by Ferydoon Khamooshi  , Samaneh Doraji-Bonjar  , Ali Reza Modarresi-Alam  and Mohammad Hasan Mohammadi

Received: 03 May 2025;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601318

The study explores the crucial biological function of nitrogen in cyclic and acyclic structures with resonance potential, including tetrazoles, pyrroles, piperidines, and carbamates, within the realm of chemical neuroscience. It highlights the importance of these compounds for their biological properties and their ability to cross the blood-brain barrier (BBB) to reach the central nervous system (CNS). The study emphasizes the necessity for neurochemical drugs, like morphine, to effectively cross the BBB, as modifi [...]

by OBM Neurobiology Editorial Office

Received: 04 January 2026;  Published: 04 January 2026;  doi: 10.21926/obm.neurobiol.2601317

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2025. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web of [...]

by Zekeriya Temircan

Received: 09 March 2025;  Published: 31 December 2025;  doi: 10.21926/obm.neurobiol.2504316

This study aimed to examine the psychological flexibility of individuals diagnosed with borderline personality disorder (BPD) compared to healthy controls. Psychological flexibility is a key construct related to mental health and adaptive functioning, and understanding its levels in BPD can provide insight into symptom severity and treatment outcomes. The study included 58 individuals diagnosed with BPD and 62 healthy volunteer controls, all meeting specific inclusion and exclusion criteria. Participants completed [...]

by Giustino Varrassi  , Matteo Luigi Giuseppe Leoni  , Giacomo Farì  , Annalisa Caruso  , Ameen Abdulhasan Al-Alwany  , Marco Mercieri  , Joseph V. Pergolizzi  and Rocìo Guillen

Received: 10 September 2025;  Published: 12 December 2025;  doi: 10.21926/obm.neurobiol.2504315

Chronic cancer pain results from the complex interaction of nociceptive, neuropathic, and neuroimmune mechanisms, which vary according to tumor type, location, stage, and treatment history. Recent advances in cancer neuroscience have reframed pain as a dynamic manifestation of reciprocal tumor–nerve–immune interactions, rather than a mere consequence of tissue damage. In this model, malignant, stromal, and immune cells remodel nociceptive circuits at peripheral and central levels. This narrative review, conducted i [...]

by Rustam Nailevich Mustafin

Received: 17 August 2025;  Published: 08 December 2025;  doi: 10.21926/obm.neurobiol.2504314

Schizophrenia is a multifactorial mental disorder associated with multiple SNPs in the human genome, located mainly outside the annotated protein-coding genes. These regions contain a large number of retroelements, which drive epigenetic regulation. Therefore, it is suggested that schizophrenia-associated SNPs exert their influence on the pathological functioning and activation of retroelements, which contribute to epigenetic imbalance in the brain with the development of pathological processes. A reflection of the [...]

by Giulio E. Lancioni  , Gloria Alberti  , Chiara Filippini  , Nirbhay N. Singh  , Mark F. O’Reilly  and Jeff Sigafoos

Received: 18 August 2025;  Published: 27 November 2025;  doi: 10.21926/obm.neurobiol.2504313

Recent work with people with blindness and intellectual disability assessed a technology-aided program intended to help eight participants travel indoor routes to reach relevant destinations. The technology included a smartphone, two barcode readers worn by the participants at their ankles, barcodes displayed at specific points of the travel routes, and a mini speaker. The technology ensured that participants received verbal instructions on how to proceed (e.g., take a left turn, cross from one side to the other of [...]

by Ami Rokach

Received: 24 August 2025;  Published: 25 November 2025;  doi: 10.21926/obm.neurobiol.2504312

A significant social stigma is associated with loneliness. The prevalence of social isolation, in the dawn of the 21st century points to the growing isolation in America. Lonely people who commonly display negative self-perceptions, show great difficulty to establish social ties, and that may be related to their personal inadequacies, or socially undesirable attributes. Lonely people suffer from a low social perception, painting them as less psychologically adjusted, and not very capable in relating to others. That [...]

by Mohammad Azimi Tabas  , Maryam Kazerani  , Azam Shahbodaghi  and Reza Taherian

Received: 24 June 2025;  Published: 19 November 2025;  doi: 10.21926/obm.neurobiol.2504311

The widespread use of social media among college students has become a significant concern due to its potential impact on mental health and addictive behaviors. Social media platforms, while offering numerous benefits, can also foster environments that contribute to addiction, depression, and anxiety. College students, in particular, are vulnerable to these effects due to their high levels of social media engagement and the pressures of academic life. Mental health literacy, which involves understanding and managin [...]

by Marina M Gerges  and Vladimir Kosonogov

Received: 02 May 2025;  Published: 19 November 2025;  doi: 10.21926/obm.neurobiol.2504310

Emotion regulation (ER) involves processes by which individuals modulate the intensity, duration, and expression of emotional responses, and its dysregulation is associated with a broad spectrum of psychological disorders. While traditionally conceptualized within psychological frameworks, ER is increasingly recognized as biologically grounded, involving intricate interactions between neurochemical, hormonal, and metabolic systems. This narrative review aims to synthesize current evidence on biochemical substrates [...]

by Icih Susanti  , Noki Irawan Saputra  , Lina Budiyanti  , Aam Amalia  , Rohman Hikmat  and Iyus Yosep

Received: 11 September 2025;  Published: 17 November 2025;  doi: 10.21926/obm.neurobiol.2504309

Adolescent depression is linked to suicidal ideation and attempts. Nurses are well-positioned to deliver brief, supportive interventions. Solution-Focused Brief Therapy (SFBT) emphasizes solutions and the activation of personal resources. To describe the feasibility and clinical utility of SFBT, delivered alongside pharmacotherapy, for reducing suicide risk in an adolescent with depression. Single-case report using a nursing process approach in a 17-year-old female inpatient with a major depressive episode and high [...]