Open Access Review

Advances Toward In Vivo Cartilage Repair: A Comprehensive Review of Current Strategies and Future Directions

Received: 03 December 2025;  Published: 07 April 2026;  doi: 10.21926/rpm.2602003

Abstract

The cartilage is avascular and has limited regenerative capacity, posing a significant clinical challenge. Conventional treatments often do not restore hyaline cartilage, leading to progressive osteoarthritis. Recent advances in tissue engineering have focused on integrating biomaterials, stem cells, growth factors, and gene-delivery approaches. In addition, in vivo models serve as critical platforms for translational validation. Biomaterial scaffolds, including polycaprolac [...]