Table of Contents

Open Access

ISSN 2573-4407

OBM Neurobiology , Volume 6 , Issue 1 (2022)

Pages: 62

Published: April 2022

(This book is a printed edition that was published in OBM Neurobiology )

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Cover story:The aim of this research is further expanding upon the proposed link between arterial stiffness and several pathogenic processes (cardiovascular risks, pulse pressure, late-onset dementia, Alzheimer's disease, and aging) -- as well as to mention implications for therapeutic drug targeting. A therapeutic strategy to delay late-onset dementia could be based upon localized drug delivery, using lipid nanocarriers (i.e., biobased nanoemulsion technology).View this paper.

Volume 6,Issue 1

Open Access Short Review

Arterial Elasticity: Linking of Cardiovascular Risks, Pulse Pressure, Dementia, Aging, and Drug Targeting

Received: 08 December 2021;  Published: 29 March 2022;  doi: 10.21926/obm.neurobiol.2201117


Cerebrovascular atherosclerosis, and several other cardiovascular (or "inflamm-aging" type) diseases, are more frequent and advanced in subjects with Alzheimer's disease compared with normal aging. In addition, the observed pathogenic link to dementia (and its associated cerebral microvascular damage) is readily explained by alterations of arterial elasticity. A therapeutic strategy to delay dementia could be based upon localized drug delivery, using lipid nanocarriers (i.e., biobased [...]

Open Access Review

Neuropathology and Therapeutics Addressing Glaucoma, a Prevalent Retina-Optic Nerve-Brain Disease that Causes Eyesight Impairment and Blindness

Received: 24 January 2022;  Published: 22 March 2022;  doi: 10.21926/obm.neurobiol.2201116


Glaucomatous optic neuropathy (GON) associated with different forms of glaucoma and chronic ocular hypertension (cOHT) is characterized by progressive loss of retinal ganglion cells and their axons in the optic nerves that project to the brain to transmit visual information. The resultant thinning of the optic nerves cause loss of peripheral vision, which if not halted or slowed, can lead to irreversible blindness. Whilst the precise triggering insult(s) for the primary open angle gl [...]

Open Access Review

Analysis of Migraine Pathophysiology by Magnetic Resonance Imaging

Received: 25 October 2021;  Published: 08 February 2022;  doi: 10.21926/obm.neurobiol.2201115


Magnetic resonance imaging (MRI) has been used to investigate migraine pathophysiology because it is a non-invasive technique. The main aim of clinical imaging for patients with headaches is to exclude secondary headaches due to organic lesions. Conventional structural imaging techniques such as routine MRI demonstrate white matter lesions, changes in gray matter volume or cortical thickness, and cerebral blood flow in patients with migraine. Changes in metabolite levels are observed by magnetic [...]

Open Access Editorial

Acknowledgement to Reviewers of OBM Neurobiology in 2021

Received: 05 January 2022;  Published: 06 January 2022;  doi: 10.21926/obm.neurobiol.2201114


The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitli [...]