OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 7.6 days from acceptance to publication (median values for papers published in this journal in 2020, 1-2 days of FREE language polishing time is also included in this period).

Current Issue: 2021  Archive: 2020 2019 2018 2017

Special Issue

Deep Brain Stimulation for Neurobiology Diseases

Submission Deadline: December 31, 2020 (Open) Submit Now

Guest Editor

Lilach Soreq, PhD

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK

Website | E-Mail

Research Interests: Gene Expression; Neuroscience; Molecular Biology; Neurodegenerative Diseases; Bioinformatics and Computational Biology

About This Topic

Parkinson’s disease (PD) is an age related devastative neurodegenerative disease. Upon diagnosis almost all the dopaminergic neurons in the brain are already diminished. Deep Brain stimulation (DBS) treatment significantly elevates the disease symptoms including tremor. Recently RNA expression profiles were characterized in PD blood leukocytes prior to and following DBS including both microRNAs and long non coding RNAs through exon and junction microarrays as well as RNA sequencing. Computational analyses revealed significantly changes genes as well as altered molecular pathways. Hierarchical classification allows classification of detected genes by expression levels. The changes included neuro-inflammatory and alternative splicing changes. Non parametric statistics allow identification of further altered gene ontology pathways. Finally, comparison to MPTP treated PD mice models revealed further common changes including in ion channels.

Submission

Manuscripts should be submitted online at http://www.lidsen.com/account-login by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. Guidelines for authors and other relevant information for submission of manuscripts are available on the Instructions for Authors page. OBM Neurobiology is an international peer-reviewed Open Access monthly journal published by LIDSEN. Please visit the Instructions for Authors page before submitting a manuscript.

Planned Papers

Title: Electrophysiological properties of posteromedial hypothalamus
Authors: Lorena Vega-Zelaya 1, Elena Martín-Abad 2, Cristina V. Torres 3, Marta Navas 4 and Jesús Pastor 5, *
Abstract: Pathological aggressiveness is an invalidating condition that can be successfully treated by deep brain stimulation (DBS) at posteromedial hypothalamus (PMH). Although some reports are published about electrophysiological properties of this nucleus, a systematic and comprehensive description lacks. We plan to analyze the electrophysiological properties of PMH and surrounded structures of patients treated by DBS and targeted by microelectrode recording (MER) and neurophysiological testing along the trajectories. The optimal target for SBS is defined by the response to electrical stimulation (Hernando et al, 2008). The aim of our study will be to characterize the neurophysiological properties of PMH, namely, the properties of the action potential morphology, mean frequency of the discharge, density of the neurons, and tonic and phasic properties of the discharge (Vega-Zelaya et al, 2019) in well-defined placed along trajectories defined by the clinical response to electrical stimulation.

Publication

Open Access Review

A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects

Received: 05 February 2021;  Published: 19 May 2021;  doi: 10.21926/obm.neurobiol.2102097

Abstract

Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD b [...]
Open Access Review

Computational Modelling of Deep Brain Stimulation for Parkinson's Disease: A Critical Review

Received: 23 November 2020;  Published: 14 May 2021;  doi: 10.21926/obm.neurobiol.2102095

Abstract

We review the use of numerical and computational models to explore deep brain stimulation for Parkinson’s disease (DBS PD). It is a review for the modeler and those interested in PD DBS modelling methods and their value. The main model categories of active fiber, mean field, driving force, and volum [...]
Open Access Communication

Medical Hypothesis: Deep Brain Stimulation for Intractable Migraine

Received: 26 October 2020;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101082

Abstract

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. D [...]
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