Molecular and in Silico Analysis of MEFV Variants in Familial Mediterranean Fever Patients in Southwest Iran
by
Negar Noorbakhsh
,
Mina Zamani
,
Alireza Sedaghat
,
Jawaher Zeighami
,
Farangis Foroughi
,
Sahere Parvas
,
Alihossein Saberi
,
Mohammad Hamid
,
Roya Ghanavati
,
Gholamreza Shariati
and
Hamid Galehdari











Abstract
Familial Mediterranean Fever (FMF) is classified as an autoinflammatory genetic disease inherited by mutations in MEFV. These mutations can affect the dysregulation of inflammatory processes in the human body and lead to fever and pain in the chest and abdomen. Many known missense mutations in MEFV are linked to FMF disease. Mutations in MEFV in most cases are located on the short arm of chromosome 16 and can impair the function of t [...]