by Giacinto Libertini

Received: 19 February 2017;  Published: 13 April 2017;  doi: 10.21926/obm.geriatr.1702002

Currently, geriatric medicine consists mainly of palliative treatment of the disorders that characterize senile decay. This is perfectly compatible with the prevailing view that aging is the inevitable result of multiple degenerative processes that cannot be treated effectively as they are, in themselves, inevitable and irreversible. This interpretation of aging clashes with a mass of data and arguments that, conversely, indicate that aging is a specific physiological function, favoured by supra-individual natural [...]

by Michael Fossel

Received: 11 December 2016;  Published: 06 January 2017;  doi: 10.21926/obm.geriatr.1701001

Geriatrics, and much of clinical medicine, is on the verge of a profound transformational shift. Until now, there has been a sharp conceptual divide between diseases which can be readily and effectively treated, and diseases which we have thought to be beyond clinical intervention. In the first disease category, are many of the most common infections that respond to antibiotics and immunizations. We have made dramatic changes in the demographics and the mortality of many such treatable diseases. At the other extrem [...]

by Heba Salman Mahdi Alabayji  and Ahlam Kadhim Naeem

Received: 05 June 2026;  Published: 15 September 2026;  doi: 10.21926/obm.genet.2603358

Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. It is frequently linked to resistance to multiple antibiotic classes and can persist in hospital environments despite infection control measures. This study aimed to evaluate the distribution of antibiotic resistance genes among K. pneumoniae. A total of 38 isolates were obtained from different clinical specimens and identified using the VITEK 2 Compact (GN-ID Card) and PCR targeting 16S rRNA. Multip [...]

by Tekin Ahmet Serel  , Onur Ertunç  , Merve Meryem Kıran  , Esra Şengül  , Zeynep Ruken Hakkoymaz  and Eda Uysal Aydın

Received: 11 February 2026;  Published: 07 September 2026;  doi: 10.21926/obm.genet.2603357

Tumor mutational burden (TMB) is a critical biomarker associated with the response to immunotherapy in prostate cancer. The heterogeneity of tumors can complicate the prediction of TMB, making reliable detection essential for effective treatment planning. Recent advancements in deep learning (DL) have facilitated the analysis of histopathological images, enabling better predictions of TMB. This study utilized the Cancer Genome Atlas (TCGA) cohort of prostate cancer patients, comprising 580 H&E-stained whole slide i [...]

by Md Arif Sakil  , Shagata Islam Shorna  , Maisha Rahman  , Tahmina Akter  , Prodipto Bishnu Angon  , Arpita Rani Roy  and Mohammed Arif Sadik Polash

Received: 07 October 2025;  Published: 04 September 2026;  doi: 10.21926/obm.genet.2603356

Salinity and drought stresses induced by climate change pose critical threats to global food security, necessitating a comprehensive insight of plant adaptive mechanisms at the genomic level. This review brings together recent advances in identifying genes, regulatory networks, and evolutionary strategies underlying plant responses to osmotic stress. We discuss key transcription factor families (DREB, NAC, MYB, and WRKY), ion transporters (SOS pathway, NHX, and HKT), genes involved in osmolyte biosynthesis, and rea [...]

by Alfonso Pellegrino  and Alessandro Stasi

Received: 16 January 2026;  Published: 27 August 2026;  doi: 10.21926/obm.genet.2603355

This bibliometric review analyzes 387 Scopus-indexed publications (1970-2025) on the relationship between genetics and education, retrieved with the query (“Genetics” AND “Academic Performance”) OR (“Heritability” AND “Education”). Research output was minimal until the 2000s, then expanded rapidly with the rise of twin cohorts and, after 2010, large genome-wide association studies (GWAS) and polygenic prediction. Science mapping reveals three thematic clusters: classical heritability studies of cognitive and academ [...]

by Elham Amjad  and Babak Sokouti

Received: 15 December 2025;  Published: 24 August 2026;  doi: 10.21926/obm.genet.2603354

The pathology of PD is characterized by progressive degeneration of dopaminergic neurons, although the full regulatory network involved in this process is not yet fully established. The present research employed a multi-omic systems biology design, integrating transcriptomic, functional, epigenetic, and microRNA analyses to develop a mechanistic model of neurodegeneration in the substantia nigra. We have determined six differentially expressed genes, such as tyrosine hydroxylase (TH), solute carrier family 18 membe [...]

by Maria Bisba  , Eirini Louizou  , Konstantinos Tzanakis  , Thomas Liehr  and Spiros Vittas

Received: 21 January 2026;  Published: 21 August 2026;  doi: 10.21926/obm.genet.2603353

Small supernumerary marker chromosomes (sSMCs) are rare chromosomal abnormalities with diverse outcomes and variable effects that can be detected prenatally. The clinical significance of low-level mosaic sSMCs is often uncertain, and postnatal follow-up is essential to assess phenotypic outcomes. A fetus in whom a low-level mosaic sSMC (8%) was detected during prenatal testing is reported. The sSMC was found in 12 out of 150 metaphases examined by conventional karyotype, followed by molecular cytogenetic analyses ( [...]

by Elisavet Kouvidi  , Georgios Boutsikas  , Marina Kalomiraki  , Maria Devetzoglou  , Foteini Drimaki  , Ioannis Anagnostopoulos  and Evangelia-Faidra Triantafyllou

Received: 31 December 2025;  Published: 17 August 2026;  doi: 10.21926/obm.genet.2603352

The genetic hallmark of Acute promyelocytic leukemia (APL) is the balanced reciprocal translocation t(15;17)(q24;q21), resulting in the PML::RARα fusion gene. Although the majority of APL patients carry the typical t(15;17), variant translocations involving three or more chromosomes have also been described. We report a case of a 59-year-old man showing clinical, morphologic, laboratory, and immunophenotypic findings of APL. Cytogenetic analysis revealed a variant complex 4-point break-three-way translocation invol [...]

by Leena Rawal  and Vamshi Krishna Thamtam

Received: 15 April 2026;  Published: 10 August 2026;  doi: 10.21926/obm.genet.2603351

Acute myeloid leukemia (AML) represents a clinically and genetically heterogeneous group of hematologic malignancies. Among the less frequently encountered cytogenetic abnormalities are jumping translocations (JTs), in which a segment from a donor chromosome relocates to multiple recipient chromosomes. Although uncommon, these events have been described in association with clonal evolution and, in some cases, more aggressive disease behavior. Here, we describe a 49-year-old man who presented with fatigue and genera [...]