Current Issue: 2019  Archive: 2018   2017  

Special Issue

Epigenetic Mechanisms in Health and Disease

Submission Deadline: May 31, 2018 (Open)               Submit Now

Guest Editors

Stéphane Viville, PhD
Professor, LABORATOIRE DE DIAGNOSTIC GENETIQUE, UF3472 – Infertilité, Nouvel Hôpital Civil,
1 place de l’Hôpital, 67091 Strasbourg cedex, France
E-Mail: [email protected]
Website:  http://med.unistra.fr/eng/Recherche/Liste-des-Hospitalo-Universitaires/VIVILLE
Research Interests: human genetics of infertility; male and female infertility; human gametogenesis; human infertility and epigenetics; embryonic stem cells

Marcel Mannens, PhD
Professor, Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
E-Mails: [email protected]; [email protected]
Website: https://www.amc.nl/web/research-75/person-1/prof.-dr.-m.m.a.m.-mannens.htm
Research Interests: genome diagnostics; epigenetics of disease; cardiogenetics

Planned Papers

Title: Epigenetics and Human Reproduction
Author: Liborio Stuppia, MD1,2
Affiliation: 1. Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, G. d’Annunzio University of Chieti-Pescara, Chieti, Italy
2. Center for Aging Studies and Translational Medicine (CESI-MET), G. d’Annunzio University of Chieti-Pescara, Chieti, Italy, E-Mail: [email protected]
Abstract
In the frame of the large interest recently devoted to the role played by epigenetic regulation of gene expression in human health and disease, a key point is represented by the involvement of epigenetic modifications in human reproduction, in terms of reduced fertility, abnormalities of embryo development and risk of early and late onset diseases in the offspring. In fact, epigenetic mechanisms play a key role in the control of male and female gametogenesis, and alterations in the correct organization of DNA methylation, chromatin modelling and miRNA production can affect not only the fertility of the couple, but also, by intergenerational or transgenerational effects, the health of the offspring at birth or during lifetime. A further element of variability in human reproduction is represented by the increasing use of Assisted Reproduction Techniques (ART), in turn able to induce epigenetic modifications in the embryo and increase the risk of related disorders.
In this review, we analyse the different features of the correlation between epigenetics modification and human reproduction, describing not only the risks related to alterations of the epigenetic organization in male and female gamete, but also suggesting that the reversibility of the epigenetic processes could represent a novel resource for the treatment of the infertility of the couple.

Title: Update on Epigenetics Landscape in Parkinson Disease and Lewy Body Dementia
Author: Simon Chiu
Affiliation: Lawson Health Research Institute, London, Ontario, N6A 4V2, Canada

Publication

Review

Redirecting Fetal Programming: Evidence of Interventions that May Be A Tool for Health

Camila Sandoval, Colleen A Lambo, Michael Carey Satterfield
Received: June 1, 2018; Published: December 28, 2018; doi:10.21926/obm.genet.1804058

Review

Distinct Mechanisms of Alterations in DNA Methylation/Demethylation Leading to Myelodysplastic Syndromes/Acute Myeloid Leukemia and Chronic Lymphocytic Leukemia

Cristina Bagacean, Anne Bordron, Tempescul Adrian, Jean Christophe Ianotto, Gaelle Guillerm, Wesley H Brooks, Marie-Anne Couturier, Mihnea Zdrenghea, Christian Berthou, Yves Renaudineau
Received: June 5, 2018; Published: December 14, 2018; doi:10.21926/obm.genet.1804054

Original Research

Evaluation of Classical Statistical Methods for Analyzing BS-Seq Data

Hengrui Luo, Shili Lin
Received: May 23, 2018; Published: December 10, 2018; doi:10.21926/obm.genet.1804053

Review

Epigenetics and Infectious Disease: State-of-the-Art and Perspectives in New Generation Therapies

Maddaloni Valeria, D’Arco Daniela, Morano Francesca, Pepe Nicola, Atripaldi Luigi
Received: May 30, 2018; Published: November 12, 2018; doi:10.21926/obm.genet.1804048

