OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 7 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Open Access Editorial

Liver Transplantation in Pediatrics

Yasuhiko Sugawara
Received: May 15, 2020; Published: May 18, 2020; doi:10.21926/obm.transplant.2002111

Open Access Review

Multidrug-Resistant Bacterial Infections before and after Liver Transplantation

Alberto Ferrarese, Marco Senzolo, Patrizia Burra
Received: March 29, 2020; Published: May 18, 2020; doi:10.21926/obm.transplant.2002110

Abstract: Bacterial infection represents a common event in the natural history of cirrhosis, especially in patients with end-stage liver disease. An episode of bacterial infection may significantly modify a patient’s outcome in the setting of liver transplantation (LT) by impairing hepatic and extrahepatic or [...]

Open Access Original Research

Donor Age and Ischemia Time Are Independent Factors Affecting Graft Survival after En Bloc Kidney Transplantation from Donors Less than Three Years of Age

Antoine Buemi, Jérôme Duisit, Flora Musuamba, Tom Darius, Martine De Meyer, Selda Aydin, Nada Kanaan, Arnaud Devresse, Eric Goffin, Michel Mourad
Received: January 13, 2020; Published: May 13, 2020; doi:10.21926/obm.transplant.2002109

Abstract: This study aimed to investigate the outcomes of transplantation from donors aged less than three years in a single-center consecutive series. A total of 52 en bloc kidney graft transplantations were performed. In 22 cases, organs were procured from donors aged less than one year (group 1). In 30 cas [...]

Open Access Review

Clinical Approach to the Management of Infections before and after Liver Transplantation

Anita Verma, Anil Dhawan
Received: February 14, 2020; Published: May 11, 2020; doi:10.21926/obm.transplant.2002108

Abstract: The infectious complications before and after liver transplant (LT) are affected by the severity of liver disease and immunosuppression intensity after transplantation. Both cirrhosis and immunosuppression contribute to dysfunction of defensive mechanisms of the host. When a patient is evaluated for [...]

Open Access Review

Genomic Biomarker Surveillance in the Care of Solid Organ Transplant Recipients: An Update for the General Clinician during the Coronavirus (CoVid-19) Pandemic

Allison Ramsey, Christine Natori, Kristen Cisneros, David J. Ross, Abbas Ardehali
Received: March 27, 2020; Published: May 06, 2020; doi:10.21926/obm.transplant.2002107

Abstract: Biomarker surveillance after solid organ transplant is an advancing field with promise for further elucidation through high-throughput analyses and “omics” technologies. To date, Gene Expression Profiling (GEP; AlloMapâ) is the only FDA-cleared genomic assay as surveillance for moderate-severe TCMR [...]

Open Access Editorial

Challenges to Transplantation by the Assault of CoVid-19: Emergence of Molecular Diagnostics as Surveillance

David J. Ross
Received: March 27, 2020; Published: March 31, 2020; doi:10.21926/obm.transplant.2001106

Open Access Case Report

Pediatric Mixed Left Ventricular Non-Compaction and Restrictive Cardiomyopathy Bridged to Heart Transplant with Ventricular Assist

Adam K. Morrison, Robert J. Gajarski, Ashley Hodge, Sara Fitzgerald-Butt, Peter Baker, Patrick M. McConnell, Deipanjan Nandi
Received: May 21, 2019; Published: March 26, 2020; doi:10.21926/obm.transplant.2001105

Abstract: Left ventricular noncompaction cardiomyopathy (LVNC) is a rare form of heritable cardiomyopathy with wide genotypic variability, numerous phenotypic variations, and a wide spectrum of clinical disease from asymptomatic to end stage heart failure. Here, we present a case of a 2-year-old b [...]

Open Access Review

Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance

Victoria Rendell, Natalie M. Bath, Todd V. Brennan
Received: May 09, 2019; Published: March 10, 2020; doi:10.21926/obm.transplant.2001104

Abstract: Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize “for the discovery of acquired immunologic tolerance” and eventually made organ transplantation a reality. However, [...]

Open Access Review

Histoplasmosis in Liver Transplant Recipients: Case Reports and a Review of the Literature

Amy Spallone, Udit Dhal, Laila Woc-Colburn, Marion Hemmersbach-Miller
Received: October 21, 2019; Published: February 28, 2020; doi:10.21926/obm.transplant.2001103

Abstract: We report two cases of histoplasmosis in orthotopic liver transplant (OLT) recipients to illustrate the variable presentations, complications encountered during treatment, the spectrum of diagnostic modalities, and case outcomes. Case 1 describes the insidious presentation of presumed gastrointestin [...]

