OBM Genetics

Special Issue

Epigenetic Mechanisms in Health and Disease

Submission Deadline: May 31, 2018 (Open)               Submit Now

Guest Editors

Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
E-Mail: [email protected]
Website:  http://med.unistra.fr/eng/Recherche/Liste-des-Hospitalo-Universitaires/VIVILLE
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells

Marcel Mannens, PhD
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
E-Mails: [email protected]; [email protected]
Website: https://www.amc.nl/web/research-75/person-1/prof.-dr.-m.m.a.m.-mannens.htm
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics

Planned Papers

Title: Epigenetic changes if in vitro fertilization and embryo culture in humans
Authors: Arne Sunde
Affiliations: Department of Clinical and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway

Title: Epigenetic regulation by androgen receptor in prostate cancer
Author: Ken-ichi Takayama^{1, 2}
Affiliations:
1. Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan; E-mail: [email protected]
2. Department of Geriatric Medicine, the University of Tokyo, Tokyo, Japan
Abstract
Prostate cancer is the most commonly diagnosed cancer in men all over the world. Androgen receptor (AR) functions as a nuclear receptor to facilitate ligand-dependent transcriptional activation in the nucleus. Advanced prostate cancer is treated with androgen deprivation therapy (ADT) because androgen and AR signaling drive the prostate tumor growth and anti-apoptotic ability. Resistance to ADT in most tumors develops quickly, but AR continues to be active in relapsed tumors called castration-resistant prostate cancer (CRPC). Therefore, it is important to understand AR transcriptional mechanism and downstream signaling. Recent studies have shown the central role of chromatin structure and histone modifications in determining AR-regulated genes. In addition, AR functions through interaction with several tissue-specific transcription factors such as forkhead box protein A1 (FOXA1). Interestingly, non-coding RNAs such as long non-coding RNAs (lncRNAs) and micro RNAs (miRNAs) modulate epigenetic status to promote AR function directly or indirectly and have central roles in prostate cancer progressions. The focus of this review is on the involvement of AR in epigenetic regulation in prostate cancer development and progression

Title: Epigenetics and Human Reproduction
Author: Liborio Stuppia, MD1,2
Affiliation: 1. Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
2. Center for Aging Studies and Translational Medicine (CESI-MET), G. d’Annunzio University of Chieti-Pescara, Chieti, Italy, E-Mail: [email protected]
Abstract
In the frame of the large interest recently devoted to the role played by epigenetic regulation of gene expression in human health and disease, a key point is represented by the involvement of epigenetic modifications in human reproduction, in terms of reduced fertility, abnormalities of embryo development and risk of early and late onset diseases in the offspring. In fact, epigenetic mechanisms play a key role in the control of male and female gametogenesis, and alterations in the correct organization of DNA methylation, chromatin modelling and miRNA production can affect not only the fertility of the couple, but also, by intergenerational or transgenerational effects, the health of the offspring at birth or during lifetime. A further element of variability in human reproduction is represented by the increasing use of Assisted Reproduction Techniques (ART), in turn able to induce epigenetic modifications in the embryo and increase the risk of related disorders.
In this review, we analyse the different features of the correlation between epigenetics modification and human reproduction, describing not only the risks related to alterations of the epigenetic organization in male and female gamete, but also suggesting that the reversibility of the epigenetic processes could represent a novel resource for the treatment of the infertility of the couple.

Title: Update on Epigenetics Landscape in Parkinson Disease and Lewy Body Dementia
Author: Simon Chiu
Affiliation: Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada

Title: non-coding RNAs in Melanoma development, progression and dissemination
Author: Delphine Fradin
Affiliation: Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France

Title: Similarities and differences of epigenetic mechanisms in chronic lymphocytic leukemia, myelodysplasia and acute myelod leukemia
Author: Cristina Bagacean^{1, 2, 3}, Yves Renaudineau^{1, 2, 3}
Affiliation: 1. U1227 B Llymphocytes & Autoimmunity, University of Brest, INSERM, IBSAM, Brest, France
2. Labex IGO, Networks IC-CGO & REpiCGO from ‘Canceropole Grand Ouest’, Brest, France
3. Laboratory of Immunology & Immunotherapy, Brest University Medical School Hospital, Brest, France

Title: Uniparental disomy and imprinting disorders
Authors: Thomas Eggermann, Z. Tümer, Glostrup, DK
Affiliations: Institut für Humangenetik, der RWTH Aachen, Pauwelsstr. 30 52074 Aachen, Germany

Title: Deciphering the epigenetic landscape of suicidal behaviour: a review of current findings, caveats and future directions
Author: Therese Murphy
Affiliation: Complex Disease Epigenetics Group, RILD building, Level 4, University of Exeter Medical School, Exeter, UK; Email: [email protected]
Abstract
Suicide is the second leading cause of death globally among young people and the tenth leading cause of death across all ages. Approximately 800,000 people die by suicide every year representing a significant global health burden. Despite this burden, the molecular pathology of suicide remains poorly understood. A number of recent studies have shown that epigenetic alterations are associated with suicidal behaviour. These epigenetic mechanisms, which act to regulate gene expression via modifications to DNA, histone proteins and chromatin, change with age and in response to specific environmental and psychosocial factors —providing a mechanism for the interaction between genotype and the environment. The present review briefly outlines the main epigenetic mechanisms involved in gene regulation and discusses recent findings of epigenetic alterations in suicidal behaviour, their caveats and the future direction of this emerging field of research.

Title: Functionnal Screening for DNA methylation inhibition, HDAC and sirtuin inhibition and Histone methylation (also functionnal assay) and differenciation of myeloma cells (functionnal also).
Author: Nadine Martinet
Affiliation: Institut de Chimie, UMR CNRS 7272, Universit´e de Nice-Sophia Antipolis, Parc Valrose, Nice 06108, France. E-mail: [email protected]

Title: Epigenetics in the actions of melatonin
Author: Ruediger Hardeland
Affiliation: Johann Friedrich Blumenbach Institute of Zoology and Anthropology, Universitat Gottingen, Gottingen, Germany

Title: Epigenetics of migraine
Author: Parisa Gazerani Pharm D, PhD
Affiliation: Department of Health Science and Technology, Aalborg University, Frederik Bajers Vej 7A2-A2-208, 9220 Aalborg East, Denmark; E-Mail: [email protected]

Title: Runs of homozygosity/long contiguous stretches of homozygosity (ROH/LCSH) and epigenetic deregulation of genomic imprinting
Authors: IY Iourov, prof. SG Vorsanova, prof. YB Yurov
Affiliation: Molecular Genetics and Cytogenomics of the Brain, Mental Health Research, Moscow, Russia

Title: Histone O-GlcNAcylation and its potential role
Authors: Mitsuko Hirosawa, Koji Hayakawa, Satoshi Tanaka
Affiliation: Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

Title: Nucleolar stress involvement in generation of autoantigens in autoimmune diseases
Author: Wesley H. Brooks
Affiliation: Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620, USA

Title: Epigenetics of IgA nephropathy: a brief review
Author: Stamatia Stai
Affiliation: Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

Title: Epigenetics and infectious disease, state of the art and prespectives in new generation therapies
Author: Valeria Maddaloni
Affiliation: Dip.Scienze Cardio-Toraciche e Respiratorie,  Seconda Università di Napoli, AO Monaldi, V. Leonardo Bianchi 80131, Napoli, Italy

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