Review

Epigenetic Regulation by Androgen Receptor in Prostate Cancer

Ken-ichi Takayama
Received: May 26, 2018; Published: November 2, 2018; doi:10.21926/obm.genet.1804047

Original Research

The Induction of Histone H3K4 Methylation on the SI Gene Correlates with SI mRNA Levels in Enterocyte-Like Caco-2 Cells

Kazuki Mochizuki, Ayumi Osaki, Yuko Inamochi, Toshinao Goda
Received: December 18, 2017; Published: October 30, 2018; doi:10.21926/obm.genet.1804046

Original Research

Evaluation of Recent Statistical Methods for Detecting Differential Methylation Using BS-seq Data

Chenggong Han, Hancong Tang, Shuyuan Lou, Yuan Gao, Min Ho Cho, Shili Lin
Received: May 23, 2018; Published: October 15, 2018; doi:10.21926/obm.genet.1804041

Review

Deciphering the Epigenetic Landscape of Suicidal Behaviour: A Review of Current Findings, Caveats and Future Directions

Stefania Policicchio, Emma L Dempster, Therese M Murphy
Received: June 20, 2018; Published: October 6, 2018; doi:10.21926/obm.genet.1804039

Review

Histone O-GlcNAcylation and Potential Biological Functions

Mitsuko Hirosawa, Koji Hayakawa, Kunio Shiota, Satoshi Tanaka
Received: July 5, 2018; Published: September 19, 2018; doi:10.21926/obm.genet.1803036

Review

Epigenetics of IgA Nephropathy: A Brief Review

Stamatia Stai
Received: May 27, 2018; Published: September 7, 2018; doi:10.21926/obm.genet.1803032

Review

Uniparental Disomy and Imprinting Disorders

Thomas Eggermann, Deborah J.G. Mackay, Zeynep Tümer
Received: June 28, 2018; Published: August 30, 2018; doi:10.21926/obm.genet.1803031

Research Article

New Insights into the Epigenetic Activities of Natural Compounds

Melita Vidakovic, Jessica Marinello, Maija Lahtela-Kakkonen, Daumantas Matulis, Vaida Linkuvienė, Benoît Y. Michel, Ruta Navakauskienė, Michael S. Christodoulou, Danielle Passarella, Saulius Klimasauskas, Christophe Blanquart, Muriel Cuendet, Judit Ovadi, Stéphane Poulain, Fabien Fontaine-Vive, Alain Burger, Nadine Martinet
Received: May 30, 2018; Published: August 16, 2018; doi:10.21926/obm.genet.1803029

Opinion

Runs of Homozygosity and Epigenetic Deregulation of Genomic Imprinting

Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov
Received: May 29, 2018; Published: August 15, 2018; doi:10.21926/obm.genet.1803028

Research Article

Epigenetic Symmetry of DLGAP2: Pre-Implantation Maternal Methylation Switches to a Random Monoallelic Profile in Somatic Tissues

Ana Monteagudo-Sánchez, Marta Sánchez-Delgado, Sonia Guara Ciurana, Jose Medrano, Maria Eugenia Poo-Llanillo, Miho Ishida, Gudrun E. Moore, Isabel Iglesias-Platas, Carlos Simón, David Monk
Received: May 29, 2018; Published: July 30, 2018; doi:10.21926/obm.genet.1803026

Review

Non-Coding RNAs in Cutaneous Melanoma Development, Progression and Dissemination

Virginie Vignard, Delphine Fradin
Received: March 13, 2018; Published: May 16, 2018; doi:10.21926/obm.genet.1802020

Review

Current Understanding of DNA Methylation and Age-related Disease

Eunise M. Aquino, Miles C. Benton, Larisa M. Haupt, Heidi G. Sutherland, Lyn R. Griffiths, Rodney A. Lea
Received: February 12, 2018; Published: April 12, 2018; doi:10.21926/obm.genet.1802016

Review

The role of epigenetics in developmental programming and the developmental origins of health and disease

Kazuki Mochizuki, Chihiro Imai, Noriko Sato, Takeo Kubota
Received: June 20, 2017; Published: October 20, 2017; doi:10.21926/obm.genet.1703008

0.0452s