Osamu Yokosuka is an Emeritus Professor of Chiba University, Japan. He graduated from Chiba University School of Medicine in 1975 then worked as a trainee under Professor K. Okuda in Chiba University Hospital till 1978. Dr. Yokosuka was a research fellow worked under Professor S. Scherlock and Professor B. H. Billing in Royal Free Hospital, London, UK from 1978 to 1980; under Professor M. Omata in Chiba University from 1980 to 1985; and under Dr. J Summers in Fox Chase Cancer Center, PA, USA in 1984. In 1985, he received a Degree of Doctor of Medical Science, and served as an Assistant Professor in Chiba University till 1994, then as Lecturer in Medicine till 2006 when he was appointed as Director and Professor of Medicine. From 2013 to 2015, he served as the Dean of Chiba University School of Medicine.
Dr. Yokosuka was the Secretary General of APASL (2008-2014). In 2016, he was elected as the President of APASL Tokyo, the President of 52nd Annual Meeting of Japan Society of Hepatology, and the President of Funabashi Central Hospital. Dr. Yokosuka’s research mainly focuses on Hepatitis and Hepatocellular Carcinoma. So far, he has published more than 700 original papers.
Tatsuo Kanda received a medical degree in 1991 at Niigata University School of Medicine, Japan, and his PhD in 1999 at Chiba University Graduate School of Medicine, Japan. He had post-doctor training for 3 years under Prof. Ratna Ray and Prof. Ranjit Ray at Saint Louis University, St. Louis, MO, USA. In Dec. 2008, Tatsuo Kanda became a Tenure-track Associate Professor at Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan. In Feb. 2013, Tatsuo Kanda was nominated a permanent Associate Professor at Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Japan. In 2017, Tatsuo Kanda became an Associate Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine. For ~25 years, he has focused his scientific interests on the topics related to liver diseases including acute liver failure, viral hepatitis and autoimmune liver diseases, and worked with Prof. Osamu Yokosuka. Tatsuo Kanda is also an expert for hepatitis A virus (HAV), HBV and HCV, and translation and replication of these viruses, and hepatocarcinogenesis. With his expertise in antiviral therapies and hepatitis virus research, Tatsuo Kanda also sees a lot of patients in clinical daily practice. Tatsuo Kanda has published more than 200 articles in peer-reviewed Journal.
Applications of Fluorescence in Situ Hybridization
Submission Deadline: July 31, 2018 (Open) Submit Now
Thomas Liehr, PhD, Dr.h.c., inv. Prof. (YSU and BMS)
About This Topic
Fluorescence in situ hybridization (FISH) is an approach applied and applicable in many fields of biological research and diagnostics. Its unique feature is to provide information on localization and copy numbers of specific stretches of nucleic acids on the single cell level. Thus, FISH cannot be replaced by, like in medical field at present very popular ‘high throughput approaches’, which are mostly providing information on the genetic content of thousands to millions of cells at a time. FISH provides multiple possibilities and variants, according to the question to be answered. Fluorescence in situ hybridization can be applied as (i) single to multi-color FISH approaches, (ii) using DNA, RNA, cDNA, PNA, and other types of labeled nucleotides as probes; also (iii) samples for FISH can be various human, animal or plant derived tissue types, and even single cellular organisms.
In this special issue of OBM Genetics, we have selected topics that highlight the progress, the state-of–the-art and future potential of fluorescence in situ hybridization, ranging from practical and technological aspects to applications in research and diagnostics of fluorescence in situ hybridization in human, animal, plant, fungi, biofilms and bacteria. Overall this issue provides information where and how fluorescence in situ hybridization can be applied in practice, and shows its high potential in diagnostics and research.
Title:Murine multicolor banding in solid tumor cell lines
Title: Interphase Fluorescence in Situ Hybridization on products of conception
Title: Characteristics of prenatal diagnosis by FISH in Cuba
Title: Molecular diagnosis (FISH) of patients with neurodevelopmental disorders
Title: Identification of a supernumerary marker chromosome involving 11p14.1q22.1 region in a prenatal case: clinical and molecular characterization.
Title: FISHing for an unstable cellular genome in the human brain
Title: FISH-based approaches for detecting mosaic aneuploidy
Title: Interphase quantitative FISH (IQ-FISH): implications for chromosome instability analysis
Title: Molecular studies detected an original complex karyotype involving a KMT2A gene rearrangement in an infant with mixed lineage acute leukemia
Title: Potential of Interphase-FISH to Evaluate Epithelial Growth Factor Receptor of MDA-MB-231 Cell line Treated with Lapatinib and Herceptin
Title: sSMC characterization in a male with Turner syndrome stigmata
Title: Comparative Karyotype Analysis of Cardinalfishes (Perciformes, Apogonidae) in Thailand by Classical Cytogenetic and FISH Techniques
Title: Myelodysplastic syndrome with complex chromosomal rearrangement: about an observation and review of the literature
Title: Constitutional partial proximal trisomy 14q21: about two new Moroccan cases and review of the literature
Title: In silico detection and FISH location of miRNAs in Solea senegalensis chromosomes usisng BACs
Title: A case study of in vitro and in vivo karyotype evolution in melanoma using M-FISH
Title: Fluorescence In Situ Hybridisation (FISH) is a useful tool in the detection of hypodiploidy in paediatric Acute Lymphoblastic Leukaemia (ALL)
Title: Colocalization of telomeric sequences and rDNA revealed by dual-FISH
Title: Application of 3D-(Immuno)-FISH for the study of DNA replication timing of genetic repeat elements
Title: Quality Assurance/Quality Control of Fluorescence in Situ Hybridization tests in Hematologic Malignancies
Title: Optimized Tools for Detection of Numerical Chromosome Aberrations Involving Chromosome 16 in Recurrent Pregnancy Complications