Migraine as a Common Extra-Intestinal Presentation of Celiac Disease
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Gluten-Related Neurological Disorders
Submission Deadline: June 30, 2020 (Open) Submit Now
Luis Rodrigo, Ph.D
Professor, Gastroenterology Service, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain
Research Interests: Colon Cancer; Hepatocellular Carcinoma; Hepatocellular carcinoma; Liver Cirrhosis; Celiac Disease; Autoimmune related diseases; Neurologic Diseases Gluten-related; Rheumatologic diseases; Sepsis; Infectious Diseases
About This Topic
Celiac disease (CD) has been associated several decades ago, with several neurologic disorders including the cerebellar ataxia, the multiple peripheral neuropathy, some forms of epilepsy and of depression. Recent studies have shown that a great variety of nurologic syndromes and diseases may be associated not only with CD, but also with a minor form of presentation of gluten intolerance known as “Non-celiac gluten sensitivity” (NCGS) that shows a similar clinical manifestations, but the serologic, genetic and histologic markers characteristic of CD, may be absent. The list of neurologic diseases related to CD and also to NCGS has been grown in the last years including the migraines, chorea, mononeuritis, Guillain-Barre-like síndrome, Tourette´s syndrome and others…
It remains unclear if the pathogenesis of the great part of these neurologic diseases must be related directly to the gluten toxicity or through some immonologic mechanisms. But in a great part of clinical neurologic cases, without an efficient therapy, a trial of a gluten-free diet (GFD) during at least one year merits to be proved.
In this special edition, we invite submissions that show case new, inventive and original approaches to longstanding issues in CD and NCGS assessment, treatment and research. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to this topic. All accepted papers will be published free of charge.
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Migraine as a Common Extra-Intestinal Presentation of Celiac Disease
by Maurizio Gabrielli , Veronica Ojetti , Marcello Candelli , Luca Santarelli , Antonio Gasbarrini and Francesco Franceschi
Received: 18 August 2020; Published: 09 February 2021; doi: 10.21926/obm.neurobiol.2101087
Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit [...]
Celiac Disease and Associated Extraintestinal Manifestations, with Special Reference to Neurological Disorders
by Luis Rodrigo
Received: 13 July 2020; Published: 30 October 2020; doi: 10.21926/obm.neurobiol.2004074
Celiac disease (CD), also known as gluten-sensitive enteropathy and nontropical sprue, is one of the most important entities of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestations can be present either at the onset of CD, or appear during the development of the pathology, and the neurologic [...]
A Case of Coincidental Association of Amyotrophic Lateral Sclerosis in a Patient with Celiac Disease Consuming a Gluten-Free Diet
by Edda Cava , Alessandro Collo , Marcella Serioli and Sergio Riso
Received: 30 June 2020; Published: 12 October 2020; doi: 10.21926/obm.neurobiol.2004073
We report, for the first time, the case of amyotrophic lateral sclerosis (ALS) onset in a 54-year-old woman not following a strict gluten-free diet (GFD) for six years after the diagnosis of celiac disease (CD). The patient did not display any sign of gluten toxicity, malabsorption, or CD-related comorbidity. Previous cases reported in medical [...]
Behavioral Disorders and Celiac Disease: Coincidence or Casualty?
Received: 10 May 2020; Published: 24 July 2020; doi: 10.21926/obm.neurobiol.2003067
This paper presents the case of a child diagnosed with both celiac disease and Asperger’s syndrome. The literature does not report this association to date, and the authors believe it to be a coincidence rather than a casualty.
Neurological Manifestations of the Celiac Disease in Children
Received: 07 May 2020; Published: 17 July 2020; doi: 10.21926/obm.neurobiol.2003066
Gluten-related disorders (GRDs) represent a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. The most common and widely recognized diseases within this spectrum are celiac disease and non-celiac gluten sensitivity. The clinical manifestations are intestinal, but extraintes [...]
Neurological Manifestations of Celiac Disease and Non-Celiac Gluten Sensitivity and the Effect of a Gluten Free Diet
by Jamie Zhen and M Ines Pinto-Sanchez
Received: 17 May 2020; Published: 10 July 2020; doi: 10.21926/obm.neurobiol.2003065
Celiac disease (CeD) is an immune-mediated enteropathy triggered by gluten ingestion and affects nearly 1% of the population worldwide. CeD has typically been associated with gastrointestinal symptoms such as diarrhea and abdominal pain; however, its extra-intestinal manifestations are becoming widely recognized. In particular, CeD patients [...]
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