Table of Content

Open Access Review

Clinical Trials Characterizing the Serum 25-Hydroxyvitamin D Response to Vitamin D Supplementation in Children: A Systematic Review and Meta-Analysis

Received: 13 September 2024;  Published: 29 October 2025;  doi: 10.21926/rpn.2504024

Abstract

Recommendations for vitamin D supplementation are essential for the prevention and therapy of vitamin D deficiency. However, reliable data remain lacking for children, as most intake recommendations are based on individual studies. This work aimed to obtain reliable data that allow health authorities to re-evaluate recommendations for oral vitamin D uptake in children. We conducted a systematic literature search in MEDLINE/PubMed on vitamin D supplementation in children. All randomized controlled trials (RCTs) publ [...]

1162 5541

Open Access Review

Impact of Heavy Metals as Trace Elements on the Ecosystem and Health

Received: 10 June 2025;  Published: 21 October 2025;  doi: 10.21926/rpn.2504023

Abstract

Heavy metals are integral parts of our environment, originating initially from the universe and used in the industry, which may contribute to pollution. This book chapter aims to address the impact of heavy metals on the ecosystem and human health. Among the 32 heavy metals, eight belong to the group of essential ones: cobalt, copper, iron, manganese, molybdenum, nickel, selenium, and zinc. They were necessary in physiological amounts for the evolution of flora and fauna, including humans on earth, and are still ne [...]

1650 12004

Open Access Interview

An Interview with Dr. Blanca Hernandez-Ledesma

Received: 28 August 2025;  Published: 09 October 2025;  doi: 10.21926/rpn.2504022

546 1892

Open Access Review

The Impact of Vitamin D on Type 2 Diabetes Mellitus: Exploring Its Role in Glucose Metabolism and Insulin Sensitivity

Received: 15 May 2025;  Published: 29 September 2025;  doi: 10.21926/rpn.2503021

Abstract

Vitamin D, a fat-soluble secosteroid, plays a pivotal role beyond its functions in calcium and bone homeostasis. Emerging evidence suggests its involvement in glucose metabolism and insulin sensitivity, thus influencing the pathophysiology of Type 2 Diabetes Mellitus (T2DM). For the current review, a search was conducted across four major databases: PubMed, Embase, Google Scholar, and Web of Science. The aim was to identify relevant studies and clinical trials, published in English, reporting the mechanistic insigh [...]

1438 7939

Open Access Original Research

Preliminary Comparative Sodium Analysis of Different Tempeh Types in Indonesia and Its Benefits for Hemodialysis

Received: 01 April 2025;  Published: 19 September 2025;  doi: 10.21926/rpn.2503020

Abstract

Hemodialysis patients require a diet rich in protein that is easily digestible, such as tempeh. Tempeh is a local Indonesian food product that can be purchased at a low price. Tempeh has a low sodium content, but there has never been an analysis related to the difference in sodium content in local Indonesian soybean tempeh products and imported soybean tempeh. This study was to compare the sodium analysis of different tempeh types in Indonesia as a preliminary study for the subsequent research to fulfill a high-pro [...]

727 3568

Open Access Perspective

Therapeutic Carbohydrate Reduction for Lipedema: Guidelines for a Patient-Centered, Holistic Approach

Received: 31 May 2025;  Published: 03 September 2025;  doi: 10.21926/rpn.2503019

Abstract

Lipedema is a chronic, often misdiagnosed disease characterized by painful, disproportionate fat accumulation in the extremities. Commonly mistaken for obesity or lymphedema, lipedema primarily affects women and has long been thought to be resistant to dietary intervention, a belief originating from its initial description by Allen and Hines at the Mayo Clinic in 1940. However, emerging research challenges this notion, revealing that individuals with lipedema often respond positively to therapeutic carbohydrate (CH [...]

3982 32583

Open Access Review

Engaging with an Industrial Pandemic: Drivers of and Responses to the Expansion of Ultra-Processed Foods in East and Southern Africa

Received: 14 January 2025;  Published: 29 August 2025;  doi: 10.21926/rpn.2503018

Abstract

Intensified marketing and expanding consumption of ultra-processed foods (UPFs) that contain high sugar, salt, trans-fats and other additives and sugar sweetened beverages in Sub-Saharan Africa (SSA) are associated with rising obesogenic environments and non-communicable diseases, termed by some an ‘industrial pandemic’ due to its commercial drivers and cross border nature. This review paper addresses the question of how far SSA, positioned at an early point of a rising wave, is controlling this growing health chal [...]

1404 5558

Open Access Interview

An Interview with Prof. Rosita Gabbianelli

Received: 24 August 2025;  Published: 27 August 2025;  doi: 10.21926/rpn.2503017

Abstract

An Interview with Prof. Rosita Gabbianelli

553 2485

Open Access Review

Physiological Impact of Milk on Multiple Health Outcomes in Human

Received: 19 December 2024;  Published: 20 August 2025;  doi: 10.21926/rpn.2503016

Abstract

Milk is best known as a nutrient-rich fluid produced by the mammary glands of mammals, designed primarily to feed young. In the human diet, cow milk is most prevalent, but milk of other mammals and plant milk are common too. This study aims to investigate milk's nutritional value in various age groups and review opposing evidence of its effect on cardiovascular diseases in adults. It is a literature-based strategy to synthesize information from observational and meta-analytic studies. The milk content—macronutrient [...]

2205 11671

Open Access Original Research

Germination-Induced Starch Influence on Structural Characteristics of Water-Soluble Extracts from Purple Pericarp Creole Corn

Received: 14 October 2024;  Published: 28 July 2025;  doi: 10.21926/rpn.2503015

Abstract

Germination is a viable, cost-effective, and environmentally friendly biotechnological process that enhances the industrial applications of cereals. This study evaluated the impact of germination (86 hours at 30°C) on soluble solids, proximate composition, and total phenolic compounds (TPC) in water-soluble extracts. It also included imaging analyses using scanning electron microscopy (SEM), X-ray diffraction (XRD), apparent amylose content, and starch pasting properties of purple pericarp Creole corn (PPCC) fr [...]

1049 4530

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