OBM Neurobiology is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc. By design, the scope of OBM Neurobiology is broad, so as to reflect the multidisciplinary nature of the field of Neurobiology that interfaces biology with the fundamental and clinical neurosciences. As such, OBM Neurobiology embraces rigorous multidisciplinary investigations into the form and function of neurons and glia that make up the nervous system, either individually or in ensemble, in health or disease. OBM Neurobiology welcomes original contributions that employ a combination of molecular, cellular, systems and behavioral approaches to report novel neuroanatomical, neuropharmacological, neurophysiological and neurobehavioral findings related to the following aspects of the nervous system: Signal Transduction and Neurotransmission; Neural Circuits and Systems Neurobiology; Nervous System Development and Aging; Neurobiology of Nervous System Diseases (e.g., Developmental Brain Disorders; Neurodegenerative Disorders).

OBM Neurobiology publishes research articles, technical reports and invited topical reviews. Although the OBM Neurobiology Editorial Board encourages authors to be succinct, there is no restriction on the length of the papers. Authors should present their results in as much detail as possible, as reviewers are encouraged to emphasize scientific rigor and reproducibility.

Free Publication in 2019

Open Access Case Report

Changes in SPECT Brain Imaging in Pediatric Patients with Suspected Neuroborreliosis: A Series of 6 Cases

Laura Alonso Canal, Cecilia Paredes Mercado, María José Quiles Blanco, Marco Motta Calderón
Received: April 01, 2019; Published: May 14, 2019; doi:10.21926/obm.neurobiol.1902028

Abstract: Lyme disease is a disease transmitted by ticks with a broad spectrum of comorbidity associated, from purely osteoarticular to neurological, as well as great variability comorbidity depending on the age of the individual. It currently represents an epidemic recognized by the CDC and confers a very i [...]

Open Access Review

Connections between Early-Life Neuroinflammation, Neural Stem Cells and Progenitors and Origins of Neuropsychiatric Disorders

Ekta Kumari, Fernando J. Velloso, Steven W. Levison
Received: February 13, 2019; Published: May 13, 2019; doi:10.21926/obm.neurobiol.1902027

Abstract: A number of studies have highlighted the connection between infections during pregnancy in mothers and increased risk for neuropsychiatric disorders later in life leading to the view that maternal immune activation is a significant contributor to psychiatric illnesses. Meta-analyses have revealed a [...]

Open Access Review

The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

Paul D. Loprinzi
Received: March 30, 2019; Published: May 10, 2019; doi:10.21926/obm.neurobiol.1902026

Abstract: Objective: The objective of this paper was to evaluate the extent to which exercise may influence long-term potentiation (LTP), a key cellular correlate of episodic memory function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Sch [...]

Open Access Editorial

Editorial: “A New Era in Neuro-Oncology”

Antonio Meola
Received: May 05, 2019; Published: May 08, 2019; doi:10.21926/obm.neurobiol.1902025

Open Access Research Article

Gluten-Free Diet for the Treatment of ADHD; Pilot Study

Laura Alonso Canal, Inmaculada Carreras Sáez, María Concepción Fournier del Castillo, Julia Asensio Antón, Inmaculada de Prada Vicente, Carlos Isasi Zaragoza, Javier Tejada Gallego, María José Martínez Gómez
Received: December 17, 2018; Published: April 03, 2019; doi:10.21926/obm.neurobiol.1902024

Abstract: Aim: The association between Attention deficit hyperactivity disorder (ADHD) and celiac disease has already been established. Non-celiac gluten sensitivity (NCGS), as well as celiac disease, has been associated with neuro-psychiatric disorders. Our objective is to assess if a proportion of pediatric [...]

Open Access Review

Ischemic Brain Injury and Regulatory T Cells

Minako Ito, Tanakorn Srirat, Toshihiro Nakamura, Kyoko Komai, Akihiko Yoshimura
Received: January 13, 2019; Published: March 27, 2019; doi:10.21926/obm.neurobiol.1901023

Abstract: Inflammation and immune responses after stroke including ischemic cerebral infarction play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues [...]

Open Access Review

Diffuse Intrinsic Pontine Glioma: Translation of Genomic Knowledge to Clinical Practice

Tina Zhou, Sara Khan, Ron Firestein, Peter Downie, Jason E Cain
Received: November 29, 2018; Published: March 12, 2019; doi:10.21926/obm.neurobiol.1901022

Abstract: Pediatric brain tumors account for approximately 25% of all cancers in children and are currently the leading cause of cancer-related deaths in the pediatric population with an estimated incidence of 5.14 cases per 100,000 persons [1]. Up to 10-15% of all pediatric brain tumors arise in the brainste [...]

