OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 6 days from acceptance to publication (median values for papers published in this journal in the first half of 2020, 1-2 days of FREE language polishing time is also included in this period). A first decision provided to authors of manuscripts submitted to this journal are approximately 3.7 weeks (median values) after submission.

Current Issue: 2020  Archive: 2019 2018 2017

Special Issue

Diagnosis and Management of Infections in Solid Organ Transplant Recipients

Submission Deadline: October 30, 2018 (Open) Submit Now

Guest Editor

Maricar Malinis, MD FACP, FIDSA

Assistant Professor of Medicine and Surgery (Transplant), Medical Director, Transplant Infectious Diseases, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA;
Department of Surgery (Transplant), Yale School of Medicine, New Haven, CT, USA
Tel.: 203 785 3561

Website | E-Mail

Research Interests: Aging; Cytomegalovirus; Fungi; HIV; Transplantation; Immunocompromised host; Transplant infectious diseases

About This Topic

Solid organ transplantation is an established life -saving therapy for end-organ diseases of the kidney, liver, heart, and lungs. The improved patient and graft survivals have been attributed to advancements in surgical techniques and effective immunosuppressive therapies. However, immune suppression, pre-existing co-morbidities, and potential surgical complications can result in infectious complications after organ transplantation. In this particular issue of OBM transplantation, solicited articles will focus on review of current approaches to the diagnosis and management of post-transplant infections in solid organ transplant recipients due to bacterial, viral and fungal pathogens. Each article will also address strategies of screening and prevention of post-transplant infections.

Publication

Open Access Review

Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Received: 05 April 2019;  Published: 26 July 2019;  doi: 10.21926/obm.transplant.1903075

Abstract

The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for a dimorphic life cycle, a specific geographic distribution, and typical infection via environmental exposure. Their nonspecific presentation, often mimicking othe [...]
Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Received: 14 February 2019;  Published: 17 June 2019;  doi: 10.21926/obm.transplant.1902066

Abstract

In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]
Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Received: 18 February 2019;  Published: 10 June 2019;  doi: 10.21926/obm.transplant.1902065

Abstract

Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]
Open Access Case Report

Secondary Antibody Deficiency in a Heart Recipient with Systemic Aspergillosis

Received: 23 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.transplant.1901058

Abstract

Secondary antibody deficiency has been associated with risk of invasive fungal infections in solid organ transplantation. Single center, multicenter and metanalysis studies have tested this association. Therapy of these infectious complications in the presence of a secondary antibody deficiency afte [...]
Open Access Review

Role of Procalcitonin in Management of Infection in Solid Organ Transplantation Recipients: Review

Received: 23 December 2018;  Published: 01 March 2019;  doi: 10.21926/obm.transplant.1901054

Abstract

Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation [...]
Open Access Review

New Frontiers in Solid Organ Transplantation from Donors with Human Immunodeficiency Virus, Hepatitis C Virus Infection, and Multidrug Resistant Organisms

Received: 26 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.transplant.1901050

Abstract

Despite the advances that have been made in the field of solid organ transplantation (SOT), organ shortage remains a persistent problem and continues to worsen. In addition, the donor pool has been changing with the increase in drug overdose deaths each year with the ongoing opioid epidemic More d [...]
Open Access Review

Tuberculosis Screening and Treatment in Solid Organ Transplantation

Received: 18 November 2018;  Published: 12 February 2019;  doi: 10.21926/obm.transplant.1901048

Abstract

Background: Tuberculosis (TB) is a common infection with challenges in diagnosis and treatment. Management of TB in solid organ transplant (SOT) candidates and recipients poses unique challenges not seen in other populations. Questions and recommendations: Latent TB infection (LTBI) is important to [...]
Open Access Review

Challenges in Diagnosis and Management of Nontuberculous Mycobacteria in Solid Organ Transplantation

Received: 30 November 2018;  Published: 01 February 2019;  doi: 10.21926/obm.transplant.1901047

Abstract

Non-tuberculous mycobacteria (NTM) infections are relatively rare but carry significant morbidity in solid organ transplant (SOT) recipients. Given the rarity of disease and diagnostic limitations, a high index of suspicion is required for accurate diagnosis and initiation of appropriate treatment. [...]
Open Access Perspective

Solid Organ Transplantation in Older Adults. Infectious and Other Age-Related Considerations

Received: 30 November 2018;  Published: 01 February 2019;  doi: 10.21926/obm.transplant.1901046

Abstract

In the U.S., older adults aged 65 or above comprise nearly one quarter of the solid organ transplant (SOT) waitlists, and the number of transplants performed in this age group continues to increase. There are no specific guidelines for the assessment and follow up of the aged SOT candidate or recipi [...]
Open Access Case Report

Isolated Hepatic Mucormycosis in the Early Post-Transplant Period: A Case Report and Literature Review

Received: 08 October 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901045

Abstract

Mucormycosis is a rare fungal infection associated with high morbidity and mortality that typically afflicts immunocompromised hosts. We present a case of isolated hepatic mucormycosis that developed in the early post-transplant period. Initial presentation was concerning for allograft rejection, bu [...]
Open Access Review

Parvovirus B19 Infection in Solid Organ Transplantation: Report of A Case and A Review

Received: 05 November 2018;  Published: 20 January 2019;  doi: 10.21926/obm.transplant.1901040

Abstract

Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection. Clinical disease can occur due to acute infection, secondary infection, or reactivation. The clinical presentation of primary infection depends on age, the presence of a hematologic [...]
Open Access Review

Chagas Disease, Leishmaniasis, and Malaria in Solid Organ Transplant Recipients

Received: 28 October 2018;  Published: 15 January 2019;  doi: 10.21926/obm.transplant.1901039

Abstract

Solid organ transplantation (SOT) is increasingly employed worldwide to treat several diseases causing either acute and chronic organ failure. Recipients of SOT are at increased risk to develop infections as a consequence of immunosuppressive therapy. Sometimes such infections may be acquired by the [...]
Open Access Review

A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation

Received: 02 November 2018;  Published: 08 January 2019;  doi: 10.21926/obm.transplant.1901038

Abstract

Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus that has become endemic in the US since its arriv [...]
Open Access Review

An Approach to Fungal Diagnostics in Solid Organ Transplantation

Received: 14 November 2018;  Published: 29 December 2018;  doi: 10.21926/obm.transplant.1804037

Abstract

The approach to diagnosing fungal infections following solid organ transplantation (SOT) is patient-specific. An assessment of an individual’s risk for particular infections, also understood as the pre-test probability, should guide appropriate diagnostic testing whereas diagnostic stewardship is ne [...]
Open Access Review

Strongyloidiasis in Solid Organ Transplantation

Received: 31 October 2018;  Published: 27 December 2018;  doi: 10.21926/obm.transplant.1804035

Abstract

Strongyloides stercoralis, an intestinal parasitic nematode (roundworm), infects more than 100 million people worldwide. While most infected immunocompetent persons are either asymptomatic or experience only mild, intermittent symptoms, immunosuppressed individuals, including those undergoing solid [...]
Open Access Research Article

The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunction

Received: 11 September 2018;  Published: 30 November 2018;  doi: 10.21926/obm.transplant.1804029

Abstract

The long term clinical significance of respiratory infections after lung transplantation remains uncertain. In this retrospective single-center cohort study of 441 lung transplant recipients, we formally evaluate the association between respiratory infection and chronic lung allograft dysfunction (C [...]
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