by Prasanna N. de Silva

Received: 10 September 2020;  Published: 26 November 2020;  doi: 10.21926/obm.neurobiol.2004078

This study looked at secondary care utilization metrics as an effectiveness indicator of Clozapine initiation in 77 patients over the following year compared to the year prior to initiation. It was found that there was a marginal drop in psychiatric bed utilization, alongside reduced crisis team use. Medical and psychiatric outpatient use increased, as did physical health interventions. Overall, compared with costs over the year preceding Clozapine initiation, an estimated saving per patient of £3,867 (5,065) was a [...]

by Isabelle Jourdain  , Michael Knorr  , Lukas Brieger  and Carsten Strohmann

Received: 07 September 2020;  Published: 25 November 2020;  doi: 10.21926/acr.2004009

The dinuclear complexes [Co2(CO)6{P(OAr)3}2] (1a, Ar = Ph; 1b, Ar = o-Tol) were prepared and reacted with PhC≡CH and PhC≡CPh to yield dimetallatetrahedranes [{(ArO)3P}(OC)2Co-Co(μ-RC≡CPh)(CO)2{P(OAr)3}] (3a, Ar = Ph, R = H; 3b, Ar = o-Tol, R = H; 3c, Ar = Ph, R = Ph; 3d, Ar = o-Tol, R = Ph). The main reaction of diphenylacetylene was accompanied by a side reaction, leading to the dissociation of a P(OAr)3 ligand for the formation of mono(phosphite) complexes [{(ArO)3P}(OC)2Co-Co(μ-PhC≡CPh)(CO)3] (2b, R = Ph; 2d, R [...]

by Keith D Hutchison  and Barbara Iisager

Received: 13 September 2020;  Published: 24 November 2020;  doi: 10.21926/aeer.2004004

The processes relevant to the verification of cloud forecasts generated by climate models are discussed from an engineering perspective. These processes include an assessment of cloud product requirements to be evaluated, the creation of a verification test plan including procedures and data to be analyzed, the development of independent sources of validation or truth datasets, and the quantitative comparisons between the cloud forecast products and the truth data needed to establish model performance. The engineer [...]

by Samuel Cruz-Manzo

Received: 31 July 2020;  Published: 24 November 2020;  doi: 10.21926/jept.2004017

In this study, uncertainties during the assessment of the electrochemical impedance spectrum of the polymer electrolyte fuel cell (PEFC) attributed to inductive artefacts at high frequencies and inductive loops at low frequencies as well as oxygen diffusion time constant are discussed. A validated impedance model represented as an equivalent electrical circuit of a PEFC allowed the simulation of the effect of inductive artefacts, inductive loops and oxygen diffusion time constant on electrochemical impedance spectr [...]

by Katarzyna Grubel  , Ji Su  , Jotheeswari Kothandaraman  , Kriston Brooks  , Gabor A. Somorjai  and Tom Autrey

Received: 01 September 2020;  Published: 23 November 2020;  doi: 10.21926/jept.2004016

In this perspective on hydrogen carriers, we focus on the needs for the development of robust active catalysts for the release of H2 from aqueous formate solutions, which are non-flammable, non-toxic, thermally stable, and readily available at large scales at reasonable cost. Formate salts can be stockpiled in the solid state or dissolved in water for long term storage and transport using existing infrastructure. Furthermore, formate salts are readily regenerated at moderate pressures using the same catalyst as for [...]

by Xuepeng Zhao

Received: 21 August 2020;  Published: 23 November 2020;  doi: 10.21926/aeer.2004003

Nearly 40 years of aerosol optical thickness (AOT) climate data record (CDR) from AVHRR satellite observations over the global ocean is used to study the impact of COVID-19 lockdowns and Australian bushfires on aerosol loading over downwind oceanic regions. Recent similar impact studies, by contrast, were mainly focused on the urban and suburban areas near the emission sources. AOT is used as a proxy for aerosol loading in our study. We found that AOT variations due to anthropogenic emission reduction during the lo [...]

by Kamal Kant Sahu

Received: 01 November 2020;  Published: 19 November 2020;  doi: 10.21926/obm.transplant.2004126

by Meir Djaldetti  , Chiya Moshe Leibovitch  and Hanna Bessler

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased produc [...]

by Chiara Castellani  , Emanuele Molteni  , Serena Colafrancesco  , Fabrizio Conti  , Roberta Priori  and Rossana Scrivo

Received: 13 August 2020;  Published: 18 November 2020;  doi: 10.21926/obm.geriatr.2004139

Musculoskeletal conditions represent one-third to more than one-half of all non-communicable disease multimorbidities in the elderly, worsening their disability because of pain and limited physical function, often concurring with their mental decline. Musculoskeletal conditions significantly contribute to frailty and global disability, second only to mental health conditions. Furthermore, premature mortality, generally due to an increased risk of developing cardiovascular disease, has been documented in several rhe [...]

by Preeti Chhabra  and Kenneth L. Brayman

Received: 20 September 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004125

Clinical islet allotransplantation represents a minimally invasive, efficacious alternative to pancreas transplantation for restoring glycemic control and insulin independence in select patients with type 1 diabetes that is complicated by intractable impaired hypoglycemia awareness and/or severe hypoglycemic events refractory to stabilization by other means. Over the last decade, islet transplantation outcomes have steadily improved in part due to refinements in the selection of optimal donors, islet isolation tech [...]