(ISSN 2573-4407)
OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).
OBM Neurobiology publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 7.5 weeks; Submission to Acceptance: 15.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)
Special Issue
Evaluating the Effects of Natural Products on Cellular and Molecular Signaling Pathways for the Management of Neurodegenerative Diseases
Submission Deadline: September 15, 2024 (Open) Submit Now
Guest Editors
Dr. Shoib Ahmad Baba, PhD, Lecturer
Department of Education, Government of Jammu and Kashmir
Research Interests: Natural products; Bioactivity; Antioxidant; Anti-inflammatory; Anti-apoptotic; Neurodegeneration; Signaling pathways; Phytochemicals
Tomohiro Chiba, MD, PhD
Assistant Professor, Department of Pathology, Kyorin University School of Medicine, Tokyo 181-8611, Japan
Research Interests: neurodegenerative diseases; Alzheimer's disease; ALS; Parkinson's disease; neuropathology; neuropharmacology; intracellular signaling pathways; neuro-oncology; CNS malignancy
About This Topic
Neurodegenerative diseases, a heterogeneous group of diseases, are among the serious health issues that affect millions of people across the globe. The incidence of these diseases has significantly increased throughout the world, and it is believed that the risk of developing a neurodegenerative disease increases with age. Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease are the most common neurodegenerative diseases and are accompanied by cerebral cortical atrophy, neuronal loss, protein accumulation, and excessive accumulation of metal ions. In recent years, natural products of plant, animal, or fungal origin have been intensively explored and studied for their protective effects against neurodegenerative diseases. Natural products have the remarkable potential to improve cerebral circulatory disorders, promote cerebral hemostasis absorption, repair damaged nerve tissue, and improve damaged nerve function. Recently, studies have revealed that neuroinflammatory mechanisms and signaling pathways closely related to the occurrence, development, and progression of neurological diseases include microglial activation, the nuclear factor-κB (NF-κB) pathway, the mitogen activated protein kinases (MAPK) pathway, the reactive oxygen pathway, nucleotide binding oligomerization domain-like receptor protein3 (NLRP3) inflammasomes, the toll-like receptor4 (TLR4) pathway, the nuclear factor erythroid 2-related factor 2 (Nrf2)/hemeoxygenase-1 (HO-1) pathway, the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, and intestinal flora. Many studies have shown that natural products can modulate these signaling pathways. Furthermore, they have been recognized to possess diverse biological activities such as antioxidant, anti-inflammatory, and anti-apoptotic. Thus, they exhibit the potential to be used for the management of neurodegenerative diseases.
The aim of this special issue is to gather papers that further our understanding of the role of natural products in regulating molecular and cellular signaling pathways involved in the development of neurodegenerative diseases.
We welcome original research papers and reviews that cover topics including:
- Clinical or preclinical evaluation of natural products in the treatment of neurodegenerative diseases.
- Effects of natural products on signaling pathways involved in neurodegeneration, such as the nuclear factor-κB (NF-κB) pathway, the mitogen-activated protein kinases (MAPK) pathway, and other related pathways.
- Effect of natural products on oxidative stress in neurodegeneration.
- Effect of natural products on modulating autophagy and proteasome activity to prevent abnormal protein aggregation in neurodegenerative diseases.
- Natural products as lead compounds in drug discovery for the management of neurodegenerative diseases.
- Network pharmacology in the identification of target neurodegenerative cellular and molecular signaling pathways of phytochemicals.
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (neurobiology@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
Welcome your submission!
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Vidhi is a Clinical yoga therapist; mentor for yoga therapy training in Krishnamacharya tradition. She holds a MSc in Public health from Kings College London.
Mirela Olympia Fagarasan Palmer
Luigi Fontana, MD, PhD.jpg)
Zhong-Ting (Justin) is a PhD student from Nanyang Technological University (Singapore). He holds BSc in Applied Chemistry and MSc in Environmental Engineering. He was a R&D researcher of NanoMaterials Technology Pte Ltd in Singapore (2006-2012). His current research interests are functional nanomaterials synthesis & design, and their application into environmental/chemical engineering. He has published near 60 SCI papers in Applied Catalysis B, Chemical Engineering Journal and so on with H-Index 23. He also serviced as reviewers over 40 Journals such as Appl. Catal. B, Water Research, Chem. Eng. J, ACS Applied Materials & Interface, etc. He was honored such as “The Bsic Research Achievment 1st Award of CIESC”, “The ZJUT Fund Breeding Distinguished Young Scholars” etc.
Rolf Teschke studied Medicine in Munich and Marburg, where he finished his MD thesis before starting a residency at the Department of Pathology, University of Marburg. Subsequently and with a fellowship of the Deutsche Forschungsgmeinschaft, he worked at the Bronx VA Hospital/Mount Sinai Hospital in New York during 1972–1975 together with Professor Charles S. Lieber and successfully isolated MEOS and expanded its characterization. Back in Germany, he was at the Heinrich-Heine University in Düsseldorf with a focus on alcoholic liver disease, biochemical drug studies, and clinical intoxications by halogenated aliphatic hydrocarbons, where he became a Professor of Medicine. In 1987, he was offered a chief position and appointed as Director of the Medical Department II, City Hospital Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt/Main. His clinical and research interests are on liver injury by drugs and herbs including causality assessment by RUCAM in close association with Dr. Gaby Danan in Paris. A perfect cooperation exists also with Professor Tran Dang Xuan of the University of Hiroshima, Japan. Finally, he is the author of more than 275 publications including books and book chapters, and he is editor in chief of scientific journals and member of editorial boards.