Cell Senescence, Telomerase, and Senolytic Therapy
Abstract
2257 35688
Cell Senescence, Telomerase, and Senolytic TherapyAbstract
The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable attention, but both theoretical considerations and published data suggest that the clinical benefits will be transient and that senolytic therapies will likely accelerate long-term degenerative disease. We review the ove [...] 2257 35688 |
Effect of Six-Months Supplementation with Cholecalciferol on Glycemic and Blood Pressure Control in Elderly Type 2 Diabetic Patients with Vitamin D Deficiency: A Pilot StudyAbstract
Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. Our aim was to evaluate in elderly uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-months vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels. Methods: In an open-label pilot study, thirty type 2 diabetic patients (age 71.5 ± 3.2 years, BMI [...] 1799 10551 |
Key Dimensions of Therapeutic Lies in Dementia Care: A New TaxonomyAbstract
Background: Research suggests that the use of lies and deception is prevalent within dementia care settings, despite ongoing debates raised about the ethics of this approach. There has been increasing exploration of when and why deceptive practices should be used, but the lack of clarity as to what constitutes a lie has caused difficulty in ensuring that lies are used ethically. The aim of this study was to widen our understanding of the key dimensions that underpin the use of lies, and further to use this informat [...] 2030 16276 |
Telomere Editorial - Perspectives on Telomeres and AgingAbstract
Telomere Editorial-Perspectives on Telomeres and Aging 1855 11869 |
An Examination of How the ‘Household Model' of Care Can Contribute to Positive Ageing for Residents in the ‘Fourth Age’Abstract
Background: Promoting a good quality of life for the oldest members of society has become a top priority as evidenced in UK policy. The ‘household’ model is a departure from traditional approaches to care provision since it offers person-centred support - combing health and social care - to older people in specially-designed, small, homelike environments. Having gained increasing popularity in care homes across developed countries, the impact of this model of service delivery on residents’ quality of life and its c [...] 2179 14530 |
Aging and the Art of Happiness: Time Effects of A Positive Psychology Program with Older Adultsby
Abstract
Background: Research has shown that positive psychology interventions can enhance subjective well-being and reduce depression. However, the efficacy of these programs with older adult populations has been minimally studied. The present study studied the short and long term impact of an intervention enhancing happiness and overall mental well-being in older adults. Methods: The Art of Happiness is an 8-week program conducted at 2 senior centers in the state of Delaware. Each 90-minute class examined a different topi [...] 2029 15935 |
Acceptance of Information and Communication Technologies for Healthy and Active Aging: Results from Three Field StudiesAbstract
Background: Information and Communication Technologies (ICTs) have the potential to promote healthy aging and increase the quality of life of older adults. However, several barriers like access, performance, psychological, and privacy issues still exist against fully deploying ICT solutions for older adults. To determine useful methods to overcome such barriers, this work investigated the possible factors that prevent elders from directly accepting ICT services based on three field studies. Methods: The Unified The [...] 1698 10010 |
What Activities Count as Active Aging? The Challenge of Classifying DiversityAbstract
Active aging is a concept used to describe and promote lifestyles that contribute to a healthy aging process. However, these lifestyles vary widely, and the concept of active aging encompasses many activities. This paper considers two axes to classify the range of activities that can contribute to active aging: the resources needed to carry out such activities (low and high-resource needs) and the main orientation of the activities (self-oriented vs. activity with others). To illustrate this classification, three t [...] 1916 11978 |
Understanding the Functional Roles of Multi-Modal Processing and Gc Activation In Older People's Performance in Caregiving Trainingby
Abstract
The current article addresses the working memory constraints experienced by older people in caregiving training. Two different approaches aiming to free the older people’s working memory space were discussed. They include multi-modal visual processing and Gc activation. The emphasis was on the theoretical underpinnings of both approaches with empirical evidence from the research and literature to demonstrate their effectiveness in older people’s caregiving training. Further discussion was made with respect to the t [...] 1681 11059 |
Wisdom and Curiosity Among Older Learners: Elucidating Themes of Well-Being from Beautiful Questions in Older Adulthoodby
Abstract
Background: Wisdom and curiosity require greater attention in the lifelong learning literature pertaining to older adulthood. Lifelong learning can assist older adults in amalgamating wisdom and pursuing their curiosities, but how wisdom is amalgamated and how curiosity is pursued in older adulthood needs more exploration. Methods: This qualitative study investigates subthemes of wisdom amalgamation and curiosity pursuits elucidated from interviews of older adults who participated in a university-based lifelong lea [...] 2128 19267 |
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