Open Access Research Article

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

Muayad Alali, Michael Z. David, Sandra A. Ham, Danziger-Isakov LA, Allison H. Bartlett, Lindsay Petty, Jennifer C. Pisano
Received: November 27, 2019; Published: February 21, 2020; doi:10.21926/obm.transplant.2001102

Abstract: Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers reso [...]

Open Access Review

Hematopoietic Stem Cell Transplantation in Refractory Celiac Disease: An Overview with Focus on Infectious Complications

Abdulbaqi Al-Toma, Harry R. Koene
Received: December 16, 2019; Published: February 18, 2020; doi:10.21926/obm.transplant.2001101

Abstract: Refractory celiac disease (RCD) is a rare condition in which a known celiac patient, usually an adult, suffers from persistence or recurrence of gluten-related symptomatology, laboratory abnormalities, and inflammatory enteropathy despite following an optimal dietary therapy with gluten-free diet (G [...]

Open Access Editorial

Transplantation of a Kidney with an Extra-Renal Organ

Steven R. Potter
Received: February 10, 2020; Published: February 13, 2020; doi:10.21926/obm.transplant.2001100

Open Access Original Research

Eplet-Based HLA Class II Matching for Transplantation: Design of a Repertoire of Interlocus Eplets Shared between HLA-DR, -DQ and -DP Alleles

Rene J. Duquesnoy, Marilyn Marrari
Received: December 13, 2019; Published: February 11, 2020; doi:10.21926/obm.transplant.2001099

Abstract: Many studies have demonstrated that HLA-DR, HLA-DQ and HLA-DP matching at the eplet level reduces allograft rejection and improves transplant outcome. Such studies have examined the eplet effect for the individual class II loci, but until now little attention has been given to so-called interlocus c [...]

Open Access Review

Utility of Fungal Cell Markers in Pediatric Bone Marrow Transplant Recipients for Screening and Diagnosis of Invasive Fungal Infections

Nour Hasan, Ankita P. Desai, Jignesh Dalal
Received: November 12, 2019; Published: February 03, 2020; doi:10.21926/obm.transplant.2001098

Abstract: Invasive fungal disease (IFD) is a significant contributor to morbidity and mortality in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT). Early detection and timely initiation of antifungal therapy is important for improved outcome, but diagnosis remains difficult, espec [...]

Open Access Editorial

Immunosuppression in Kidney Transplantation

Maurizio Salvadori, Aris Tsalouchos
Received: January 19, 2020; Published: February 03, 2020; doi:10.21926/obm.transplant.2001097

Abstract: Immunosuppressive therapy in renal transplantation is divided into two phases as induction and maintenance therapy. Induction therapy is an intense immunosuppressive therapy administered at the time of kidney transplantation to reduce the risk of acute allograft rejection. In general, induction immu [...]

Open Access Case Report

Dual Kidney Transplantation after Hypothermic Oxygenated Perfusion from Marginal Donor after Circulatory Death with Acute Kidney Injury: A Case Report

Federica Odaldi, Vanessa De Pace, Giacomo Frascaroli, Giuliana Germinario, Giorgia Comai, Francesco Vasuri, Gaetano La Manna, Matteo Ravaioli
Received: November 22, 2019; Published: February 03, 2020; doi:10.21926/obm.transplant.2001096

Abstract: Donation after circulatory death (DCD) is an increasingly used resource to alleviate chronic renal graft shortages. Organs from donors with progressively increased creatinine levels due to acute kidney injury are used, but the effects of this condition on kidney transplantation are still unclear. Ex [...]

Open Access Research Article

Long-Term Exposure to Fine Particulate Matter (PM2.5) and Cardiovascular Disease Mortality among Renal Transplant Recipients

Salem Dehom, Synnove Knutsen, David Shavlik, Khaled Bahjri, Hatem Ali, Lance Pompe, Rhonda Spencer-Hwang
Received: August 11, 2019; Published: December 17, 2019; doi:10.21926/obm.transplant.1904095

Abstract: Background: Substantial evidence has been used to establish links between air pollution and increased risks of overall health morbidity and mortality, especially for respiratory and cardiovascular diseases. However, very few investigations have explored these relationships among highly sensitive pop [...]

Open Access Review

Modelling Recurrent Primary Biliary Cholangitis and Primary Sclerosing Cholangitis as Infectious Diseases Following Liver Transplantation

Victor Dong, Aldo J. Montano-Loza, Andrew L. Mason
Received: November 19, 2019; Published: December 13, 2019; doi:10.21926/obm.transplant.1904094

Abstract: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are idiopathic and progressive autoimmune hepatobiliary disorders that lead to liver failure and a need for liver transplantation in a proportion of individuals with poorly controlled disease. It is currently thought that an [...]