Open Access Review

Sporadic and Hereditary Hemangioblastoma: The Role of Endothelial Cells

Alberto Feletti, Elena Bianchini, Anna De Gaetano, Lara Gibellini, Sara De Biasi, Giacomo Pavesi, Anna Vittoria Mattioli, Milena Nasi, Andrea Cossarizza, Marcello Pinti
Received: November 26, 2018; Published: March 04, 2019; doi:10.21926/obm.neurobiol.1901021

Abstract: Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. About 75% of HBs are sporadic, while 25% are associated with von Hippel-Lindau (VHL) disease. HBs consist of two main components, a rich capillary network composed of vascular endothelia and pericytes, with [...]

Open Access Research Article

Magnetic Resonance Imaging Approaches for Predicting the Response to Hyperoxic Radiotherapy in Glioma-Bearing Rats

Nuria Arias-Ramos, Jesús Pacheco-Torres, Pilar López-Larrubia
Received: November 11, 2018; Published: January 31, 2019; doi:10.21926/obm.neurobiol.1901020

Abstract: Background: Despite the advances in multimodal therapeutic options, glioblastoma (GBM), the most frequent and aggressive of all astrocytomas, remains with a median survival of 15 months. It is reported a direct correlation between GBM hypoxia and a higher aggressiveness, poor prognosis and greater r [...]

Open Access Research Article

Correlation of CT and MR Perfusion and Permeability Parameters for Intracranial Tumors

Kirsten Greenlaw, Jai Jai Shiva Shankar
Received: October 7, 2018; Published: January 14, 2019; doi:10.21926/obm.neurobiol.1901019

Abstract: Background and Purpose: Perfusion imaging, mainly MR perfusion (MRP), is performed frequently for brain tumor imaging. CT perfusion (CTP) is less studied as a method for characterizing brain tumors. The purpose of this study was to demonstrate the usefulness of CTP perfusion parameters in evaluating [...]

Open Access Case Report

Cerebellopontine Angle Glioblastoma with Concurrent Spinal Cord Involvement: A Case Report and Review of Literature

Rahul Abhyankar, Divya Mella, Edward Pan
Received: November 12, 2018; Published: January 4, 2019; doi:10.21926/obm.neurobiol.1901018

Abstract: Objective: To report a unique case of cerebellopontine angle glioblastoma with concurrent spinal cord involvement. Background: Glioblastoma (GBM) is the most common primary malignancy of the central nervous system (CNS), comprising 46.6% of all CNS malignancies. By anatomic location, cerebelloponti [...]

Open Access Review

Sleep Disorders in Children with Central Nervous System Tumors

Melissa A. Maloney, Katherine E. Lewinter, Sally L. Davidson Ward, Iris A. Perez
Received: November 13, 2018; Published: December 17, 2018; doi:10.21926/obm.neurobiol.1804017

Abstract: Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hy [...]

Open Access Original Research

TTF-1-Expressing Supratentorial Embryonal Tumors (PNET): A Clinicopathologic Study of Two Cases and Literature Review of TTF-1-Positive Primary Brain Tumors

Michele Bisceglia, Stefano Pizzolitto, Tullio Parracino, Giovanna De Maglio, Elena Minenna, Serena D’Agostini, Carlos A. Galliani
Received: October 7, 2018; Published: November 14, 2018; doi:10.21926/obm.neurobiol.1804016

Abstract: Thyroid transcription factor 1 (TTF-1) is a nuclear polypeptide, tissue-restricted member of the homeobox protein family, that when attached to DNA plays a crucial role in regulating the expression of select genes during early embryonic development of the thyroid, lung, and brain. As often happens, [...]

Open Access Review

Angiocentric Glioma: A Review of Clinicopathologic Features

Richard A. Prayson, MD, MEd
Received: September 4, 2018; Published: November 5, 2018; doi:10.21926/obm.neurobiol.1804015

Abstract: Along with focal cortical dysplasia, hippocampal sclerosis and remote infarcts, tumors are a well known cause of medically intractable or pharmacoresistent epilepsy [1-3]. Most of the tumors encountered in this setting represent low grade glioneuronal neoplasms, particularly gangliogliomas and dyse [...]

Open Access Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Divya B. Mella, Josie Sewell, Edward Pan
Received: October 12, 2018; Published: October 31, 2018; doi:10.21926/obm.neurobiol.1804014

Abstract: Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent us [...]

