by Taslim Uddin  , Fatema Tuz Zohora  , Tajmin Khanam  , Moumita Akter  , Lubaba Ibnul Himika  , Anika Tabassum Aziz  , Fariha Tabassum  , Syeda Marjia Kajol Tushy  , Salaha Aktar  , Maisha Maliha Misha  , Shaikh Nuzhat Nawshin Nimu  , Sadia Tasnim  , Shammi Akter Joya  , Israt Tasnim Mahisa  and Shahrin Akter Pinky

Received: 09 January 2026;  Published: 15 April 2026;  doi: 10.21926/obm.genet.2602337

Changes in the environment driven by climate change are becoming significant stressors that impact brain function, but the connections between these changes and neural plasticity remain unclear. This review aims to offer a comprehensive synthesis of the impact of climate-related stressors on neural plasticity via genetic and epigenetic mechanisms. A structured literature search (2000-2025) was conducted using PubMed, Scopus, and Web of Science, integrating evidence from in vitro, animal, and human studies. Findings [...]

by Elham Alimoradi  , Parham Nejati  , Fatemeh Molavi  , Setareh Isaee  , Soudeh Ghafouri-Fard  and Reza Alibakhshi

Received: 25 November 2025;  Published: 13 April 2026;  doi: 10.21926/obm.genet.2602336

Sensorineural hearing loss (SNHL) describes a diverse group of clinically and genetically distinct disorders of the auditory system. SNHL is associated with mutations in up to 150 genes. Among them is Cadherin 23 (CDH23), which is associated with both Usher syndrome and non-syndromic hearing loss. In the current study, we used WES to find the genetic cause of SNHL in an extended Iranian family. WES and subsequent Sanger sequencing confirmed the occurrence of a novel homozygote variant in the CDH23 gene (c.817T>C, p [...]

by Anastasiia Kornutii  , Oleksandr Kornutii  , Ivanna Shymanska  , Maiia Bondarenko  and Natalia Prokopchuk

Received: 12 September 2025;  Published: 13 April 2026;  doi: 10.21926/obm.genet.2602335

Craniosynostosis is a disorder characterized by premature closure of cranial sutures, resulting in restricted skull growth perpendicular to the affected suture and compensatory growth in other directions. Over 180 syndromes have been classified under craniosynostosis, of which eight are associated with mutations in the fibroblast growth factor receptor 2 (FGFR2) gene: isolated coronal synostosis, Pfeiffer syndrome, Crouzon syndrome, Apert syndrome, Beare–Stevens syndrome, Jackson–Weiss syndrome, Crouzon syndrome wi [...]

by Thu-Thao Thi Huynh  , Thi Nga Nguyen  , Anh-Duy Hoang Nguyen  and Minh Trong Quang

Received: 15 January 2026;  Published: 07 April 2026;  doi: 10.21926/obm.genet.2602334

Rauvolfia tetraphylla L. (1753) is an important medicinal species of Apocynaceae, widely used for its rich indole alkaloids and related bioactive compounds. We report the first complete chloroplast genome of R. tetraphylla. The genome exhibits a typical circular quadripartite structure of 155,667 bp, with an overall GC content of 37.8%. The genome comprises a large single-copy (LSC) region of 86,332 bp, a small single-copy (SSC) region of 17,853 bp, and a pair of inverted repeat (IR) regions of 25,741 bp each. A to [...]

by Lyubov Starodub  , Nataliia Mokhnachova  and Ostap Zhukorskyi

Received: 01 December 2025;  Published: 01 April 2026;  doi: 10.21926/obm.genet.2602333

The article reveals the variability of the genome of cattle of the local small-numbered domestic Brown Carpathian breed using cytogenetic and molecular genetic polylocus markers, and justifies the need to integrate local breeds into the modern system of agricultural production in accordance with FAO requirements. The work aimed to study the genetic uniqueness of cows of the brown Carpathian breed using cytogenetic and molecular genetic markers. The karyotype of the animals corresponded to the species norm and was 2 [...]

by Thomas Liehr

Received: 21 January 2026;  Published: 26 March 2026;  doi: 10.21926/obm.genet.2601332

Non-invasive prenatal testing (NIPT) is now standard in prenatal care in many countries, even though it was introduced only about 15 years ago. Due to its rapid adoption into decades-old prenatal care plans, gynecologists, obstetricians, and the general public still struggle to understand the possibilities, benefits, and limitations of NIPT. The biggest challenge facing NIPT is that comprehensive training for healthcare professionals and independent, unbiased information for pregnant women and their families about [...]

by Alžbeta Jauschová  , Jana Žiarovská  and Lenka Kučerová

Received: 26 December 2025;  Published: 23 March 2026;  doi: 10.21926/obm.genet.2601331

Genetically conditioned variation in pollen has been demonstrated to have a substantial influence on reproductive mechanisms and population dynamics. The present study evaluated the genetic variability of 28 pollen samples of Corylus avellana L. using iPBS (Inter Primer Binding Sites Polymorphism) markers 1882 and 2152. The collection of biological material was undertaken at various locations across five European countries, with the objective of capturing a broad spectrum of environmental conditions. The genetic re [...]

by Doaa Mokhtar  , Amina Abdel-Hamid  , Ahmed Mohamed Mostafa  , Ahmed M.S. Elfanah  , Mohamed A Badawi  , Abdullah A. Saber  , Hoda S. Barakat  and Sara Aly

Received: 23 November 2025;  Published: 20 March 2026;  doi: 10.21926/obm.genet.2601330

Salinity poses a danger to food security; hence, it is necessary to create crop types that can withstand salt to meet the growing demand for food. The goal of the current study was to examine the morphological and biochemical responses of wheat (Triticum aestivum L.) genotypes under salt stress. Salt tolerance in ten wheat cultivars and five selected F1 hybrids was assessed at the germination and seedling stage. Genotypes were assessed for seven traits under control (0 mM NaCl) and salinity stress (150, 200, and 25 [...]

by Ahmad M. Khalil

Received: 27 November 2025;  Published: 17 March 2026;  doi: 10.21926/obm.genet.2601329

Diabetes mellitus (DM) is a metabolic disorder resulting from aberrations in insulin secretion or action. Diabetes mellitus still presents as a global health challenge. Conventional diabetes treatment may result in unwanted side effects and/or poor compliance. More personalized and curative approaches to the treatment of DM are required. The review explores recent developments in the fields of genetic and molecular underpinnings of DM, focusing on the revolutionary potential of cell- and Clustered Regularly Intersp [...]

by Noora A. Hadi  , Rehab S. Ramadhan  , Khalid Suhail A. AlAzzawi  , Rebah N. Algafari  , Sura S. Talib  and Rawaa A. Khalaf

Received: 06 December 2025;  Published: 15 March 2026;  doi: 10.21926/obm.genet.2601328

Diabetes mellitus (DM) is widely spread among populations. About 3 of 10 people show the symptoms of this disease. Many factors may cause this illness in both types (type 1 and type 2 DM), mainly attributed to insufficient insulin production in type 1 DM or developing insulin resistance in type 2 DM. Genes that control specific biochemical pathways involving glucose metabolism can interfere with the manifestation of this disease when they undergo genetic changes like KRAS. Investigating the role of KRAS in DM. Abou [...]