Special Issue

tRNA Modifications in Neuro-Oncology: Epitranscriptomic Regulation of Brain Tumors, Neural Stem Cells, and Therapeutic Resistance

Submission Deadline: July 31, 2027 (Open) Submit Now

Guest Editor

Muhammad Alaa Eldeen, PhD

1. Research Professor, Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02453, Republic of Korea
2. Founder & Academic Director, Division of Computational Genomics and Precision Medicine, EdigenomiX Research Academy, EdigenomiX Scientific Ltd., Zagazig, Sharqia Governorate 44519, Egypt

Website1 | Website2 | E-Mail

Research Interests: Cancer multi-omics; computational oncology; precision medicine; bioinformatics; systems biology; functional genomics; cancer stem cells; cellular senescence; translational oncology; aging biology

About This Topic

Transfer RNA (tRNA) modifications have emerged as a fundamental layer of epitranscriptomic regulation governing translational efficiency, cellular plasticity, stress adaptation, and gene expression programs. Recent studies have demonstrated that dysregulation of tRNA-modifying enzymes contributes to tumorigenesis, cancer stemness, metabolic reprogramming, and therapeutic resistance. Although these mechanisms have been extensively investigated in several malignancies, their implications in neuro-oncology and nervous system tumors remain incompletely understood. Brain tumors, particularly glioblastoma and diffuse gliomas, exhibit profound translational and epitranscriptomic alterations that support tumor progression, invasion, and resistance to treatment. Emerging evidence suggests that tRNA modifications regulate neural stem cell maintenance, tumor stemness, tumor–neuron interactions, and adaptive responses to hypoxia and therapeutic stress within the central nervous system microenvironment.

This Special Issue aims to provide a dedicated platform for original research and comprehensive reviews addressing the mechanistic, translational, and clinical significance of tRNA modifications in neuro-oncology. By integrating molecular neurobiology, epitranscriptomics, cancer biology, and translational neuroscience, the issue seeks to advance our understanding of RNA-based regulatory networks in brain tumors and identify novel diagnostic and therapeutic opportunities.

Topics of Interest

• tRNA modification enzymes in CNS tumors
• METTL1/WDR4 signaling in neuro-oncology
• NSUN family proteins and brain tumor progression
• Epitranscriptomic regulation of glioblastoma
• Neural stem cells and cancer stem cell biology
• Translational reprogramming in nervous system tumors
• Codon usage and translational control in gliomas
• Tumor–neuron interactions
• Brain tumor microenvironment remodeling
• Hypoxia-induced RNA modification pathways
• tRNA-derived fragments as diagnostic biomarkers
• Multi-omics approaches in neuro-oncology
• AI-assisted analysis of epitranscriptomic datasets
• Therapeutic targeting of RNA modification pathways
• Drug resistance and adaptive translational responses

Keywords

tRNA modifications; epitranscriptomics; neuro-Oncology; glioblastoma; glioma; brain tumors; neural stem cells; cancer stem cells; RNA modifications; translational control; tumor microenvironment; therapeutic resistance; biomarkers; tRNA-derived fragments; precision oncology

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (neurobiology@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

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