Epigenetics is Here to Stay
Abstract
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OBM Genetics
(ISSN 2577-5790)
OBM Genetics is an international Open Access journal published quarterly online by LIDSEN Publishing Inc. It accepts papers addressing basic and medical aspects of genetics and epigenetics and also ethical, legal and social issues. Coverage includes clinical, developmental, diagnostic, evolutionary, genomic, mitochondrial, molecular, oncological, population and reproductive aspects. It publishes research articles, reviews, communications and technical notes, etc. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.
Indexing:
.Archiving: full-text archived in CLOCKSS.
Rapid publication: manuscripts are undertaken in 8.5 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).
Special Issue
Epigenetic Mechanisms in Health and Disease
Submission Deadline: May 31, 2018 (Closed) Submit Now
Guest Editors
Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells
Marcel Mannens
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics
Publication
Redirecting Fetal Programming: Evidence of Interventions that May Be A Tool for Health
Abstract
Understanding the pathophysiology of disease can be an essential step to determining where and how to intervene for preventive or corrective health. Intrauterine growth restriction (IUGR) is a broad category of ailments described by low fetal weight and accompanying susceptibility to adult onset of [...]
Genetic and Epigenetic Regulation of Telomere Length: Current Findings, Methodological Limitations and Possibilities for Future Studies
by
Taylor Lawrence
and
Therese M. Murphy
Taylor Lawrence
and
Therese M. Murphy
Abstract
Telomeres are TTAGGG repeats located at the end of chromosomes that maintain DNA stability. Telomere length (TL) has been widely implicated as a marker of biological age, and is associated with several human diseases, including depression, cardiovascular disease and cancer. Twin studies and cohort s [...]
Distinct Mechanisms of Alterations in DNA Methylation/Demethylation Leading to Myelodysplastic Syndromes/Acute Myeloid Leukemia and Chronic Lymphocytic Leukemia
by
Cristina Bagacean
,
Anne Bordron
,
Adrian Tempescul
,
Jean Christophe Ianotto
,
Gaelle Guillerm
,
Wesley H Brooks
,
Marie-Anne Couturier
,
Mihnea Zdrenghea
,
Christian Berthou
and
Yves Renaudineau
Cristina Bagacean
,
Anne Bordron
,
Adrian Tempescul
,
Jean Christophe Ianotto
,
Gaelle Guillerm
,
Wesley H Brooks
,
Marie-Anne Couturier
,
Mihnea Zdrenghea
,
Christian Berthou
and
Yves Renaudineau
Abstract
Myelodysplastic syndromes (MDS) represent malignant myeloid disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). AML is a highly heterogeneous disease characterized by the presence of large chromosomal tran [...]
Evaluation of Classical Statistical Methods for Analyzing BS-Seq Data
by
Shili Lin
and
Hengrui Luo
Shili Lin
and
Hengrui Luo
Abstract
DNA methylation is an epigenetic mark that is not only important in normal cell development, but also plays a significant role in human health and diseases. As such, studies of DNA methylation to understand its precise role in disease etiology and its potential as disease biomarkers have been active [...]
Epigenetics and Infectious Disease: State-of-the-Art and Perspectives in New Generation Therapies
Abstract
Epigenetics and Infectious Disease, State of the Art and Perspectives in New Generation Therapies
Epigenetic Regulation by Androgen Receptor in Prostate Cancer
Abstract
Prostate cancer is the most commonly diagnosed cancer in men all over the world. Androgen receptor (AR) functions as a nuclear receptor to facilitate ligand-dependent transcriptional activation in the nucleus. Advanced prostate cancer is treated with androgen deprivation therapy (ADT) because androg [...]
The Induction of Histone H3K4 Methylation on the SI Gene Correlates with SI mRNA Levels in Enterocyte-Like Caco-2 Cells
Abstract
Background: Chromodomain-helicase-DNA-binding protein (CHD) 1 is Histone H3 lysine 4 (K4) methylation is thought to be important for the transcriptional activation of genes during differentiation.
Methods: mRNA and histone modification around SI gene in a small intestinal cell line Caco-2 during th [...]
Evaluation of Recent Statistical Methods for Detecting Differential Methylation Using BS-seq Data
Abstract
Whole genome profiling of differential DNA methylation between diseased and normal samples has significant implications in research to understand the role of epigenetic regulations of cells. In recent years, the development of bisulfite sequencing (BS-seq) based molecular technology has enabled the [...]
Current Evidence on the Role of Epigenetic Mechanisms in Migraine: The Way Forward to Precision Medicine
Abstract
This review explores current evidence to demonstrate that epigenetic processes contribute in migraine pathogenesis. Both basic experimental data and clinical findings will be presented and significant findings will be highlighted and discussed. Current challenges and unmet needs will also be listed.
Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions
Abstract
Suicide is the second leading cause of death globally among young people and the tenth leading cause of death across all ages. Approximately 800,000 people die by suicide every year representing a significant global health burden. Despite this burden, the molecular pathology of suicide remains poorl [...]
