by Niamh Flynn

Received: 18 March 2021;  Published: 02 May 2021;  doi: 10.21926/obm.neurobiol.2102092

Although studies to understand the pathogenesis of migraines are in progress, no theory has adequately explained the etiology and pathophysiology of migraines to date. This has affected the development of treatment strategies for migraineurs. Currently, the pharmacological treatment for migraines provides both acute and prophylactic options to patients based on a biomedical model of pain. However, patients’ adherence to oral migraine preventive medication (OMPM) is poor, and their persistence is even lower when the [...]

by Ethan Fitzgerald  , Dorian Mateusz Kusyk  and Nestor D Tomycz

Received: 02 December 2020;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102170

Alzheimer’s Disease (AD) is the leading cause of dementia worldwide, and represents a significant cause of cognitive decline, disability, and mortality. Ongoing clinical trials continue to investigate β-amyloid targeted therapy with unclear benefit, and we are currently limited to symptomatic treatment. Therefore, there is a salient need for the development of novel, potentially disease-modifying therapeutic strategies such as deep brain stimulation. This manuscript reviews Deep Brain Stimulation in Alzheimer’s Dis [...]

by Scott A. Trudeau  and Megan E. Gately

Received: 08 February 2021;  Published: 30 April 2021;  doi: 10.21926/obm.geriatr.2102169

The Reading Buddies Program was developed as a service-learning component of an Occupational Therapy Practice with Older Adults course as a collaboration between Tufts University and the VA Bedford Health Care System. The purpose of this service-learning program was to challenge graduate students’ implicit biases and improve communication skills when working with older adults with significant cognitive impairments. Through this collaboration, occupational therapy students provided individualized, activity-based car [...]

by Gunasekaran Singaravelu  , Calvin B Harley  , Joseph M Raffaele  , Pratheesh Sudhakaran Sudhakaran  and Anitha Suram

Received: 27 January 2021;  Published: 29 April 2021;  doi: 10.21926/obm.geriatr.2102168

TA-65 is a small molecule telomerase activator extracted from Astragalus species. A previous observational study suggested that TA-65 decreased the number of immunosenescent cells in healthy subjects. Here we examined the impact of TA-65 in a much larger randomized, double-blind, and placebo-controlled study. This study aims to evaluate the effects of TA-65 on senescent CD8+CD28- T cells in healthy subjects. This was a randomized, double-blind, placebo-controlled, and multi-arm parallel trial in 500 healthy subject [...]

by Yi-Chun Hsu  , Min-Ze Lu  and Chang-Ming Liaw

Received: 18 December 2020;  Published: 28 April 2021;  doi: 10.21926/jept.2102018

This paper proposes a Wind Turbine Emulator (WTE) using an Indirect Field Oriented (IFO) Induction Motor (IM). The IM drive can be controlled as a conventional prime mover in speed mode, or a wind turbine in torque-speed mode via robust observed torque control. This paper presents key issues for establishing a high-performance IFO IM drive. Further, this study develops a wind turbine load Interior Permanent-Magnet Synchronous Generator (IPMSG) followed by a three-phase Vienna Switch-Mode Rectifier (SMR). It receive [...]

by Carlos A. Echeverry-Gonzalez  and Vladimir V. Kouznetsov

Received: 01 December 2020;  Published: 28 April 2021;  doi: 10.21926/rpm.2102015

The design of nanomaterials for application in diverse fields ranging from photovoltaic to fluorescence sensing is a research area of increasing interest. Recently, Quantum Dots (QDs), which are classified as semiconductor quantum dots (SQDs) and Carbon dots (CDs), have become a hot topic of investigation, owing to their extraordinary tunable fluorescence emission properties that render them excellent candidates for sensing metal ions. The detection of metal ions in aqueous solutions with high sensitivity is very i [...]

by CT Valliappan  , J Joyson Joe Asir  , V Subashri  , V Vaishnavi  and I Anand Sherwood

Received: 28 December 2020;  Published: 27 April 2021;  doi: 10.21926/rpm.2102014

Furcal perforation management in root canal retreatment is often challenging as the outcome of the perforation sealing depends on several parameters. The recent introduction of several bioactive cements and magnification systems has made the sealing of perforations easier and the outcome more predictable. This study highlights the clinical outcomes of furcal perforation management in root canal retreatment using biodentine.

by Haywantee Ramkissoon

Received: 23 February 2021;  Published: 27 April 2021;  doi: 10.21926/obm.icm.2102016

The SARS-COV-2 virus has changed people’s lives and caused significant public health issues. The lockdown implemented by several governments across the globe has raised serious concerns on mental and physical wellbeing. Doctors, nurses and other COVID-19 frontline workers being put under extreme pressure to attend to patients’ health are being impacted by high stress levels which can result in burn-out and the inability to cope with the situation. This paper draws on multi-disciplinary research including complement [...]

by Jordin Lane  and Kevin R. Fontaine

Received: 28 December 2020;  Published: 21 April 2021;  doi: 10.21926/obm.icm.2102015

Carbohydrate-restricted ketogenic diets (KD) were introduced in the mid-19th century as a weight loss method with a resurgence of its use in epilepsy treatment in the 1920’s. Research conducted over the last several years provides evidence that KD’s can confer beneficial effects for several chronic metabolic diseases, including obesity, type-2 diabetes, and polycystic ovary syndrome. In recent years, emerging evidence suggests KD’s may also have therapeutic benefits for some cancers and for neurological conditions [...]

by Sofía Albolafio  , María I. Gil  , Ana Allende  and Epameinondas Xanthakis

Received: 02 December 2020;  Published: 21 April 2021;  doi: 10.21926/rpm.2102013

The present study aimed to characterize wastewater fractions obtained after the wet extraction of proteins from legumes. In addition, the suitability of wastewater fractions for the potential recovery of high value-added compounds was also examined, and consequently, the prevention of the environmental impact of these wastes was explored. Similar to the industrial production of proteins, wet alkaline and acidic extractions of proteins from faba bean and pea flours were performed in two stages of extraction. The dif [...]