by Beom-Jin Lee  , Manal Hadi Ghaffoori Kanaan  , Sura Saad Abdullah  and Abdolmajid Ghasemian

Received: 04 July 2025;  Published: 18 August 2025;  doi: 10.21926/obm.genet.2503308

Cancer continues to be one of the leading causes of global death, and conventional therapies have limited efficacy because of their toxicity, drug resistance, and off-target effects. Plant-derived nanoparticles (PDNPs) have emerged as suitable alternatives as they have biocompatibility, biodegradability, and multifunctional therapy. In this review, we discussed the recent advancements in PDNPs for cancer therapy, including the green synthesis of PDNPs using phytochemical (flavonoids, terpenoids) reducing and cappin [...]

by Khevin Jade Gumaru  , Harley Rodriguez  and Ourlad Alzeus G. Tantengco

Received: 12 January 2025;  Published: 15 August 2025;  doi: 10.21926/obm.genet.2503307

Breast cancer is a significant health problem. Epigenetic alterations that influence gene expression were implicated in breast cancer pathogenesis. Bibliometric analysis can be done to evaluate the existing literature and identify gaps and emerging trends. This bibliometric analysis aims to provide an overview of the current landscape of global breast cancer epigenetics research, identify existing networks of countries and authors’ keywords, and assess the association of a country’s socioeconomic indica [...]

by Abdulmalik Ahmad Lawan  , Hauwa Zakariyya Abdullahi  , Abdullahi Yunusa Abdullahi  and Sadiya Tahir

Received: 16 January 2025;  Published: 15 August 2025;  doi: 10.21926/obm.neurobiol.2503298

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with significant heterogeneity in symptoms and comorbid conditions. Studies have shown the value of early and accurate diagnosis in mitigating the associated social and behavioral challenges. Recently, studies have demonstrated the potential of machine learning (ML) models in identifying ASD patterns from neuroimaging, genetic, and behavioral data. However, the limited interpretability of these models poses a barrier to their clinical adopti [...]

by Ami Rokach

Received: 08 May 2025;  Published: 14 August 2025;  doi: 10.21926/obm.neurobiol.2503297

Loneliness, social isolation, aloneness, and solitude may be used interchangeably by some who may miss the difference between them. Loneliness is the experience of being alone, or perceiving that one is alone and unimportant to others. Solitude is being geographically isolated out of one’s choice. Loneliness is not a feeling, but a multidimensional construct which is expressed cognitively, behaviorally and affectively. solitude is also reviewed and a clear distinction between loneliness and solitude is established. [...]

by Zhichao Wang  , Daisuke Mori  , Sou Taminato  , Yasuo Takeda  , Osamu Yamamoto  and Nobuyuki Imanishi

Received: 28 April 2025;  Published: 13 August 2025;  doi: 10.21926/jept.2503011

Solid lithium-ion conducting polymer electrolytes are attractive candidates for battery applications because they are flexible and less flammable, and can be easily prepared as large-sized thin films. However, the room temperature conductivity of conventional polymer electrolytes is relatively low, and detrimental lithium dendrite formation is observed at high current density. In this study, a composite polymer electrolyte of polyethylene oxide (PEO) with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and a hi [...]

by Ali Barikroo  and Alyssa Zinser

Received: 28 April 2025;  Published: 13 August 2025;  doi: 10.21926/obm.geriatr.2503322

Age-related decline in swallowing function increases the risk of dysphagia in older adults. Strengthening the muscles involved in swallowing through proactive training may help prevent such decline, particularly in prefrail individuals. This case series evaluated the feasibility and physiological effects of a home-based effortful swallow training program in three prefrail older adults without swallowing impairments. The intervention used a wearable surface electromyography biofeedback device (Mobili-T®) to provide [...]

by Masoume M. Raeissi  and Rob Knapen

Received: 07 April 2025;  Published: 12 August 2025;  doi: 10.21926/aeer.2503028

Environmental science addresses critical global challenges, including climate change, biodiversity loss, and sustainability. These complex topics generate a vast amount of both structured and unstructured data, from remote sensing output to policy documents, guidelines, and scientific literature. Effectively processing and utilizing this information is essential for advancing research and supporting decision-making. Large Language Models (LLMs) have shown remarkable capabilities in natural language understanding an [...]

by Mohan Tanniru  and Amanda Sokan

Received: 03 March 2025;  Published: 11 August 2025;  doi: 10.21926/obm.geriatr.2503321

Aging is a multifaceted journey shaped by diverse life-course experiences, which contribute both to the challenges populations face in achieving their health goals and to the competencies they can bring to sustain health and aging. Community strategies designed to support population health—by leveraging technology and external partners—require transformation to effectively extend their focus to aging-related goals. In this paper, we adopt a service lens to examine how these community strategies, which co-produce pr [...]

by Edward F. Coyle

Received: 20 February 2025;  Published: 08 August 2025;  doi: 10.21926/obm.geriatr.2503320

The shrinkage of muscles with age, beginning at 30 y and accelerating in old age, is due largely to atrophy of fast-twitch muscle fibers (FT) partly from disuse. It was our purpose to develop an exercise program that is effective and time efficient at stimulating FT, as well as slow-twitch fibers (ST), to offset their atrophy. FT are recruited during movements requiring very high force and/or high velocity. We developed a safe exercise cycle that allows a person to ‘accelerate’ with the maximal effort needed to rec [...]

by Ryan S. Wexler  , Natasha Parman  , Devon J. Fox  , Danielle ZuZero  , Anand Parikshak  , Sophia Kwin  , Austin R. Thompson  , Hans L. Carlson  , Thomas Kern  , Scott D. Mist  , Ryan Bradley  , Heather Zwickey  and Courtney K. Pickworth

Received: 06 January 2025;  Published: 07 August 2025;  doi: 10.21926/obm.icm.2503035

Lumbosacral radicular pain (LRP) is a common sequelae of low back pain, the world’s leading cause of years lived with disability. LRP typically causes numbness, weakness, and tingling into the lower extremity and is associated with high rates of pain and impaired function. Despite its prevalence, there is significant heterogeneity among clinical practice guidelines for the treatment of LRP, which may contribute to poor patient outcomes. The aim of the present study was to identify treatments that participants [...]