Histone O-GlcNAcylation and Potential Biological Functions
Abstract
Histone modifications play an important role in the control of all DNA-based processes by altering the structure and function of chromatin. An O-linked N-acetylglucosamine (O-GlcNAc) modification is a type of post-translational modification of proteins, and gets attached to serine (Ser)/threonine (T [...]
Epigenetics of IgA Nephropathy: A Brief Review
Abstract
Immunoglobin A Nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Its development is characterized by the deposition of immune complexes that consist of abnormally galactozylated IgA1 molecules and IgG or IgA autoantibodies in the mesangium and the subsequent induction of re [...]
Uniparental Disomy and Imprinting Disorders
Abstract
Uniparental disomy (UPD), the inheritance of both homologues of a chromosome from only one parent, has been reported for nearly all human chromosomes. Depending on its mode of formation and time of occurrence, UPD can be present in all cells of an organism, or restricted to some cell lines as a mosa [...]
New Insights into the Epigenetic Activities of Natural Compounds
by
Melita Vidakovic
,
Jessica Marinello
,
Maija Lahtela-Kakkonen
,
Daumantas Matulis
,
Vaida Linkuvienė
,
Benoît Y Michel
,
Ruta navakauskiene
,
Michael S Christodoulou
,
Danielle Passarella
,
Saulius Klimasauskas
,
Christophe Blanquart
,
Muriel Cuendet
,
Judit Ovadi
,
Stéphane Poulain
,
Fabien Fontaine-Vive
,
Alain Burger
and
Nadine Martinet
Melita Vidakovic
,
Jessica Marinello
,
Maija Lahtela-Kakkonen
,
Daumantas Matulis
,
Vaida Linkuvienė
,
Benoît Y Michel
,
Ruta navakauskiene
,
Michael S Christodoulou
,
Danielle Passarella
,
Saulius Klimasauskas
,
Christophe Blanquart
,
Muriel Cuendet
,
Judit Ovadi
,
Stéphane Poulain
,
Fabien Fontaine-Vive
,
Alain Burger
and
Nadine Martinet
Abstract
Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites belong to our diet and have conflictual documented epigenetic activities which need clarification.
Methods: Seventy-one different natural pro [...]
Runs of Homozygosity and Epigenetic Deregulation of Genomic Imprinting
Abstract
Runs of homozygosity (ROH) are uninterrupted continuous regions within the genome exhibiting allelic homozygosity (identical alleles are inherited from each parent). Genome-wide analyses consistently evidence that megabase-scale ROH are ubiquitous in humans reflecting individual demographic history. [...]
Epigenetic Symmetry of DLGAP2: Pre-Implantation Maternal Methylation Switches to a Random Monoallelic Profile in Somatic Tissues
by
Ana Monteagudo-Sánchez
,
Marta Sánchez-Delgado
,
Sonia Guara Ciurana
,
Jose Medrano
,
Maria Eugenia Poo-Llanillo
,
Miho Ishida
,
Gudrun Moore
,
Isabel Iglesias-Platas
,
Carlos Simón
and
David Monk
Ana Monteagudo-Sánchez
,
Marta Sánchez-Delgado
,
Sonia Guara Ciurana
,
Jose Medrano
,
Maria Eugenia Poo-Llanillo
,
Miho Ishida
,
Gudrun Moore
,
Isabel Iglesias-Platas
,
Carlos Simón
and
David Monk
Abstract
- Background
Symmetric DNA methylation profiles of autosomal genes is associated with equal expression from both alleles. Genes with an allelic imbalance or monoallelic expression are associated with discrete intervals of allele-specific methylation (ASM), as highlighted by genomic imprinting, X-chr [...]
Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Dissemination
by
Virginie Vignard
and
Delphine Fradin
Virginie Vignard
and
Delphine Fradin
Abstract
Melanoma is a highly aggressive skin cancer with high incidence worldwide. There are growing evidences that aberrantly expressed non-coding RNAs (ncRNAs) play a role in the development, progression and dissemination of melanoma tumor cells. Among the many types of ncRNAs, we will describe in this re [...]
Current Understanding of DNA Methylation and Age-related Disease
by
Eunise Martha Aquino
,
Miles C. Benton
,
Larisa M. Haupt
,
Heidi G. Sutherland
,
Lyn R. Griffiths
and
Rodney A. Lea
Eunise Martha Aquino
,
Miles C. Benton
,
Larisa M. Haupt
,
Heidi G. Sutherland
,
Lyn R. Griffiths
and
Rodney A. Lea
Abstract
DNA methylation involves the covalent transfer of a methyl group to the C-5 position of the cytosine ring on a DNA strand which can affect gene transcription. DNA methylation is both heritable and modifiable. In recent years, epigenome-wide association studies using high-throughput technologies have [...]
The Role of Epigenetics in Developmental Programming and the Developmental Origins of Health and Disease
Abstract
A number of epidemiological studies have suggested that environmental stresses, such as malnutrition during the fetal period, can induce development of metabolic disorders, such as obesity, type 2 diabetes and hypertension, and psychiatric disorders in later life. This theory is known as the Develop [...]
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