A Probiotic Mixture Decreases Neuropathy and Oxidative Stress Markers in Diabetic Rats
Abstract
31 263
A Probiotic Mixture Decreases Neuropathy and Oxidative Stress Markers in Diabetic Ratsby
Mohammad Shabani
,
Elham Hassanpour
,
Fatemeh Aghighi
,
Mojgan Mohammadifar
,
Fereshteh Bahmani
and
Sayyed Alireza Talaei
Abstract
Diabetic neuropathy (DN) is a type of nerve damage caused by long-term hyperglycemia in diabetes mellitus (DM). The gut microbiota alters in DM. Therefore, improvement of the gut flora may affect neuropathic pain and oxidative biomarkers' responsiveness to the probiotic treatment. The present study aimed to assess the effects of probiotic supplementation on neuropathic pain and oxidative stress biomarkers in diabetic rats’ serum. Forty-eight rats (200-250 g) were randomly divided into four groups (n = 12 per group) [...] 31 263 |
Breaking Barriers: A Reliable Method for RNA Extraction in Zebrafish Neurodegenerative ResearchAbstract
Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...] 30 229 |
Mental Hindrances and Entrepreneurial Supports towards Psychological Wellbeing among EntrepreneursAbstract
University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...] 41 355 |
Illuminate Resection Pathways with Fluorescence Guidance in Glioma Surgery: Case Reports and Systematic Reviewby
Manuel De Jesus Encarnacion Ramirez
,
Nikolay Konovalov
,
Stanislav Kaprovoy
,
Gennady Chmutin
,
Geovany Venegas Cerna
,
Renat Nurmukhametov
,
Andreina Rosario Rosario
,
Kalin Ivan Yakovlevich
,
Jesus Lafuente
,
Eric Suero Molina
and
Nicola Montemurro
Abstract
Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...] 79 633 |
The Origin of Social Skills: Manipulating Shared Intentionality in Bioengineering Systems for Empathy Trainingby
Igor Val Danilov
and
Sandra Mihailova
Abstract
This pilot study (N = 28) aims to develop universal computer-aided empathy training. The experiment tests a research design of manipulating behavior in subjects toward non-affective cues in a bioengineering system. The study implements the Mother-Fetus Neurocognitive Model to involve subjects in subliminal cognitive collaboration with confederates, which enables subjects to associate the meaning of empathy with the picture only seen by confederates. The outcome shows the feasibility of the chosen research design wi [...] 90 805 |
Enhancing Students’ Brain Development through Technology Use and Digital CharacteristicsAbstract
In the present era of digitalization, technology plays a prominent role in relaxation and brain development (BD), specifically for university students. The present study explores the impact of technology use and digital characteristics (DC) in developing students' BD. We applied the quantitative methods; the study collected 328 samples from Egypt's different public sector universities through a questionnaire. Using path analysis through analysis of moment structures (AMOS), the results demonstrate a positive effect [...] 92 794 |
Recognizing the Role of ChatGPT in Decision-Making and Recognition of Mental Health Disorders among EntrepreneursAbstract
Nowadays, mental health disorders have become a significant concern for everyone. There are diverse reasons emanating from the workplace, business, and everyday environment. Therefore, there is a current need to use technology to detect and review their symptoms and causes. Accordingly, in this study, the researcher attempted to recognize ChatGPT’s role in decision-making and the recognition of mental health disorders among Egyptian entrepreneurs. The researcher used a quantitative approach in this study based its [...] 84 950 |
Using Technologies to Promote Adaptive Responding and Reduce Challenging Behaviors in Children with Autism Spectrum Disorder: A Selective Reviewby
Anna Passaro
,
Antonio Zullo
,
Mariacarla Di Gioia
,
Mirella Dragone
,
Khalida Akbar
and
Fabrizio Stasolla
Abstract
The management and treatment of challenging behaviors in children diagnosed with Autism Spectrum Disorder (ASD) is a priority for caregivers, educators, and healthcare professionals. This selective review examined how different technologies were used to help manage challenging behaviors in children with autism, describing each technology's strengths, weaknesses, and applications. This paper aimed to provide accessible choices for caregivers, educators, and healthcare professionals, enabling them to make well-inform [...] 71 776 |
Oxidative Stress in Cerebral Ischemia/Reperfusion Injuryby
Roberto Anaya-Fernández
,
Roberto Anaya-Prado
,
Michelle M. Anaya-Fernandez
,
Miguel A. Guerrero-Palomera
,
Ivan F. Garcia-Ramirez
,
Daniel Gonzalez-Martinez
,
Consuelo C. Azcona-Ramirez
,
Citlalli S. Guerrero-Palomera
,
Claudia Garcia-Perez
,
Bernardo Tenorio-Gonzalez
,
Jose E. Tenorio-Gonzalez
,
Laisha F. Vargas-Ascencio
,
Abraham I. Canseco-Villegas
,
Gustavo Servin-Romero
,
Allen R. Barragan-Arias
and
Bruno Reyna-Rodriguez
Abstract
Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...] 97 1087 |
Tau-Targeted Immunotherapy for Alzheimer's Disease: Insight into Clinical TrialsAbstract
The use of immunotherapy as a therapeutic approach to Alzheimer's Disease (AD) is gaining rapid interest, with the primary goal of targeting abnormalities that impact neuronal viability through specific antibodies. Currently, clinical strategies focus intensively on targeting the two main pathologies associated with AD, beta-amyloid (Ab) and tau. This review examines ongoing research in the realm of tau immunotherapy, including clinical trials that demonstrate promising potential for halting AD progression. Several [...] 92 963 |
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