in men and women, is higher in old patients (slightly higher in old women). The prevalence of syncope is up to 23% for the institutionalized elderly. In elderly patients, syncope often presents atypically, such as with falls; these patients might also have difficulty recalling e [...]

by Chris Fraser  , Paul Dargusch  and Genia Hill

Received: 10 January 2022;  Published: 16 June 2022;  doi: 10.21926/aeer.2202026

The first step in managing an entity's carbon emissions involves measurement as 'what gets measured gets managed' and measurement lies at the heart of carbon management. The study of carbon management is important to all stakeholders as it enables calculation of emissions that can help determine opportunities for emissions reductions to address climate change which can improve energy efficiency and brand reputation. Alphabet is an interesting company to study given its main commercial activities relate to the devel [...]

by Stephan John  , Svenja Rink  , Leandra Weidemann  , Katrin Huesker  and Wilhelm Niedermeier

Received: 21 April 2022;  Published: 15 June 2022;  doi: 10.21926/rpm.2202012

Combining dental ceramics with other prosthetic metallic restorations might release metal ions, thus affecting the oral tissues of the patients. In this study, we evaluated the electrochemical solubility of various dental ceramics in a galvanic experimental setup in vitro. Smooth and rough feldspathic and zirconium dioxide ceramics (at pH 5.5 and pH 3.0) were exposed to an electric field. Calcium, barium, and zirconium were selected as parameters to determine the solubility of both types of ceramic materials. Among [...]

by Jason W. Tate  , Bruce F. O'Hara  and Sainan Wei

Received: 23 April 2022;  Published: 15 June 2022;  doi: 10.21926/obm.genet.2202156

The term chimera refers to an organism with cell lines from two or more distinct zygotes. Human chimerism may occur naturally or artificially. Although rare, advancements in genetics and genomics have resulted in the identification of additional natural human chimeras. Three forms of naturally occurring chimerism have been documented in humans: blood group chimerism, microchimerism, and fusion chimerism. Fusion chimerism may occur through several means. Sex-chromosome discordant chimerism refers to individuals with [...]

by Rie Sasaki  , Hiroto Ito  and Masami Okamoto

Received: 01 March 2022;  Published: 14 June 2022;  doi: 10.21926/obm.genet.2202155

In this study, we examined the effect of a combination of surface topographies (fiber alignments) and different stiffness of poly(L-lactic acid) (PLLA) substrates on the direct relationship between anti-cancer drug (CDDP) sensitivity for MDA-MB-231 cells and mesenchymal properties under both normal and hypoxic conditions. In addition, we studied the induction of epithelial–mesenchymal transition (EMT). The CDDP treatment under hypoxia indicated poor adhesion of MDA-MB-231 cells as well as significant repression of [...]