by Roberto Anaya-Fernández  , Roberto Anaya-Prado  , Michelle M. Anaya-Fernández  , Miguel A. Guerrero-Palomera  , Ivan F. Garcia-Ramirez  , Daniel Gonzalez-Martinez  , Consuelo C. Azcona-Ramirez  , Citlalli S. Guerrero-Palomera  , Claudia Garcia-Perez  , Bernardo Tenorio-Gonzalez  , Jose E. Tenorio-Gonzalez  , Laisha F. Vargas-Ascencio  , Abraham I. Canseco-Villegas  , Gustavo Servin-Romero  , Allen R. Barragan-Arias  and Bruno Reyna-Rodriguez

Received: 02 May 2024;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403239

Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...]

by Nadia El Kadmiri

Received: 16 August 2023;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403238

The use of immunotherapy as a therapeutic approach to Alzheimer's Disease (AD) is gaining rapid interest, with the primary goal of targeting abnormalities that impact neuronal viability through specific antibodies. Currently, clinical strategies focus intensively on targeting the two main pathologies associated with AD, beta-amyloid (Ab) and tau. This review examines ongoing research in the realm of tau immunotherapy, including clinical trials that demonstrate promising potential for halting AD progression. Several [...]

by Mario Muselli  , Loreta Tobia  , Eleonora Cimino  , Carlo Confalone  , Martina Mancinelli  , Leila Fabiani  , Stefano Necozione  and Vincenza Cofini

Received: 30 March 2024;  Published: 06 August 2024;  doi: 10.21926/obm.neurobiol.2403237

The COVID-19 pandemic has led to unprecedented challenges globally, impacting various aspects of daily life, including education. This study examines the effects of the pandemic on stress levels and substance use among Italian medical students. Two independent surveys were conducted: 388 medical students were interviewed before the epidemic, and 222 medical students a year after the COVID-19 epidemic began. Results revealed significant changes in stress levels, with a reduction in mild stress and an increase in sev [...]

by Danilo Donati  , Giacomo Farì  , Federica Giorgi  , Riccardo Marvulli  , Francesco Quarta  , Andrea Bernetti  and Roberto Tedeschi

Received: 29 May 2024;  Published: 06 August 2024;  doi: 10.21926/obm.neurobiol.2403236

This review examines the efficacy of motor imagery (MI) as a supplementary rehabilitation technique for stroke patients. Nine randomized controlled trials (RCTs) were analyzed, highlighting MI's potential to enhance motor recovery, mobility, balance, and psychological well-being. Significant improvements in upper-limb function were observed with combined mental and physical practice, evidenced by notable gains in Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT) scores. MI-based exercise programs impr [...]

by Catarina F. Martins  , Jorge Soares  and Maria Paula Mota

Received: 20 March 2024;  Published: 01 August 2024;  doi: 10.21926/obm.neurobiol.2403235

Alzheimer's disease is a neurodegenerative condition that impacts an individual's physical, cognitive, and social well-being, ultimately resulting in a decline in independence and functionality. This case report explores how a program combining multimodal physical exercise and psychomotor rehabilitation can improve outcomes in interventions for Alzheimer's disease patients. This approach can enhance treatment effectiveness and provide researchers and practitioners with additional therapeutic options. The participan [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 17 May 2024;  Published: 30 July 2024;  doi: 10.21926/obm.neurobiol.2403234

The COVID-19 pandemic brought different intolerable and uncomfortable situations that ruined the students' academic performance, career opportunities, and social lives through depression, anxiety, fear, uncertainty, and mental illness. In this study, we examined the psychological threats of the COVID-19 among Egypt’s public-sector university students. We employed quantitative methods in this study and used a questionnaire to collect cross-sectional data. The Structural Equation Modeling (SEM) results show that Fear [...]

by Mohadeseh Rajabpour  , Alireza Ala  , Eliyar Sadeghi-Hokmabadi  , Hasan Amiri  , Sara Rostamnezhad  and Samad Shams Vahdati

Received: 07 March 2024;  Published: 19 July 2024;  doi: 10.21926/obm.neurobiol.2403233

Hyperlipidemia is one of the critical risk factors for cerebrovascular disease. Many studies have emphasized that controlling the lipid level can decrease the risk of cardiovascular and cerebrovascular events. In this article, we studied all types of lipids in stroke patients and wanted to consider any relation between lipid level in admission and outcome. This retrospective, cross-sectional study was conducted at Imam Reza Research and Training Hospital. It was performed on a sample of 2165 patients who visited th [...]

by Roberto Anaya-Prado  , Ana P. Cárdenas-Fregoso  , Ana M. Reyes-Perez  , Danielle M. Ortiz-Hernandez  , Montserrat Quijano-Ortiz  , Monica V. Delgado-Martinez  , Ana S. Pelayo-Romo  , Roberto Anaya-Fernández  , Michelle M. Anaya-Fernández  , Consuelo C. Azcona-Ramirez  , Ivan F. Garcia-Ramirez  , Miguel A. Guerrero-Palomera  , Daniel Gonzalez-Martinez  , Citlalli S. Guerrero-Palomera  , Karina Paredes-Paredes  and Claudia Garcia-Perez

Received: 23 February 2024;  Published: 16 July 2024;  doi: 10.21926/obm.neurobiol.2403232

The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and b [...]

by Ioannis Syros  and Xenia Anastassiou-Hadjicharalambous

Received: 19 October 2023;  Published: 15 July 2024;  doi: 10.21926/obm.neurobiol.2403231

Obsessive-Compulsive Disorder (OCD) is a prevalent child and adolescent psychiatric condition characterized by substantial functional impairments. Cognitive Behavioral Therapy (CBT) has emerged as the primary therapeutic approach for managing mild to moderate cases of OCD in children and adolescents. Significant advancements have been made in applying CBT specifically to this age group in the past decade. Exposure and response prevention (ERP) is a core therapeutic technique grounded in the principle that anxiety t [...]

by Sara Alattar  , Muhammad Nouman  , Chidozie Onyiuke  , Conrad Stasieluk  and Edwin Meresh

Received: 29 November 2023;  Published: 05 July 2024;  doi: 10.21926/obm.neurobiol.2403230

Studies have shown that decrease in time intubated is associated with better prognosis. Delirium is associated with increased duration of mechanical ventilation and Intensive Care Unit (ICU) length of stay. However, there is limited report on delirium in intubated seizure patients. As per report, low Glasgow Coma Scale (GCS) increased the risk of delirium and thus increasing ICU length of stay. Information on delirium and outcome in intubated seizure patients receiving lacosamide versus phenytoin is limited. Our re [...]