Open Access Review

Therapeutic Apheresis in Prevention and Treatment of Antibody-Mediated Rejection of Renal Allografts

Maurizio Salvadori, Aris Tsalouchos
Received: October 13, 2019; Published: December 02, 2019; doi:10.21926/obm.transplant.1904093

Abstract: Antibody-mediated rejection represents a significant barrier to favourable long-term outcomes after kidney transplantation and is the most common cause of allograft failure. Therapeutic apheresis techniques associated with other treatments, such as immunosuppressive drugs, are commonly used in the p [...]

Open Access Research Article

Incidence, Location, and Natural History of Perihepatic Fluid Collections after Orthotopic Liver Transplantation

Sumail Bhogal, Matthew Minn, Pranay Krishnan, Reena C. Jha
Received: February 18, 2019; Published: November 18, 2019; doi:10.21926/obm.transplant.1904092

Abstract: Objective: The purpose of this study was to evaluate the common locations of perihepatic fluid collections after liver transplantation, assess their complexity, and understand their natural history and clinical significance. Materials and Methods: A retrospective analysis of 189 postoperative ortho [...]

Open Access Case Report

Toxoplasmosis: “An Often Forgotten Cause for Fever of Unknown Origin in Liver Transplant Recipients”. Case Report and Review of Literature

Jose A. Morillas, Sherif Beniameen Mossad
Received: October 24, 2019; Published: November 18, 2019; doi:10.21926/obm.transplant.1904091

Abstract: Toxoplasmosis in liver transplantation (LT) is uncommon, especially in the current era of universal prophylaxis with trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jirovecii pneumonia (PJP). Here we present a case of a 55-year-old woman LT recipient, on dapsone or PJP prophylaxis due to su [...]

Open Access Original Research

Combination, Sequential Therapies Incorporating Tocilizumab Decrease the Progression of Chronic Lung Allograft Dysfunction (CLAD) after Lung Transplantation: Initial Clinical Experience

David J. Ross, Abbas Ardehali, Christine Natori, John A. Belperio 
Received: September 19, 2019; Published: November 07, 2019; doi:10.21926/obm.transplant.1904090

Abstract: INTRODUCTION: TH-17 and IL-6 interactions and detrimental biologic effects have been shown in rodent models of Chronic Lung Allograft Dysfunction (CLAD). Similarly, these pathways have been found to be upregulated in human CLAD. Tocilizumab (TCZ), a humanized monoclonal antibody targets the IL-6 r [...]

Open Access Case Report

A Silent and Very Early Post-Liver Transplant Death by Candida Arteritis

Kyungmin Ko, Juan F. Guerra, David F. Garvin
Received: August 29, 2019; Published: October 28, 2019; doi:10.21926/obm.transplant.1904089

Abstract: Background: Graft site candidiasis is a serious complication after solid organ transplantation, often presenting as invasive arteritis leading to graft loss or even death. Case Report: We report a case of anastomotic site candidiasis leading to arterial rupture and death at postoperative day 10 with [...]

Open Access Original Research

Oral Management in Pre-HSCT Patients: An Evaluation of Oral and Systemic Complications

Renato Pol, Tiziana Ruggiero, Luisa Giaccone, Davide Camisassa, Andrea Spadafora, Giulia Rivetti, Marta Bezzi, Stefano Carossa
Received: June 14, 2019; Published: October 23, 2019; doi:10.21926/obm.transplant.1904088

Abstract: Objective Hematopoietic stem cell transplant has to be preceded by chemotherapy and radiotherapy. The following neutropenia and thrombocytopenia could be the cause of post transplant complications. Patient undergoing transplantation need to be eradicated of any possible infectious focus. Nowadays th [...]

Open Access Case Report

The Surgical Approach for Obtaining Abdominal Wall Closure in Renal Transplant Recipients with Temporary or Permanent Loss of Fascial Integrity Following Emergency Reoperative Surgery

Susanna Lam, Jerome M Laurence, Deborah J Verran
Received: July 01, 2019; Published: October 08, 2019; doi:10.21926/obm.transplant.1904087

Abstract: A range of corrective surgical procedures may be required in adult renal transplant recipients who sustain loss of integrity of the abdominal wall in the first month postoperatively. Where this involves the fascia, such as in acute fascial dehiscence or in renal allograft compartment syndrome, more [...]

OBM Transplantation welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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Highly Accessed Articles

Research Article

by Scott A. Campbell et al.

OBM Transplantation 2020

Published: 26 June 2019

Original Research

by Gopalakrishnan Loganathan et al.

OBM Transplantation 2020

Published: 24 May 2019

Research Article

by Darren Stewart et al.

OBM Transplantation 2020

Published: 22 January 2019

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