Development of New Macroencapsulating Planar Devices to Inhibit Allorejection of Islet Transformed Cells
by
Douglas O. Sobel
and
Keerat Parmar
Douglas O. Sobel
and
Keerat Parmar
Abstract
Subcutaneous transplantation of islets into small-pore macroencapsulation devices that prevent immune cell passage can inhibit allorejection in rodents. However, there are no reports of euglycemia in humans using this technology. This report further develops these macroencapsulation devices. We compared the ability of macroencapsulation transplant devices containing transformed mouse islet cells (MIN-6) with varying polymer membranes, pore sizes, and hydrophilicity to inhibit allorejection and m [...]