Journal Flyer

Current Issue 2018  Archive 2017 

Editor-in-Chief of OBM Hepatology and Gastroenterology

Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.

Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.


The Associate Editor of OBM Hepatology and Gastroenterology

Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.

Special Issue

Epigenetic Mechanisms in Health and Disease

Submission Deadline: May 31, 2018 (Open)               Submit Now

Guest Editors

Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
E-Mail: [email protected]
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells

Marcel Mannens, PhD
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
E-Mails: [email protected]; [email protected]
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics

Planned Papers

Title: Epigenetic changes if in vitro fertilization and embryo culture in humans
Authors: Arne Sunde
Affiliations: Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Title: Epigenetic regulation by androgen receptor in prostate cancer
Author: Ken-ichi Takayama1, 2
1. Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; E-mail: [email protected]
2. Department of Geriatric Medicine, the University of Tokyo, Tokyo, Japan
Prostate cancer is the most commonly diagnosed cancer in men all over the world. Androgen receptor (AR) functions as a nuclear receptor to facilitate ligand-dependent transcriptional activation in the nucleus. Advanced prostate cancer is treated with androgen deprivation therapy (ADT) because androgen and AR signaling drive the prostate tumor growth and anti-apoptotic ability. Resistance to ADT in most tumors develops quickly, but AR continues to be active in relapsed tumors called castration-resistant prostate cancer (CRPC). Therefore, it is important to understand AR transcriptional mechanism and downstream signaling. Recent studies have shown the central role of chromatin structure and histone modifications in determining AR-regulated genes. In addition, AR functions through interaction with several tissue-specific transcription factors such as forkhead box protein A1 (FOXA1). Interestingly, non-coding RNAs such as long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs) modulate epigenetic status to promote AR function directly or indirectly and have central roles in prostate cancer progressions. The focus of this review is on the involvement of AR in epigenetic regulation in prostate cancer development and progression

Title: Epigenetics and Human Reproduction
Author: Liborio Stuppia, MD1,2
Affiliation: 1. Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
2. Center for Aging Studies and Translational Medicine (CESI-MET), G. d’Annunzio University of Chieti-Pescara, Chieti, Italy, E-Mail: [email protected]
In the frame of the large interest recently devoted to the role played by epigenetic regulation of gene expression in human health and disease, a key point is represented by the involvement of epigenetic modifications in human reproduction, in terms of reduced fertility, abnormalities of embryo development and risk of early and late onset diseases in the offspring. In fact, epigenetic mechanisms play a key role in the control of male and female gametogenesis, and alterations in the correct organization of DNA methylation, chromatin modelling and miRNA production can affect not only the fertility of the couple, but also, by intergenerational or transgenerational effects, the health of the offspring at birth or during lifetime. A further element of variability in human reproduction is represented by the increasing use of Assisted Reproduction Techniques (ART), in turn able to induce epigenetic modifications in the embryo and increase the risk of related disorders.
In this review, we analyse the different features of the correlation between epigenetics modification and human reproduction, describing not only the risks related to alterations of the epigenetic organization in male and female gamete, but also suggesting that the reversibility of the epigenetic processes could represent a novel resource for the treatment of the infertility of the couple.

Title: Update on Epigenetics Landscape in Parkinson Disease and Lewy Body Dementia
Author: Simon Chiu
Affiliation: Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada

Title: non-coding RNAs in Melanoma development, progression and dissemination
Author: Delphine Fradin
Affiliation: Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France

Title: Similarities and differences of epigenetic mechanisms in chronic lymphocytic leukemia, myelodysplasia and acute myelod leukemia
Author: Cristina Bagacean1, 2, 3, Yves Renaudineau1, 2, 3
Affiliation: 1. U1227 B Llymphocytes & Autoimmunity, University of Brest, INSERM, IBSAM, Brest, France
2. Labex IGO, Networks IC-CGO & REpiCGO from ‘Canceropole Grand Ouest’, Brest, France
3. Laboratory of Immunology & Immunotherapy, Brest University Medical School Hospital, Brest, France

Title: Uniparental disomy and imprinting disorders
Authors: Thomas Eggermann, Z. Tümer, Glostrup, DK
Affiliations: Institut für Humangenetik, der RWTH Aachen, Pauwelsstr. 30 52074 Aachen, Germany



The role of epigenetics in developmental programming and the developmental origins of health and disease

Kazuki Mochizuki, Chihiro Imai, Noriko Sato, Takeo Kubota
Received: Received: June 20, 2017; Published: October 20, 2017; doi:10.21926/obm.genet.1703008