Table of Content

Open Access Original Research

A Probiotic Mixture Decreases Neuropathy and Oxidative Stress Markers in Diabetic Rats

Received: 11 May 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403247

Abstract

Diabetic neuropathy (DN) is a type of nerve damage caused by long-term hyperglycemia in diabetes mellitus (DM). The gut microbiota alters in DM. Therefore, improvement of the gut flora may affect neuropathic pain and oxidative biomarkers' responsiveness to the probiotic treatment. The present study aimed to assess the effects of probiotic supplementation on neuropathic pain and oxidative stress biomarkers in diabetic rats’ serum. Forty-eight rats (200-250 g) were randomly divided into four groups (n = 12 per group) [...]

31 263

Open Access Original Research

Breaking Barriers: A Reliable Method for RNA Extraction in Zebrafish Neurodegenerative Research

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Abstract

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

30 229

Open Access Original Research

Mental Hindrances and Entrepreneurial Supports towards Psychological Wellbeing among Entrepreneurs

Received: 21 May 2024;  Published: 18 September 2024;  doi: 10.21926/obm.neurobiol.2403245

Abstract

University entrepreneurs' psychological wellbeing (PWB) is a gigantic problem that substantially affects their academic performance, health, innovative capabilities, and more comprehensive societal contributions. In this study, we examine mental hindrances, such as stress, anxiety and depression and entrepreneurship-related constructs, such as entrepreneurial purpose (ENSE), entrepreneurial carefulness (ENSS) and entrepreneurial desire (ENRE) that predict PWB among Egyptian university entrepreneurs. In this quantit [...]

41 355

Open Access Review

Illuminate Resection Pathways with Fluorescence Guidance in Glioma Surgery: Case Reports and Systematic Review

Received: 20 April 2024;  Published: 09 September 2024;  doi: 10.21926/obm.neurobiol.2403244

Abstract

Gliomas are the most common brain tumor in adults, with a poor prognosis despite intensive treatments. Complete surgical resection is difficult due to its infiltrative growth, but aggressive surgery improves outcomes. Fluorescence-guided surgery (FGS) is used to distinguish tumor tissue during surgery. 5-Aminolevulinic Acid (5-ALA) is a crucial fluorescent agent in FGS, transforming into a molecule that accumulates in tumor cells. We presented a 34-year-old female with a high-grade glioma in the left parietal lobe [...]

79 633

Open Access Original Research

The Origin of Social Skills: Manipulating Shared Intentionality in Bioengineering Systems for Empathy Training

Received: 12 March 2024;  Published: 28 August 2024;  doi: 10.21926/obm.neurobiol.2403243

Abstract

This pilot study (N = 28) aims to develop universal computer-aided empathy training. The experiment tests a research design of manipulating behavior in subjects toward non-affective cues in a bioengineering system. The study implements the Mother-Fetus Neurocognitive Model to involve subjects in subliminal cognitive collaboration with confederates, which enables subjects to associate the meaning of empathy with the picture only seen by confederates. The outcome shows the feasibility of the chosen research design wi [...]

90 805

Open Access Original Research

Enhancing Students’ Brain Development through Technology Use and Digital Characteristics

Received: 12 May 2024;  Published: 19 August 2024;  doi: 10.21926/obm.neurobiol.2403242

Abstract

In the present era of digitalization, technology plays a prominent role in relaxation and brain development (BD), specifically for university students. The present study explores the impact of technology use and digital characteristics (DC) in developing students' BD. We applied the quantitative methods; the study collected 328 samples from Egypt's different public sector universities through a questionnaire. Using path analysis through analysis of moment structures (AMOS), the results demonstrate a positive effect [...]

92 794

Open Access Original Research

Recognizing the Role of ChatGPT in Decision-Making and Recognition of Mental Health Disorders among Entrepreneurs

Received: 01 April 2024;  Published: 19 August 2024;  doi: 10.21926/obm.neurobiol.2403241

Abstract

Nowadays, mental health disorders have become a significant concern for everyone. There are diverse reasons emanating from the workplace, business, and everyday environment. Therefore, there is a current need to use technology to detect and review their symptoms and causes. Accordingly, in this study, the researcher attempted to recognize ChatGPT’s role in decision-making and the recognition of mental health disorders among Egyptian entrepreneurs. The researcher used a quantitative approach in this study based its [...]

84 950

Open Access Review

Using Technologies to Promote Adaptive Responding and Reduce Challenging Behaviors in Children with Autism Spectrum Disorder: A Selective Review

Received: 30 May 2024;  Published: 15 August 2024;  doi: 10.21926/obm.neurobiol.2403240

Abstract

The management and treatment of challenging behaviors in children diagnosed with Autism Spectrum Disorder (ASD) is a priority for caregivers, educators, and healthcare professionals. This selective review examined how different technologies were used to help manage challenging behaviors in children with autism, describing each technology's strengths, weaknesses, and applications. This paper aimed to provide accessible choices for caregivers, educators, and healthcare professionals, enabling them to make well-inform [...]

71 776

Open Access Review

Oxidative Stress in Cerebral Ischemia/Reperfusion Injury

Received: 02 May 2024;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403239

Abstract

Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...]

97 1087

Open Access Review

Tau-Targeted Immunotherapy for Alzheimer's Disease: Insight into Clinical Trials

Received: 16 August 2023;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403238

Abstract

The use of immunotherapy as a therapeutic approach to Alzheimer's Disease (AD) is gaining rapid interest, with the primary goal of targeting abnormalities that impact neuronal viability through specific antibodies. Currently, clinical strategies focus intensively on targeting the two main pathologies associated with AD, beta-amyloid (Ab) and tau. This review examines ongoing research in the realm of tau immunotherapy, including clinical trials that demonstrate promising potential for halting AD progression. Several [...]

92 963

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