Open Access Research Article

Isolated Diffusion Restriction Preceding Contrast Enhancement in Glioblastoma Multiforme is Associated with Short-Term Survival

Jai Jai Shiva Shankar, Adil Bata, Namita Sinha
Received: August 7, 2018; Published: October 26, 2018; doi:10.21926/obm.neurobiol.1804013

Abstract: Background: Current imaging standard for detecting and assessing glioblastoma multiforme (GBM) progression depends on contrast-enhancement on brain magnetic resonance imaging (MRI). Isolated foci of diffusion restriction have been observed to precede enhancement in GBM. The aim of our study was to i [...]

Open Access Review

Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Concepts

Ruth Prieto, José M Pascual
Received: September 11, 2018; Published: October 16, 2018; doi:10.21926/obm.neurobiol.1804012

Abstract: Treatment of craniopharyngiomas (CPs) represents a neurosurgical challenge, the major reason being their close relationship with the hypothalamus and the third ventricle (3V) boundaries. Nevertheless, CPs are generally defined as “suprasellar” lesions, an imprecise and frequently faulty term. Despit [...]

Open Access Review

Contribution of PET Imaging to Clinical Management of Gliomas

Wolf-Dieter Heiss
Received: July 2, 2018; Published: September 20, 2018; doi:10.21926/obm.neurobiol.1803011

Abstract: Gliomas originating from glial cells, comprise about 30 % of all primary central nervous system tumors and 80 % of malignant brain tumors. Gliomas are different with respect to their biological activity and are categorized according to grades, from benign to malignant with high recurrence rates. For [...]

Open Access Original Research

Haplo-Insufficiency or Knockout of the Serotonin Transporter Does not Affect Heroin Self-Administration but Decreases BDNF in the Frontal Cortex

Bridget W. Brox, Darren J. Day, Bart A. Ellenbroek
Received: February 1, 2018; Published: June 12, 2018; doi:10.21926/obm.neurobiol.1802010

Abstract: (1) Background: Drug addiction places a heavy burden on those affected by it but only a small percentage of individuals (~20%), regardless of their drug of abuse, go on to develop the compulsive behaviours that define drug addiction. Clinical studies have shown that genetic variations that reduce se [...]

Open Access Review

Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic Dysfunction

Gina Sizemore, Brandon Lucke-Wold, Charles Rosen, James W. Simpkins, Sanjay Bhatia, Dandan Sun
Received: January 12, 2018; Published: June 1, 2018; doi:10.21926/obm.neurobiol.1802009

Abstract: The brain is an integrated network of multiple variables that when compromised creates a disease state. The neuropathology of temporal lobe epilepsy, stroke, and traumatic brain injury demonstrate both similarity and complexity that reflects this integrated variability; temporal lobe epilepsy with i [...]

Open Access Editorial

The Translational Umbrella - A Novel Approach to the Study of the Biological Basis of Mental Health

Bart A. Ellenbroek, Weiwen Wang
Received: March 20, 2018; Published: March 29, 2018; doi:10.21926/obm.neurobiol.1801008

Abstract: None

Open Access Editorial

Mitochondria, Brain, Heart and Body

Ya Wen
Received: November 28, 2017; Published: December 5, 2017; doi:10.21926/obm.neurobiol.1704007

Abstract: More and more studies revealed links amongst neurological disorders, heart diseases and cancers. For example, people with subclinical cardiovascular diseases are at higher risk for Alzheimer's disease, Parkinson’s disease is associated with varied risk of cancer, Autism Spectrum Disorders and cancer [...]

Open Access Review

Perspective on Neurobiological and Clinical Early Indicators of Mild Cognitive Decline and Alzheimer’s Disease

Jigar Jogia
Received: April 16, 2017; Published: July 10, 2017; doi:10.21926/obm.neurobiol.1702006

Abstract: There is a need for early diagnosis, monitoring and treatment of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Traditional assessments of cognitive decline have been found to lack sensitivity and accuracy in differentiating varying stages of Demetria and cognitive decline as well as [...]

Open Access Review

Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders

Mason L. Yeh , Eric S. Levine
Received: April 11, 2017; Published: April 27, 2017; doi:10.21926/obm.neurobiol.1702005

Abstract: Autism spectrum disorders (ASDs) are diagnosed on the basis of three behavioral features, namely, (1) deficits in social communication, (2) absence or delay in language and (3) stereotypy. The consensus regarding the neurological pathogenesis of ASDs is aberrant synaptogenesis and synapse function. [...]

Open Access Review

A Neurodevelopmental Perspective for Autism-Associated Gene Function

Jessie Poquérusse, Bryan W. Luikart
Received: April 10, 2017; Published: April 25, 2017; doi:10.21926/obm.neurobiol.1702004

Abstract: Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes will shed light onto the neurodevelopmental basis of ASD. Here, we defined functional categories repr [...]

OBM Neurobiology welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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