by Alessandro Stasi  and Krittinon Choavaratana

Received: 14 May 2025;  Published: 15 July 2025;  doi: 10.21926/obm.genet.2503304

Ongoing global conflicts and humanitarian crises have led to unprecedented displacement, including millions of separated children, many of whom, especially infants, cannot be traced using traditional methods. This paper advocates for the establishment of a voluntary, privacy-protected global DNA database, managed by an extra-governmental entity, to facilitate family reunification. It presents a comprehensive socio-technical framework that synthesizes a novel operational model with the requisite [...]

by Dagmar Moravčíková  , Jana Žiarovská  and Alžbeta Žiarovská

Received: 17 January 2025;  Published: 15 July 2025;  doi: 10.21926/obm.genet.2503303

The study of endophytic and rhizosphere microbiota offers considerable potential for applications in agriculture, biotechnology, and bioremediation, given the phytoremediation capacity of Amaranthus cruentus var. Pribina performed a detailed analysis of the root and rhizosphere microbial communities under cadmium (Cd) stress. Although metagenomics provides powerful tools for microbial community profiling, the reproducibility and interpretability of the results are strongly i [...]

by Lyubov Starodub  , Nataliia Mokhnachova  and Ostap Zhukorskyi

Received: 16 April 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503302

Characterization of the non-coding part of the transcriptome is a supplement to the annotation of the genome of living organisms. According to ISSR-fingerprinting data, information is obtained about ancient gene pools, modern gene pools, genetic variability and conservation of breeds and species of farm animals. The aim of the study is to study the molecular genetic component and phylogenetic relationships in the aboriginal Hutsul horse breed and fossil [...]

by Shayan Balkhi  , Marie Saghaeian Jazi  , Nader Mansour Samaei  , Nahid Rezaie  and Mahtab Farahmandrad

Received: 14 March 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503301

Glioblastoma (GBM) is the most aggressive primary brain tumor, with poor prognosis despite advancements in understanding its biology. Melatonin, a key regulator of metabolism and cellular homeostasis, is known for its neuroprotective and anti-cancer properties. While traditionally linked to pineal gland secretion, emerging evidence suggests that glioblastoma cells can produce melatonin within their mitochondria. This study investigates whether serum shock can influence endogenous melatonin produ [...]

by Pierre-Yves Maillard  , Sima Tokajian  , Marie Vilaire-Meunier  , Charbel Al Khoury  , Cybel Mehawej  , Eliane Chouery  , Marie-Anne Caillaud  , Louise Maillebouis  , Ines Ben Smida  , Sophie Durand  , Aimé Ravel  , Cecile Cieuta-Walti  , Marie-Noëlle Ungeheuer  , Clotilde Mircher  and André Mégarbané

Received: 05 October 2024;  Published: 03 July 2025;  doi: 10.21926/obm.genet.2503300

To investigate the potential impact of the additional chromosome 21 on the gut microbiome in patients with Down syndrome (DS), two monozygotic (MZ) and two dizygotic (DZ) twin pairs discordant for DS were studied. Whole-genome shotgun sequencing was conducted to analyze the taxonomic and functional profiles of the gut microbial community in the twins and assess whether the gut microbiome composition influences the development of psychological pathologies. Sequencing generated a total of 2,338,13 [...]