by Fatima Abbas Nasser Albawi  , Mourouge Saadi Abbas Alwash  and Liqaa Yehya Mohsen

Received: 16 May 2026;  Published: 11 October 2026;  doi: 10.21926/obm.genet.2604363

Multidrug-resistant Pseudomonas aeruginosa is a major cause of hospital-acquired infections and is responsible for high mortality rates due to its intrinsic and acquired resistance mechanisms to various antibiotics. This study aimed to investigate the prevalence of the AmpC beta-lactamase enzyme and the MexAB-OprM efflux pump genes, as well as the effect of the inhibitors cloxacillin and Phe-Arg β-naphthylamide dihydrochloride (PAβN) on its antibiotic resistance. The current cross-sectional study included 227 P. ae [...]

by Hamed Haghparast Mojdehi  , Niloofar Faraji  and Hadi Habibollahi

Received: 25 August 2026;  Published: 08 October 2026;  doi: 10.21926/obm.genet.2604362

Pancreatic cancer is a highly aggressive and therapy-resistant malignancy. This study evaluated the cytotoxic effects of Syzygium aromaticum (clove) aqueous extract on PANC-1 pancreatic cancer cells and its effect on TP53 mRNA expression. PANC-1 cells were exposed to increasing concentrations of the extract (10-1000 μg/ml) for 48 h. We assessed cell viability using the MTT assay and calculated the half-maximal inhibitory concentration (IC50) using four-parameter logistic regression. TP53 mRNA expression was quantif [...]

by Aishwarya Rani  , Shalesh Gangwar  , Neha Sharma  , Khalid Raza  , Sameer Gupta  and Devinder Toor

Received: 15 June 2026;  Published: 05 October 2026;  doi: 10.21926/obm.genet.2604361

Fetuin-A, encoded by the AHSG gene, is a hepatokine that regulates metabolism, ectopic calcification, and cardiovascular homeostasis. Beyond mineral sequestration, it binds Bone Morphogenetic Protein (BMP) ligands, modulating their extracellular availability. BMP-10 supports endothelial integrity, vascular remodeling, and signaling through BMP receptor type 2 (BMPR2). Impaired BMP-10 signaling is linked to cardiovascular diseases (CVDs). Non-synonymous single-nucleotide polymorphisms (nsSNPs) in AHSG can alter fetu [...]

by Samaa Asaad Hameed  , Thikra Adnan Jawad Banimusleum  and Zahraa Isam Jameel

Received: 02 June 2026;  Published: 28 September 2026;  doi: 10.21926/obm.genet.2603360

Sepsis has a complex genetic background; many genes may directly or indirectly affects its development. Since cytokines control the type, severity, and consequences of pathogenesis, they are also involved in some aspects of sepsis. This research aims to investigate the relationship between IL-6 gene polymorphism and sepsis. For this research, a total of 75 patients with sepsis disease and another 75 individuals without the disease were taken as the controls for this genetic study. The IL-6 gene has many high-freque [...]

by Syahrul Tuba  , Luluk Sakdiyyah  , Natanael Panjaitan  , F. Josse Pasca Pradana  , Adi Priyono  and Budi Sumaryono

Received: 16 December 2025;  Published: 21 September 2026;  doi: 10.21926/obm.genet.2603359

Tamoxifen remains a cornerstone in the treatment of estrogen receptor-positive (ER+) breast cancer; however, variability in patient response underscores the necessity of a pharmacogenomic approach. This review integrates germline and somatic pharmacogenomics to elucidate the molecular determinants of tamoxifen metabolism, efficacy, and resistance. Germline polymorphisms, particularly in CYP2D6, CYP3A4/5, UGT2B7, and SULT1A1, significantly influence endoxifen levels, driving therapeutic variability across ethnic pop [...]

by Heba Salman Mahdi Alabayji  and Ahlam Kadhim Naeem

Received: 05 June 2026;  Published: 15 September 2026;  doi: 10.21926/obm.genet.2603358

Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. It is frequently linked to resistance to multiple antibiotic classes and can persist in hospital environments despite infection control measures. This study aimed to evaluate the distribution of antibiotic resistance genes among K. pneumoniae. A total of 38 isolates were obtained from different clinical specimens and identified using the VITEK 2 Compact (GN-ID Card) and PCR targeting 16S rRNA. Multip [...]

by Tekin Ahmet Serel  , Onur Ertunç  , Merve Meryem Kıran  , Esra Şengül  , Zeynep Ruken Hakkoymaz  and Eda Uysal Aydın

Received: 11 February 2026;  Published: 07 September 2026;  doi: 10.21926/obm.genet.2603357

Tumor mutational burden (TMB) is a critical biomarker associated with the response to immunotherapy in prostate cancer. The heterogeneity of tumors can complicate the prediction of TMB, making reliable detection essential for effective treatment planning. Recent advancements in deep learning (DL) have facilitated the analysis of histopathological images, enabling better predictions of TMB. This study utilized the Cancer Genome Atlas (TCGA) cohort of prostate cancer patients, comprising 580 H&E-stained whole slide i [...]

by Md Arif Sakil  , Shagata Islam Shorna  , Maisha Rahman  , Tahmina Akter  , Prodipto Bishnu Angon  , Arpita Rani Roy  and Mohammed Arif Sadik Polash

Received: 07 October 2025;  Published: 04 September 2026;  doi: 10.21926/obm.genet.2603356

Salinity and drought stresses induced by climate change pose critical threats to global food security, necessitating a comprehensive insight of plant adaptive mechanisms at the genomic level. This review brings together recent advances in identifying genes, regulatory networks, and evolutionary strategies underlying plant responses to osmotic stress. We discuss key transcription factor families (DREB, NAC, MYB, and WRKY), ion transporters (SOS pathway, NHX, and HKT), genes involved in osmolyte biosynthesis, and rea [...]

by Alfonso Pellegrino  and Alessandro Stasi

Received: 16 January 2026;  Published: 27 August 2026;  doi: 10.21926/obm.genet.2603355

This bibliometric review analyzes 387 Scopus-indexed publications (1970-2025) on the relationship between genetics and education, retrieved with the query (“Genetics” AND “Academic Performance”) OR (“Heritability” AND “Education”). Research output was minimal until the 2000s, then expanded rapidly with the rise of twin cohorts and, after 2010, large genome-wide association studies (GWAS) and polygenic prediction. Science mapping reveals three thematic clusters: classical heritability studies of cognitive and academ [...]

by Elham Amjad  and Babak Sokouti

Received: 15 December 2025;  Published: 24 August 2026;  doi: 10.21926/obm.genet.2603354

The pathology of PD is characterized by progressive degeneration of dopaminergic neurons, although the full regulatory network involved in this process is not yet fully established. The present research employed a multi-omic systems biology design, integrating transcriptomic, functional, epigenetic, and microRNA analyses to develop a mechanistic model of neurodegeneration in the substantia nigra. We have determined six differentially expressed genes, such as tyrosine hydroxylase (TH), solute carrier family 18 membe [...]