by Anastasia Doroshenko  , Matthias Reimers  , Gary Sawers  and Gerald Schlaf

Received: 23 April 2026;  Published: 22 September 2026;  doi: 10.21926/obm.transplant.2603277

Donor-specific antibodies (DSA) directed against human leukocyte antigens (HLA) are regarded as the principal cause of graft failure, including allograft loss. Especially cytotoxic, i.e., complement-fixing, antibodies have long been classified as clinically highly deleterious in the context of graft failure. The complement-dependent cytotoxicity assay (CDC), performed in cell-tray analyses, has been used to define these antibodies for more than 40 years, but generally lacks sensitivity. Due to i [...]

by Elham Amjad  and Babak Sokouti

Received: 11 August 2025;  Published: 14 September 2026;  doi: 10.21926/obm.transplant.2603276

After liver transplantation, colorectal cancer (CRC) recurrence is a serious clinical issue. This underscores the need to understand the molecular and immunometabolic axes that promote tumor development and transplant fragility. This research combines compound-gene network analysis, immune cell deconvolution, and transcriptome profiling to find important genes and pathways that connect post-transplant immune modulation and CRC development. ADH1B, ALB, and ZG16 are consistently altered in primary [...]

by Kathryn L White  , Carol Crochet  and Maheswaran Pitchaimuthu

Received: 09 April 2026;  Published: 11 September 2026;  doi: 10.21926/obm.transplant.2603275

Outcomes in liver transplantation remain constrained by challenges in donor selection, organ allocation, and long-term graft survival, and traditional scoring systems such as MELD, SOFT, and the Donor Risk Index have well-recognized limitations in capturing the nonlinear complexity of transplant data. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), offers analytical methods capable of processing high-dimensional data beyond conventional regression, but the m [...]

by Aqshal Radiva Eryadana  , Eriawan Agung Nugroho  , Muhammad Kemal Thariq Ibrahim  , Pande Made Wisnu Tirtayasa  , Ardy Santosa  , Mohamad Adi Soedarso  , Nanda Daniswara  , Sofyan Rais Addin  , Dimas Sindhu Wibisono  , Fandy Wicaksono  and Donny Austine Wibisisono

Received: 24 May 2026;  Published: 25 August 2026;  doi: 10.21926/obm.transplant.2603274

Multiple renal arteries in living-donor kidney transplantation create technical challenges, but their effect on clinical outcomes is unclear. This review assessed whether grafts with multiple renal arteries differ in short-term outcomes compared with single renal artery grafts. Following PRISMA 2020 guidelines and PROSPERO registration, a systematic search of PubMed, Embase, Scopus, Web of Science, and Cochrane CENTRAL was conducted from database inception until 31 October 2025. Studies publishe [...]

by Affan Faisal  , Zain Tariq  , Harshini Maheswaran  and Maheswaran Pitchaimuthu

Received: 23 April 2026;  Published: 17 August 2026;  doi: 10.21926/obm.transplant.2603273

Liver transplantation is the definitive treatment for end-stage liver disease, acute liver failure, and selected hepatic malignancies, but its success is limited by a persistent shortage of suitable donor organs. This has driven increased use of extended criteria donors (ECDs), including steatotic and donation after circulatory death (DCD) grafts, which are more susceptible to preservation injury and often inadequately supported by traditional static cold storage (SCS). Machine perfusion (MP) ha [...]

by Vikash Chandra Mishra  , Dinesh Chandra  and Vimarsh Raina

Received: 24 March 2026;  Published: 30 July 2026;  doi: 10.21926/obm.transplant.2603272

Hematopoietic stem cell transplantation (HSCT) offers a potentially curative option for a range of malignant and non-malignant hematological disorders. However, only approximately 25-30% of patients have access to a human leukocyte antigen (HLA)-matched related donor (MRD), necessitating alternative donor approaches, including matched unrelated donor (MUD) and haploidentical transplantation. Although advances in haploidentical HSCT have substantially improved donor availability, MUD HSCT continu [...]